New CMT 1A Research from Italy

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From Eur Neurol. 2004 Apr 1;51(3):168-171.

Brain White Matter Lesions in an Italian Family with Charcot-Marie-Tooth

Disease.

Sacco S, Totaro R, Bastianello S, Marini C, Carolei A.

Department of Neurology, University of L'Aquila, L'Aquila, Italy.

Type 1A, the most common form of Charcot-Marie-Tooth (CMT1A) disease, is

characterized by demyelination of the peripheral nervous system. So far,

only a few cases of the disease with concomitant brain white matter

lesions have been described. We report an Italian family with CMT1A

disease, consisting of the proband and 4 affected members, presenting

with concomitant brain white matter lesions at magnetic resonance

imaging. The association is particularly fascinating and might depend on

an autoimmune mechanism, not yet clarified.