CMT Disease (Hereditary Motor Sensory Neuropathies) and Hereditary Sensory & Autonomic Neuropathies

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Abstract from Neurologist. 2004 Nov;10(6):327-337.

Charcot-Marie-Tooth Disease (Hereditary Motor Sensory Neuropathies) and

Hereditary Sensory and Autonomic Neuropathies.

Bertorini T, Narayanaswami P, Rashed H.

From the Department of Neurology, College of Medicine, University of

Tennessee, Memphis, Tennessee.

Since the description of Charcot-Marie-Tooth disease over a century ago,

it is now been recognized that these conditions are not caused by

generalized metabolic defects but rather have various discrete genetic

origins. These disorders can also have variable phenotypes due to

dysfunction of peripheral nerve axons or their myelin due to the genetic

defects that affect the formation of specific nerve proteins.