Isn't this just more confirmation of Wakefield et al's original hypothesis?

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Posted on PediatricSuperSite.com January 24, 2012

Bacterial gut samples differed between autistic and non-autistic

children

BL. mBio.

2012;doi:10.1128/mBio.00261-11.

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Communities of microorganisms that reside in the gut of

autistic children with gastrointestinal problems are different than communities

residing in non-autistic children, according to study results published in the

online journal mBio.

Following up on a previous study, which identified that

Alcaligenaceae bacterium sequences in ileal and cecal biopsy samples

from

autistic children with gastrointestinal dysfunction were

completely absent from biopsy samples of non-autistic children with

gastrointestinal dysfunction, Brent , PhD, and colleagues of the

Mailman School of Public Health at Columbia University subjected samples to

real-time polymerase chain reaction (PCR) analysis.

Researchers analyzed 23 biopsy samples from autistic

children with nine biopsy samples from non-autistic children and observed that

increased levels of Alcaligenaceae in autistic children resulted from

the incidence of elevated levels of members of the genus Sutterella.

Utilizing a Sutterella-specific PCR assay for detecting, quantitating

and genotyping Sutterella species in the samples, the study found

Sutterella 16S ribosomal RNA (rRNA) gene sequences in 12 of 23 autistic

children, yet none in the nine non-autistic children.

Further phylogenetic analysis identified a high

proportion of either S. wadsworthensis or S. stercoricanis in 11

of the Sutterella-positive autistic patients, whereas the remaining

patient could not be given a species-level classification based on the 16S rRNA

gene sequences of known Sutterella isolates.

“The nature of

intestinal damage in autism has not been fully defined,”

the researchers said. “A defective epithelial barrier could lead to

enhanced contact between many members of the microbiota and antigen-presenting

cells in the lamina propria. If this turns out to be the case in autism, then

antibodies against Sutterella proteins may reflect interindividual,

compositional variation in the microbiota, rather than being an indication of

Sutterella infection. Additional studies are warranted in order to draw

definitive conclusions from this immunological analysis.”

Disclosure: The researchers report no relevant

financial disclosures.

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Cover Story

Spike in foodborne outbreaks highlights need for

improvements

Approximately one in six people are infected with a foodborne illness

each year in the United States, according to the CDC. The costs of foodborne

illness are vast; Salmonella alone has accounted for $365 million in

direct medical costs. Recent outbreaks this year have highlighted the need for

improvements in the system — outbreak reporting and diagnosing illness in

patients must improve. However, in some instances, positive outcomes have been

demonstrated. The quick response time in the Listeria outbreak led to

the swift identification of the food vector, which was promptly removed from

the market.

Full Story

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