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Study looks at muscle repair and resilience

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Study looks at muscle repair and resilience

http://www.news-medical.net/?id=6737 7-Dec-2004

Healthy military personnel and muscular dystrophy patients are at opposite ends

of the spectrum when is comes to muscle strength and resilience. However, a new

University of Iowa study may provide insights that improve muscle health for

both these groups.

Researchers in the UI Roy J. and Lucille A. Carver College of Medicine have been

awarded a four-year, $1.97 million grant from the United States Department of

Defense to study how muscles resist damage and repair damage that does occur.

Improved understanding of the mechanisms involved in muscle resilience and

repair could lead to strategies for enhancing muscle recovery following

strenuous exercise, or treating muscle deterioration caused by diseases like

muscular dystrophy.

The study, led by , Ph.D., the Roy J. Carver Chair of Physiology

and Biophysics and interim head of the department, professor of neurology, and a

Medical Institute (HHMI) Investigator, will build on earlier

muscular dystrophy studies from 's lab that identified important roles

for two proteins in muscle maintenance and repair. , M.D., Ph.D., UI

professor of pathology, is co-principal investigator on the grant.

The UI team previously discovered that the action of a sugar-adding protein

called LARGE prevents muscle deterioration caused by muscular dystrophy by

restoring the function of a critical muscle protein. 's lab also

discovered that a protein called dysferlin is required for muscle repair.

The team will use the grant to conduct a series of experiments to investigate

how dysferlin and LARGE function in muscle cells, and to learn if increased

expression of either protein leads to enhanced muscle membrane strength or

improved reparative capabilities in normal or dystrophic muscle.

http://www.uiowa.edu

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