autosomal dominant/recessive/x

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Autosomal dominant:

People with CMT from this inherited pattern have one normal gene and one

defective gene on the affected chromosome. This applies to both men and women

and each child of a parent with an affected gene has a 50% chance of being

affected. Children who are affected as a result will in turn have a 50% chance

of passing the defective gene on to their children. Conversely, unaffected

children do not carry the defected gene thus cannot pass on the disease to their

children. Autosomal dominant is the most common pattern of inheritance and

affects CMT type 1A, 1B, 1C, and all variants of type 2.

Autosomal recessive:

People who have CMT as a result of an autosomal recessive inherited pattern

indicate that both of their parents carried the defective gene, even if the

parents themselves did not have any apparent symptoms. In this patterning each

of their children has a 25% chance of inheriting a double dose of the defective

gene. An affected child can pass on the disease only if he/she is partnered with

someone who also is a carrier, thereby their children have a 50% chance of

having the defective gene. Unaffected children of parents with an autosomal

recessive predisposition will not carry the gene. However, a carrier child who

is not affected directly has a 50% chance of having a carrier child. Autosomal

recessive is primarily associated with type

4.

X-linked:

People who acquire CMT through an X-linked inherited pattern do so through the X

chromosome which determines the sex of the child. In this case primarily

mother’s who are carrier, and who may or maybe be affected themselves, have a

50% chance of passing the defective gene to their sons. In which chase they will

likely be affected more severely. Daughters in this case have a 50% chance of

being a carrier of the defective gene. Unaffected children cannot pass on the

disease. Should the father be an affected carrier all his daughters will be

carriers but will not affect any of his sons

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