Re: IVG treatment

[Guest guest]

Becky,

IVG therapy is a treatment for CIDP and immune related neuropathies, not for

CMT. If IVG therapy helps your husband, then he has been misdiagnosed. Read

below. If you search under CIDP, you will find more information. ~ Gretchen

Neurology 2002;59:S33-S40

© 2002 American Academy of Neurology

Neurology supplements are not peer-reviewed. Information contained in

Neurology supplements represent the opinions of the authors and are not endorsed

by nor do they reflect the views of the American Academy of Neurology,

Editor-in-Chief, or Associate Editors of Neurology.

Intravenous gammaglobulin (IVIg) for treatment of CIDP and related

immune-mediated neuropathies

H. Brannagan, III, MD

From the Peripheral Neuropathy Center, Department of Neurology and Neuroscience,

Weill Medical College of Cornell University, New York, NY.

Intravenous immune globulin (IVIg) is considered an effective and safe treatment

for autoimmune neuropathies, especially in comparison to the alternative

treatments such as corticosteroids, chemotherapy, and plasmapheresis. Patients

are frequently given a standard induction dose of 2 g/kg, which may be followed

by maintenance therapy as needed. Mild infusion-related reactions are frequent

but these can often be controlled by slowing the infusion rate or by symptomatic

medications. Serious adverse effects are rare and can include thromboembolic

events, renal failure, anaphylaxis, or septic meningitis. Patients with IgA

deficiency are at risk for anaphylaxis. Immobility, increased serum viscosity,

and preexisting vascular disease can increase the risk for thromboembolic

events. Preexisting renal insufficiency or the use of sucrose-containing IVIg

preparations can increase the risk for renal failure, and patients with migraine

are at risk for development of aseptic meningitis. Screening patients for risk

factors that predispose to development of adverse events may reduce the

incidence of complications.

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