Trazodone interaction with certain medications

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Health Canada warning on Trazodone interaction with certain medications

Friday, 9-Jul-2004 News-Medical.Net

Health Canada, in association with Bristol-Myers Squibb Canada, is

advising Canadians to consult with their health care professionals if

they are currently being treated with the antidepressant trazodone in

combination with any of the following medications: ketoconazole (an

antifungal agent), ritonavir and indinavir (protease inhibitors used in

the treatment of HIV), or carbamazepine (an anti-epileptic therapy).

When trazodone is combined with these drugs, patients may experience the

following symptoms: nausea, low blood pressure, temporary loss of

consciousness (increased trazodone levels), or decreased effectiveness

of the trazodone therapy (decreased trazodone levels).

Patients who have questions about their current medications, should

consult with their physician or pharmacist directly. It is important

that patients do not stop taking medications without first consulting

with a health care professional.

This advisory applies to the following antidepressants:

Apo-Trazodone (Apotex incorporated)

Desyrel (trazodone) (Bristol-Myers Squibb)

Dom-Trazodone (Dominion Pharmacal)

Gen-Trazodone (Genpharm Inc.)

Trazorel (ICN Canada Ltd.)

Novo-Trazodone (Novopharm Limited)

Nu-Trazodone (Nu-Pharm Inc.)

Penta-Trazodone (Pentapharm Ltd.)

PMS-Trazodone (Pharmascience Inc.)

PHL-Trazodone (Pharmel Inc.)

Trazodone (Pro Doc Limitée)

Ratio-Trazodone (Ratiopharm Inc.)

Scheinpharm Trazodone (Schein Pharmaceutical Canada Inc.)

Bristol-Myers Squibb Canada, in collaboration with Health Canada, has

sent a letter to health care professionals to inform them of this safety

information. A copy of the letter can be found at Health Canada's

website at:

http://www.hc-sc.gc.ca/hpfb-dgpsa/tpd-dpt/index_advisories_professionals_e.html

Health Canada is also working with manufacturers to revise the

prescribing information found in the Product Monograph for trazodone in

order to provide physicians and pharmacists with updated safety

information regarding drug interactions.

http://www.hc-sc.gc.ca