Dynamin 2 - Gene Defect Linked to Familial Nerve Disorder

[Guest guest]

(This discovery may shed some light on some types of CMT type 2 and may play a

role in developing more DNA testing for Type 2s ~ Gretchen)

Gene Defect Linked to Familial Nerve Disorder

MONDAY, Jan. 31 (HealthDayNews) -- A defect in a gene called dynamin 2 causes

one form of the inherited nerve disorder Charcot-Marie-Tooth (CMT) disease,

according to a new study.

Researchers at Duke University's Center for Human Genetics, say they have also

identified a previously unknown association between CMT and a deficiency of

white blood cells. This suggests defects in dynamin 2 may be linked to both

conditions.

Dynamin 2 fulfills a number of functions in cells throughout the body, but this

is

the first time it has been implicated in human disease. The study appears in the

Jan. 30 issue of Nature Genetics.

The finding, along with earlier research, provides scientists with new

information

about the nervous system and may offer a better understanding of the types of

genetic defects that sometimes result in peripheral nerve disorders.

" As the function of each new gene comes to light, a picture is emerging about

the

gene and protein families that underlie different forms of Charcot-Marie-Tooth

disease and perhaps other nervous system diseases as well, " study first author

Dr. Stephan Zuchner, an assistant professor of psychiatry, said in a prepared

statement.

CMT is one of the most common hereditary disorders, affected about one in every

2,500 people. Symptoms included weakening of the muscles in the feet and

hands linked to a lack of stimulation from the nerves. This weakening eventually

spreads to the arms and legs. Physical therapy and moderate activity to

maintain

muscle strength are the only available treatments for the disease.

More information

The Muscular Dystrophy Association has more about Charcot-Marie-Tooth

disease.

Gene Defect Linked to

Familial Nerve Disorder

MONDAY, Jan. 31 (HealthDayNews) -- A

defect in a gene called dynamin 2 causes

one form of the inherited nerve disorder

Charcot-Marie-Tooth (CMT) disease,

according to a new study.

Researchers at Duke University's Center

for Human Genetics, say they have also

identified a previously unknown association

between CMT and a deficiency of white

blood cells. This suggests defects in dynamin 2 may be linked to both

conditions.

Dynamin 2 fulfills a number of functions in cells throughout the

body, but this is

the first time it has been implicated in human disease. The study

appears in the

Jan. 30 issue of Nature Genetics.

The finding, along with earlier research, provides scientists with

new information

about the nervous system and may offer a better understanding of the

types of

genetic defects that sometimes result in peripheral nerve disorders.

" As the function of each new gene comes to light, a picture is

emerging about the

gene and protein families that underlie different forms of

Charcot-Marie-Tooth

disease and perhaps other nervous system diseases as well, " study

first author

Dr. Stephan Zuchner, an assistant professor of psychiatry, said in a

prepared

statement.

CMT is one of the most common hereditary disorders, affected about

one in every

2,500 people. Symptoms included weakening of the muscles in the feet

and

hands linked to a lack of stimulation from the nerves. This weakening

eventually

spreads to the arms and legs. Physical therapy and moderate activity

to maintain

muscle strength are the only available treatments for the disease.

More information

The Muscular Dystrophy Association has more about Charcot-Marie-Tooth

disease.

Gene Defect Linked to

Familial Nerve Disorder

MONDAY, Jan. 31 (HealthDayNews) -- A

defect in a gene called dynamin 2 causes

one form of the inherited nerve disorder

Charcot-Marie-Tooth (CMT) disease,

according to a new study.

Researchers at Duke University's Center

for Human Genetics, say they have also

identified a previously unknown association

between CMT and a deficiency of white

blood cells. This suggests defects in dynamin 2 may be linked to both

conditions.

Dynamin 2 fulfills a number of functions in cells throughout the

body, but this is

the first time it has been implicated in human disease. The study

appears in the

Jan. 30 issue of Nature Genetics.

