Guest guest Posted January 29, 2004 Report Share Posted January 29, 2004 Stan, This is about Sonic Hedgehog Protein - it what was in one of the issues in 2003 of CMT...Today magazine. Just a bit of a change since - Curis has a new partnership with Wyeth. Elan is out of the picture. ****************************** Sonic Hedgehog Protein - by Gretchen Glick Copyright 04/02/03 Within each nerve, there is a signaling pathway called hedgehog. (this has nothing to do with the hedgehog animal!) When the hedgehog pathway is insufficient, nerve regeneration is slowed or absent. The hedgehog pathway also regulates tissue and organ formation throughout human development and adulthood. The signaling pathway of Hedgehog (Hh) that occurs during development is often the same pathway the body calls on in adulthood to maintain physiological balance and to repair and regenerate nerves. Curis is a therapeutic drug development company with a technological discovery on regulating the hedgehog pathway that controls and repairs nerve regeneration. One Curis product involves using proteins or small molecules to modulate this pathway. This is sonic hedgehog protein. The Hedgehog (Hh) pathway is essential for the formation of normal nerves in the peripheral nervous system, as well as in the central nervous system. Curis scientists have shown that treatment with sonic hedgehog protein accelerates nerve recovery in animal models of nerve trauma and disease. This protein has also proved successful in human trials of diabetic neuropathy. Curis scientists have developed a series of small molecule Hh compounds that mimic the activity of the protein. These compounds could be taken in pill form. Some of these small molecule Hh compounds are more potent than the original Hh protein. These compounds are being evaluated further before human trials begin for peripheral neuropathies, including HMSN/CMT. Hedgehog protein research is now being conducted under a joint venture between Curis and Elan Corporation established in 2001. See www. Curis.com and www.Elan.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2004 Report Share Posted January 29, 2004 Gretchen, Thanks for the updates. Now that I have brought up " dates " when do they think NT-3 and or Sonic will be available?? Quote Link to comment Share on other sites More sharing options...
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