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CMT or something else?

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Hi, my name is . About 10 years ago, my father was diagnosed with CMT, but

I don't believe it was through a blood test. He has the pain and numbness in

his feet and legs, the hammertoe (which he had operated on), high arch (when he

had flat feet his whole life), drop foot, muscle atrophy, poor balance, hand

tremors, etc.

About 3 years ago, my 2 sons were diagnosed with Fragile X Syndrome, the leading

cause of inherited mental impairment. Shortly after receiving this diagnosis,

researchers discovered that about 20% of the grandfather male carriers of

Fragile X were suffering from symptoms similar to CMT - tremors, neuropathy,

poor balance, cognitive loss, etc., all of which get worse over time, with most

eventually losing the ability to walk. The condition is called

FXTAS.

A few months ago, our family participated in a research program for Fragile X

and FXTAS. The doctors there were very interested in my father's case because

he has so many more symptoms than their other participants. They think that he

may have both FXTAS and CMT. They are both X-linked disorders, and apparently

very closely related.

I have been reading your posts, and I have seen some characteristics that I have

noticed in myself - Pain in my feet upon rising from bed that goea away after

walking around for a little while, difficulty swallowing (at times), difficulty

breathing when lying down (which I always attributed to my sinuses), occasional

tremors in my hands, fatigue after exercising.

I have always marveled when I hear that exercise is supposed to give you more

energy. I struggle to stay awake for the rest of the day after I exercise. I

don't have terrible balance, but I have never been able to walk in a straight

line. When I walk with others, I usually walk into them. I have had pains in

my legs that I have compared to migraines my whole life, but advil and heat cure

them.

I welcome your feedback. I am also interested to hear if any of you have any

developmental disabilities in your families - including learning disabilities or

more severe impairments, speech, fine and gross motor delays, autistic behaviors

such as hand flapping, hand biting, perseveration, OCD, ADHD, difficulties with

transitions and unexpected changes.

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