Vitamin C regulates the expression of some genes participating in apoptosis or DNA repair processes

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Abstract from Postepy Hig Med Dosw (Online). 2004 Sep 20;58:343-8.

[Role of vitamin C in oxidative DNA damage]

Konopacka M.

Vitamin C (ascorbic acid) has considerable antioxidant activity: it

scavenges reactive oxygen species and may, thereby, prevent oxidative

damage to important biological macromolecules, such as DNA, proteins,

and lipids. Data concerning the influence of vitamin C on oxidative DNA

damage are conflicting and some of the discrepancies can be explained by

the different experimental methodologies employed. Data using biomarkers

of oxidative damage of DNA bases in human lymphocytes in vitro have

provided no compelling evidence to conclude that vitamin C

supplementation can decrease the level of oxidative DNA damage. There

are also no conclusive data from studies of strand breaks for a

protective effect of ascorbic acid. The consumption of food rich in

vitamin C (fruits and vegetables) appears more protective because it

exerts more positive effects in decreasing oxidative DNA damage to human

cells. Recent studies indicate that vitamin C is much more than just an

antioxidant; it regulates the expression of some genes participating in

apoptosis or DNA repair processes. The purpose of this review is to

provide a summary of the role of vitamin C in oxidative DNA damage.