inheritance/incidence rate observation

[Guest guest]

I have 13 friends with CMT representing 13 families, that I keep in regular

touch with.

Out of these 13 friends, there are 28 offspring with CMT.

8 offspring in these families have CMT 1A.

4 offspring in these families have CMT Type 2.

3 offspring have CMT Type X.

4 offspring in these families have a CMT spontaneous mutation with no family

history.

The remaining offspring have not been tested to determine a type.

What I have observed over the years is that the incidence rate of CMT is quite

different than the 'proposed' 50/50 inheritance rate. Also, symptoms and onset

age of CMT can be very different - even within the same family.

Gretchen

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