new online + searchable European register of clinical trials in children

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A new online and searchable European register of clinical trials in

children

Posted By: News-Medical in Child Health News News-Medical.Net

19-Jul-2004

A new online and searchable European register of clinical trials in

children, which has been developed in collaboration with academics at

The University of Nottingham and will make the practice of paediatric

medicine safer and more effective, has recently been launched.

The register is a landmark in the field of clinical research because it

will be the first clinical trials database dedicated to the paediatric

population. Developed by four European child health centres — Derby,

Milan, Paris and Barcelona — it will address the well-documented lack of

scientific knowledge on the use of medicines in children.

The British arm of the register has been developed by the University’s

Academic Division of Child Health, based at Derbyshire Children’s

Hospital. It is being developed and managed by Professor Imti Choonara,

Dr Helen Sammons and Dr Steingo.

Dr Steingo said: " Several factors have been blamed for the lack of

research being performed in sick children — including a lack of

financial incentive and practical difficulties in performing trials —

but the common outcome is that health professionals treating children

are often forced into using medicines that are only licensed for use in

adults. This means that the drugs used to treat children are often not

used to their full potential and may even be potentially toxic to them. "

For several years now, Dr Steingo added, clinicians have spoken about

the creation of clinical trial ‘registers’ to keep track of ongoing and

planned trials. The intention of a register is to promote transparency

within the realm of clinical research and to provide access to current

information for anyone interested, including health professionals and

the public.

From a professional’s perspective, a register helps to prevent

duplication and under-reporting of trials and publication bias. It also

helps to promote coordination of research, identification of patients’

therapeutic needs, collation of knowledge, and guidance in allocation of

funds. From a patient’s point of view, it can help to identify trials

relevant to that patient’s condition, allowing them to enrol onto trials

that study the most up-to-date medicines.

Several medical research registers have been developed over the past

decade. However, they have all failed to address the paediatric

population adequately and have not succeeded in stimulating the

much-needed research on medicines for children.

The new register is international, web-based, will allow free access to

all and contain a set of core information for each trial entry,

including such fields as title of trial, research question and contact

details for the lead researcher. It will be updated every six months and

be searchable to professionals and the public. Parents will therefore be

able to identify trials in their region in which their children might be

eligible for participation.

The project has been backed by the Royal College of Paediatrics and

Child Health, the body responsible for training paediatricians and

setting standards of child health practice in the UK, and the Neonatal

and Paediatric Pharmacists Group, a network of British paediatric

pharmacists.

The new database can be accessed on the web at www.dec-net.org

http://www.nottingham.ac.uk/