More on this & testing................Many unable to detoxify drugs due to lack of enzyme pathway

[Guest guest]

more for you all

man oh man.............

http://vaccineliberationarmy.com/pharmagedon-what-is-2d6-making-our-kids-psychotic/

" Pharma sins in modern psyche history. The

information that would have averted the school shootings, the homicides,

the overdoses, the bizarre epidemic of mentally ill in recent years has

been available for circa 15 years since gene mapping.

Cytochrome P450 2D6 is the most major metabolic pathway that detoxifies

50% of all psyche drugs and street drugs. 7-10% of Caucasians, for

example, are poor or non-metabolizers due to a deletion or

non activity of the 2D6 pathway "

" When certain drugs (list below) are given to these

demographics, due to their inability to metabolize them, these

people become psychotic, homicidal, suicidal, a danger to themselves and

society. "

" These drugs force the patient who is a poor or non-metabolizer into

heinous acts against themselves and society. And who and what is

really complicit when a crime is committed? The manufacturer who

“failed to warn”?; the physician who “failed to warn” and who did not do

the simple genetic test "

MORE info at the webpage including:

This comment from a reader sounds like something I have

been through with a loved one (not jail but much similar):

Jan says:

September 5, 2011 at 6:18 am

My husband is currently on remand for breach of a DVO and possession of

weapons. He has been on various forms of opiates over the last 3 years

for a genuine medical reason. Since the moment he started taking them his

behaviour changed, he became cognitively impaired, his reasoning and

logic just went out the door, it was like the consequential thinking

switch in his brain turned off. He became aggressive, paranoid,

delusional however that was just the opiates, which the main one was

Oxycontin.

Every now and then the doctors would also put him on Benzo’s, either

serapax or xanax, then he would have what we now know is a paradoxical

reaction on top of the already changed behaviour from the Oxy. I tried

going to see his GP’s by myself o explain my concerns about what the

medication was doing but no one listen to me and just had an open script

for him,

He also went just 6 weeks prior to the incident that landed him in jail

to QLD Mental health, he was in a lucid state and was able to comprehend

and asked for an intervention plan to keep me and the kids safe…they sent

a letter telling him to go to a pain psychologist, this is despite him

telling them he was suicidal in these episodes and had the ability to

harm me and the kids, and I informed them of his hallucinations and

bizarre behaviour, they were also informed he was seeing a pain

psychiatrist. He told his GP to never prescribe him oxy again, so the Gp

there and then wrote a script for him for 100 2mg Xanax with 2

repeats……He lost it, went to see his cousin who just happens to be in a

bike gang, got hold of a gun but no bullets, also got hold of some Meth,

was trying to source bullets so he could kill himself, when he had the

hallucination that i was going to kill him so he tried to choke me to

death….and he is now in prison and a family is destroyed as no one

listened to the patient or his family. The funny thing is, he has been in

there for 6 weeks and his pain has improved dramatically as the oxycontin

was in fact increasing his pain not decreasing it and no one listened to

the symptoms he was presenting….

Genetic testing should be mandatory before long term use….

Here is the study:

http://www.dovepress.com/articles.php?article_id=7993

" Conclusion: The personal, medical, and legal problems

arising from overuse of antidepressant medications and resulting toxicity

raise the question: how can such toxicity events be understood and

prevented? The authors suggest that the key lies in understanding the

interplay between the subject’s CYP450 genotype, substrate drugs and

doses, co-prescribed inhibitors and inducers and the age of the subject.

The results presented here concerning a sample of persons given

antidepressants for psychosocial distress demonstrate the extent to which

the psychopharmacology industry has expanded its influence beyond its

ability to cure. The roles of both regulatory agencies and drug safety

“pharmacovigilantes” in ensuring quality and transparency of industry

information is highlighted. "

http://vaccineliberationarmy.com/wp-content/uploads/2011/10/Mayo-cyp-2.pdf

Mayo Clinic report

" Currently‚ much of the pharmacogenetic effort is focused on

defining those genotypes that can explain why some patients do not

respond to high doses of a medication‚ while others have side effects or

toxic reactions at low doses of the same medication. Since cytochrome

(CYP450) enzymes are responsible for metabolizing nearly half of all

drugs on the market today‚ much effort has been directed at cataloging

the P450 gene variants (polymorphisms) that cause individual variability

in drug response.2,3 "

" Most psychotropic medications, including all common selective

serotonin reuptake inhibitors (SSRIs), all common tricyclic

antidepressants (TCAs)‚ and some benzodiazepines and antipsychotics‚ are

metabolized by the CYP450 enzymes. Mayo Medical Laboratories offers 3

CYP450 tests: "

" Mayo Medical Laboratories currently offers testing for CYP2D6,

CYP2C9‚ and CYP2C19. Test results are provided in an interpretive report

that includes assay information‚ genotype‚ and an interpretation

indicating whether results are consistent with a PM‚ IM‚ EM‚ or UM

phenotype. The report lists drugs known to affect metabolism by the

CYP450 enzyme of interest. The reports are prepared by a group of

clinical and laboratory specialists who provide expert consultative

support "

SHOULD TEST FOR:

It is really easy. Just get 6 sterile swabs from the pharmacy or a

doctor's office.

