Guest guest Posted December 17, 2004 Report Share Posted December 17, 2004 Abstract from Rev Neurol (Paris). 2004 Dec;160(12):1203-6. Hereditary neuropathy with liability to pressure palsy presenting with an acute inflammatory demyelinating polyneuropathy. Degos B, Echaniz-Laguna A, Latour P, Vandenberghe A, Anheim M, Talmant V, Tranchant C. Departement de Neurologie, Hopital Civil de Strasbourg, Strasbourg, France. Introduction:Hereditary neuropathy with liability to pressure palsy (HNPP) is an autosomal dominant peripheral neuropathy characterized by compressive focal neuropathies and an underlying sensorimotor demyelinative polyneuropathy. It is usually caused by a 1.5 Mb deletion of the PMP22 gene (17p11.2). Case Report: We describe the case of a 31 years-old woman who presented with acute demyelinative peripheral polyneuropathy affecting the four limbs and elevated cerebrospinal fluid protein content a few days after a viral illness. Acute inflammatory demyelinating polyneuropathy (AIDP, Guillain-Barre syndrome) was suspected. However, electrophysiologic examination suggested HNPP and subsequent genetic testing was confirmatory. CONCLUSION: This case demonstrates that HNPP can present in an acute manner, mimicking AIDP. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 17, 2004 Report Share Posted December 17, 2004 http://www.reeve.uci.edu/index.html Gretchen - Thanks a bunch for posting the HNPP information. Seems there's a lot of " mimicking " of CMT/HNPP going around these days. Check out the link I've provided above. It's about the most current stem cell research being done by a doctor at the REEVE-IRVINE research lab. It's quite interesting and gives more hope than I've seen from the scientific medical community in a very long time. Dr. Hans Keirstead seems to have been able to cause mice and rats to walk again after trauma to their spine using a " stem cell cocktail " (my words) he has developed. The article goes on to talk about human trials in 2006. I believe it is he that is quoted when said, " I want to make sure toe nails don't grow in the brain first before testing on humans. " And, that would be a good idea!!!! Again, the link is above. Just search through the main page - it's right there - and you'll find the entire article. I did see a 2003 date on the institute's description page, however, the article you'll find about Dr. Keirstead's research was posted just today on my Comcast.net IP. rQn I Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 18, 2004 Report Share Posted December 18, 2004 RQN, Very interesting info at Irvine, thanks. I was particularly interested in the reinnervation and regeneration. Also Joan 's quote to Chris. Yes, it seems too many disorders are looking like " mimics " - seems to create brand new territory. Gretchen Quote Link to comment Share on other sites More sharing options...
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