The finding, along with earlier research, provides scientists with

new information

about the nervous system and may offer a better understanding of the

types of

genetic defects that sometimes result in peripheral nerve disorders.

" As the function of each new gene comes to light, a picture is

emerging about the

gene and protein families that underlie different forms of

Charcot-Marie-Tooth

disease and perhaps other nervous system diseases as well, " study

first author

Dr. Stephan Zuchner, an assistant professor of psychiatry, said in a

prepared

statement.

CMT is one of the most common hereditary disorders, affected about

one in every

2,500 people. Symptoms included weakening of the muscles in the feet

and

hands linked to a lack of stimulation from the nerves. This weakening

eventually

spreads to the arms and legs. Physical therapy and moderate activity

to maintain

muscle strength are the only available treatments for the disease.

More information

The Muscular Dystrophy Association has more about Charcot-Marie-Tooth

disease.

Gene Defect Linked to

Familial Nerve Disorder

MONDAY, Jan. 31 (HealthDayNews) -- A

defect in a gene called dynamin 2 causes

one form of the inherited nerve disorder

Charcot-Marie-Tooth (CMT) disease,

according to a new study.

Researchers at Duke University's Center

for Human Genetics, say they have also

identified a previously unknown association

between CMT and a deficiency of white

blood cells. This suggests defects in dynamin 2 may be linked to both

conditions.

Dynamin 2 fulfills a number of functions in cells throughout the

body, but this is

the first time it has been implicated in human disease. The study

appears in the

Jan. 30 issue of Nature Genetics.

The finding, along with earlier research, provides scientists with

new information

about the nervous system and may offer a better understanding of the

types of

genetic defects that sometimes result in peripheral nerve disorders.

" As the function of each new gene comes to light, a picture is

emerging about the

gene and protein families that underlie different forms of

Charcot-Marie-Tooth

disease and perhaps other nervous system diseases as well, " study

first author

Dr. Stephan Zuchner, an assistant professor of psychiatry, said in a

prepared

statement.

CMT is one of the most common hereditary disorders, affected about

one in every

2,500 people. Symptoms included weakening of the muscles in the feet

and

hands linked to a lack of stimulation from the nerves. This weakening

eventually

spreads to the arms and legs. Physical therapy and moderate activity

to maintain

muscle strength are the only available treatments for the disease.

More information

The Muscular Dystrophy Association has more about Charcot-Marie-Tooth

disease.

Gene Defect Linked to

Familial Nerve Disorder

MONDAY, Jan. 31 (HealthDayNews) -- A

defect in a gene called dynamin 2 causes

one form of the inherited nerve disorder

Charcot-Marie-Tooth (CMT) disease,

according to a new study.

Researchers at Duke University's Center

for Human Genetics, say they have also

identified a previously unknown association

between CMT and a deficiency of white

blood cells. This suggests defects in dynamin 2 may be linked to both

conditions.

Dynamin 2 fulfills a number of functions in cells throughout the

body, but this is

the first time it has been implicated in human disease. The study

appears in the

Jan. 30 issue of Nature Genetics.

The finding, along with earlier research, provides scientists with

new information

about the nervous system and may offer a better understanding of the

types of

genetic defects that sometimes result in peripheral nerve disorders.

" As the function of each new gene comes to light, a picture is

emerging about the

gene and protein families that underlie different forms of

Charcot-Marie-Tooth

disease and perhaps other nervous system diseases as well, " study

first author

Dr. Stephan Zuchner, an assistant professor of psychiatry, said in a

prepared

statement.

CMT is one of the most common hereditary disorders, affected about

one in every

2,500 people. Symptoms included weakening of the muscles in the feet

and

hands linked to a lack of stimulation from the nerves. This weakening

eventually

spreads to the arms and legs. Physical therapy and moderate activity

to maintain

muscle strength are the only available treatments for the disease.

More information

The Muscular Dystrophy Association has more about Charcot-Marie-Tooth

disease.

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