Guest guest Posted August 11, 2004 Report Share Posted August 11, 2004 Research Abstract from Mov Disord. 2004 Aug;19(8):978-81. Does parkin play a role in the peripheral nervous system? A family report. Abbruzzese G, Pigullo S, Schenone A, Bellone E, Marchese R, Di E, Benedetti L, Ciotti P, Nobbio L, Bonifati V, Ajmar F, Mandich P. Department of Neuroscience, Ophthalmology and Genetics, Section of Neurology, University of Genova, Italy. Two genes were identified for autosomal recessive forms of early onset Parkinson's disease: parkin and DJ-1. We describe 2 siblings with EOPD due to parkin mutations and peripheral neuropathy, which presented as neuropathy with liability to pressure palsies (HNPP) in the index case. RT-PCR experiments revealed that the parkin gene is expressed in sural nerves from both controls and patient with parkin-related disease. Our findings support the view that parkin may play a role in the peripheral nervous system. Quote Link to comment Share on other sites More sharing options...
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