Improved early muscle reinnervation using FK506

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Abstract from J Reconstr Microsurg. 2004 Mar;20(2):183-92. Links

Improved early muscle recovery using FK506 in a rat nerve-repair model.

Aydin MA, Urbanchek MG, Kuzon WM.

Department of Plastic Surgery, Suleyman Demirel University, Isparta,

Turkey.

The authors hypothesized that FK506 improves maximal muscle force (P

(0)) recovery during early muscle reinnervation. Rat peroneal nerve was

unilaterally cut and repaired. Rats received subcutaneous injections of

vehicle (controls) or FK506 at 1 mg/kg (FK506-1MG) or 5 mg/kg

(FK506-5MG) for 3 weeks. Extensor digitorum longus (EDL) isometric

muscle P (0) was measured bilaterally 4 weeks postoperatively. FK506

treatment adversely affected body mass. With body mass as a covariate,

the P (0) for denervated-reinnervated muscle in the FK506-5MG group was

statistically significantly higher by 34 percent and 32 percent,

compared with controls and FK506-1MG groups. There was no group

difference for the contralateral, nerve-intact EDL muscle P (0), when

loss of body mass was considered. NCAM immunohistologic data showed

significantly better reinnervation of the denervated muscle in a

dose-dependent fashion. Thus, FK506 treatment at high dose improves

early recovery of force in denervated-reinnervated muscle, following

nerve repair, when loss of body mass is considered.