Swab inner cheeks and gums really well to get a lot of " gunk "

on the swabs.

You will ask for:

CYP2D6

CYP2C19

CYP2C9

VKORC1

Info on a company that tests:

http://www.cap.org/apps/cap.portal?_nfpb=true & cntvwrPtlt_actionOverride=%2Fportlets%2FcontentViewer%2Fshow & _windowLabel=cntvwrPtlt & cntvwrPtlt{actionForm.contentReference}=cap_today%2Ffeature_stories%2F0706pharma.html & _state=maximized & _pageLabel=cntvwr

http://www.isdbweb.org/documents/file/4de3b492d689f.pdf

http://www.healthanddna.com/drug-safety-dna-testing/depression.html

Depression meds

http://www.healthanddna.com/drug-safety-dna-testing/pain.html Pain

meds

http://www.nwabr.org/education/pdfs/Pharmacogenetics/TPMT_LESSON.pdf

CYP2D6, CYP2C9, CYP2C19, and CYP1A2

testing is currently offered by the Seattle-based Genelex company

(2).

In the USA it ranges from $650 to $3,800 - The same test in

Australia will be $270.00.

http://www.lucire.com.au/documents/Cytochromes-paradigmatic.aspx

someone I am in communication with - Dr. Yolanda Lucire

How to talk to your doctor:

http://www.healthanddna.com/drug-safety-dna-testing/Talk-to-your-doctor.html

http://www.healthanddna.com/drtdrletterfrompatient.pdf

Testing for CYP2D6, CYP2C9 (with VKORC1 for warfarin), and CYP2C19

can be billed through insurance. Testing

of CYP1A2, 5HTT, DPD, UGT1A1, and NAT2 can be billed to the patient or

your practice.

http://www.healthanddna.com/drug-safety-dna-testing/faq-dna-drug-sensitivity-testing.html

How are drugs processed by the body?Drugs act on

target sites in body tissues to cause a therapeutic effect. They are

removed from the body by being converted into an inactive form. The P-450

family of drug metabolizing enzymes inactivates most prescription drugs.

The most important and most thoroughly studied of these enzymes are

CYP2D6 and CYP2C9. More than half of the population has at least one

defect in these enzymes that can greatly increase the risk of an adverse

drug reaction.

What genes are most useful to test?

CYP2D6 (cytochrome P450 2D6) is the best studied of the DMEs

(drug metabolizing enzymes) and acts on one quarter of all prescription

drugs. Approximately ten percent of the population have a slow acting

form of this enzyme and five percent a super-fast acting form. Drugs that

CYP2D6 are thought to inactivate include Prozac, Zoloft, Paxil,

Effexor,hydrocodone , amitriptyline, Claritin, cyclobenzaprine, Haldol,

metoprolol, Rythmol, Tagamet, tamoxifen, and the over-the-counter

diphenylhydramine drugs, Allegra, Dytuss and Tusstat. CYP2C9 (cytochrome P450 2C9) is the primary route of

metabolism for Coumadin (warfarin), Amaryl, isoniazid, sulfa and

ibuprofen. Clinical studies suggest that the use of genetic testing may

be especially helpful with warfarin administration. Other drugs that are

thought to be metabolized by 2C9 include, amitriptyline, Dilantin,

Hyzaar, THC (tetrahydrocannabinol), naproxen and Viagra. CYP2C19 (cytochrome P450 2C19) is associated with the

metabolism of carisoprodol, diazepam, Dilantin, and Prevacid. CYP1A2 (cytochrome P450 1A2) is associated with the metabolism

of amitriptyline, olanzapine, haloperidol, duloxetine, propranolol,

theophylline, caffeine, diazepam, chlordiazepoxide, Premarin, estrogens,

tamoxifen, and cyclobenzaprine. NAT2 (N-acetyltransferase 2) is a second step drug

metabolizing enzyme that acts on isoniazid, and procainamide and

Azulfidine. The frequency of the NAT2 " slow acetylator " in

various worldwide populations ranges from 10% to more than 90%.