Guest guest Posted February 8, 2005 Report Share Posted February 8, 2005 I don't know if this applies to CMT, but as far as I know, with genetics in general, if the female is affected, there is a 50/50 chance of passing it on with each pregnancy. She has 2 X chromosomes, and only one would get passed on to each offspring. I know that CMT is an X-linked disorder, so it can only be passed through the X. An affected male would only pass it on to his daughters via the X, but not his sons because of the Y. I know of other X-linked disorders where the mother passes it on, but the unaffected X chromosome can take over, and no signs of the disorder are apparent. Perhaps this could account for the parents who show no signs, but the children do. **** , not all CMT is X-linked. CMT Type 1 and CMT Type 2 and their respective subtypes are NOT X-linked. Obviously X-linked CMT IS. Females with X linked CMT CAN sometimes not show symptoms (meaning they are asytomatic). On the other hand, I know CMT X females who show very serious symptoms. ~ Gretchen Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.