FW: Herpes vaccine fails

[Guest guest]

Excellent news! Written on January 5, 2012 by BHRHerpes Vaccine Fails to Protect WomenFiled under Disease, Health, Medicine, VaccinationsComments (1)3A once-promising vaccine against herpes viruses has failed in a large clinical trial, researchers reported.The vaccine had markedly reduced the risk of genital herpes disease in women in so-called serodiscordant couples, in which one partner had the virus and other did not, according to Dr. Belshe of St. Louis University in St. Louis, Mo., and colleagues.But in a large study intended to mimic the general population of uninfected women, vaccine efficacy against disease was only 20 percent, the researchers reported in the Jan. 5 issue of the New England Journal of Medicine.“We’re really disappointed by the results,” study co-author Dr. Leone of the University of North Carolina in Chapel Hill told MedPage Today. But, he said, “it’s the reason we do clinical trials.”

[Guest guest]

Oh dear, ANOTHER FAILED vaccine!

From:

Venita Garner <nitagarner@...>;

To:

<Vaccinations >;

Subject:

FW: Herpes vaccine fails

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Fri, Jan 6, 2012 7:10:01 PM

Excellent news! Written on January 5, 2012 by BHRHerpes Vaccine Fails to Protect WomenFiled under

Disease, Health, Medicine, VaccinationsComments (1)3A once-promising vaccine against herpes viruses has failed in a large clinical trial, researchers reported.The vaccine had markedly reduced the risk of genital herpes disease in women in so-called serodiscordant couples, in which one partner had the virus and other did not, according to Dr. Belshe of St. Louis University in St. Louis, Mo., and colleagues.But in a large study intended to mimic the general population of uninfected women, vaccine efficacy against disease was only 20 percent, the

researchers reported in the Jan. 5 issue of the New England Journal of Medicine.“We’re really disappointed by the results,” study co-author Dr. Leone of the University of North Carolina in Chapel Hill told MedPage Today. But, he said, “it’s the reason we do clinical trials.”

[Guest guest]

Interesting. Efficacy was not measured by antibodies: "The primary endpoint was occurrence of genital herpes disease due to either HSV-1 or HSV-2."

I'm shocked. Actually measuring results in cases!

Even more interesting: "It was 58 percent efficacious against disease caused by HSV-1 but had no effect against HSV-2 disease" which" is regarded as more worrisome since it tends to recur more than HSV-1 and also is associated with an increased risk of acquiring HIV."

Researchers are puzzled because two previous studies on HSV-2 showed efficacy. I wonder how those was measured.

Winnie

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