Suffocation of Nerve Fibers by Living Nanovesicles: A Model Simulation-Part II

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Abstract from J Proteome Res. 2004 Oct 11;3(5):1086-1088.

(Mentions peripheral neuropathy)

Suffocation of Nerve Fibers by Living Nanovesicles: A Model

Simulation-Part II.

Sommer AP.

Central Institute of Biomedical Engineering, University of Ulm, 89081

Ulm, Germany.

Nanobacteria may cause peripheral neuropathy by adhesion to the

perineurium. This hypothesis receives support from five independent

observations: (1) identification of perineurial apatite in diabetic

patients with peripheral neuropathy, (2) massive presence of

nanobacteria in a diabetic patient, (3) beneficial effect of lasers on

peripheral neuropathy, (4) model simulation indicating that perineurial

deposition and attachment of nanobacteria is encouraged by both their

size and chemical nature, and (5) transient inhibition of neural

function by apatite. Initial deposition of (stressed) nanobacteria is

promoted by a slime thought to consist of proteins, calcium, and

phosphate, and is most likely followed by an immobilization phase,

mediated by a bioadhesive capacity of the apatite. Proteomics may hold

the key to control both attachment processes.