In answer to questions about Minocycline

[Guest guest]

After posting several times in various groups about my taking Minocycline, I received several emails asking for information about Minocycline. This gives me an opportunity to clarify a couple of points. I have included one excellent email and will use it to answer the questions I have received:Q: I was wondering about the minocycline.

Have you already started to take this?"A: Yes. One month in.Q: You are female correct? A: Yes. That is my impression, and the facts seem to bear this out :-)

Q: I only happened across this antibiotic recently. I have been unsuccessful in finding a Dr. to treat my Morgellons so I've been doing it myself. I have knocked it back considerably with dewormers, ketoconazole, flagyl and several antibiotics as well as all the baths and herbs. I get my antibiotics from lets just say a non people place. I recently came across the minocycline and had never heard of it. I did some research on

it and found a study or two that thought this might be a more appropriate antibiotic for Spirochetes. However, I could not find any long term or definitive research about the drug. What I did find though was a study about how this

antibiotic may be more appropriate for neurological Spirochetes because

it goes more readily to the brain. However, the study that I read said that because of this, it was more likely to cause nervous system or brain side effects. I think the ones mentioned were dizziness, nausea, confusion, etc. However, it mentioned in studies that these effects seemed to be much more common in WOMEN and not as prominent in men. Made

me very curious as to why this might be. I suffer these symptoms anyway

because of Morgellons and they have been really bad at times. In fact one of my worst symptoms is a narcolepsy type episode that comes and goes at certain times and is horrible after I eat. I am guessing that neurological symptoms

are my major symptoms. I have been considering trying the minocycline but since reading the study, have been reluctant to do so. So I was wondering if you could enlighten me on your experience thus far with this antibiotic and the dosage and

frequency you are taking. I think in a previous post you stated 100mg once per day, correct? Thanks.A: I'm familiar with non people places, lol! I take one capsule of Minocycline a day, at least an hour before or after consuming any food with calcium. I have experienced only mild yeast infection symptoms which, because I have been using Gordon's F-Zymes for 14 months and did not have a yeast problem going into my Minocycline treatment, I easily knocked out (hope it remains easy) with a warm glass of water with a teaspoon of baking soda in it. That is the only effect or side effect other than the herxing that I have experienced. The herxing was ongoing due to the F-zymes, which I have continued, but has increased since I began taking the Minocycline, including more specific localized intense and temporary body aches, especially in my feet; and an increase in the rash on my skin which I remedy by using the F-Zyme spray and "rubbing out" what has surfaced and is acting up on the surface,

causing the rash symptoms. As for your gender question, I do not know the answer. As for your questions about the Minocycline itself, I can tell you no more than you can read for yourself in an MSDS. Here is one of several online that I found for the Minocycline: http://www.drugbank.ca/drugs/DB01017Here is an extract from this link of the information I think best explain why my LLMD prescribed Minocycline. I have not listed side effects as you already did that for us:Indication

For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.

Pharmacodynamics

Minocycline, the most lipid soluble and most active tetracycline

antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Although minocycline's broader spectrum of activity, compared

to other members of the group, includes activity against Neisseria meningitidis,

its use as a prophylaxis (preventive measure) is no longer recommended due to side effects (dizziness and vertigo)...The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase, an inflammatory enzyme associated with brain aging.

Mechanism of action

Minocycline passes directly through the lipid bilayer or passively

diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.

Absorption

Rapidly absorbed from the gastrointestinal tract and absorption is

not significantly impaired by ingestion of food or milk. Oral bioavailability is 100%.Kajay

[Guest guest]

Hi thanks Kayjay, great information. Is this what your LLMD prescribed for you?

Terry

>

> After posting several times in various groups about my taking Minocycline, I

received several emails asking for information about Minocycline. This gives me

an opportunity to clarify a couple of points. I have included one excellent

email and will use it to answer the questions I have received:

>

>

> Q: I was wondering about the minocycline. Have you already started to take

this? "

> A: Yes. One month in.

>

> Q: You are female correct?

> A: Yes. That is my impression, and the facts seem to bear this out :-)

>

> Q: I only

> happened across this antibiotic recently. I have been unsuccessful in

> finding a Dr. to treat my Morgellons so I've been doing it myself. I

> have knocked it back considerably with dewormers, ketoconazole, flagyl

> and several antibiotics as well as all the baths and herbs. I get my

> antibiotics from lets just say a non people place. I recently came

> across the minocycline and had never heard of it. I did some research on it

and found a study or two that thought this might be a more

> appropriate antibiotic for Spirochetes. However, I could not find any

> long term or definitive research about the drug. What I did find though

> was a study about how this antibiotic may be more appropriate for neurological

Spirochetes because it goes more readily to the brain. However, the study that I

read said

> that because of this, it was more likely to cause nervous system or

> brain side effects. I think the ones mentioned were dizziness, nausea,

> confusion, etc.� However, it mentioned in studies that these effects

> seemed to be much more common in WOMEN and not as prominent in men. Made me

very curious as to why this might be. I suffer these symptoms anyway because of

Morgellons and they have been really bad at times. In fact

> one of my worst symptoms is a narcolepsy type episode that comes and

> goes at certain times and is horrible after I eat. I am guessing that

neurological symptoms are my major symptoms. I have been considering trying the

minocycline

> but since reading the study, have been reluctant to do so. So I was

> wondering if you could enlighten me on your experience thus far with

> this antibiotic and the dosage and frequency you are taking. I think in a

previous post you stated 100mg

> once per day, correct? Thanks.

>

> A: I'm familiar with non people places, lol! I take one capsule of Minocycline

a day, at least an hour before or after consuming any food with calcium. I have

experienced only mild yeast infection symptoms which, because I have been using

Gordon's F-Zymes for 14 months and did not have a yeast problem going into my

Minocycline treatment, I easily knocked out (hope it remains easy) with a warm

glass of water with a teaspoon of baking soda in it. That is the only effect or

side effect other than the herxing that I have experienced. The herxing was

ongoing due to the F-zymes, which I have continued, but has increased since I

began taking the Minocycline, including more specific localized intense and

temporary body aches, especially in my feet; and an increase in the rash on my

skin which I remedy by using the F-Zyme spray and " rubbing out " what has

surfaced and is acting up on the surface, causing the rash symptoms. As for your

gender question, I do not

> know the answer. As for your questions about the Minocycline itself, I can

tell you no more than you can read for yourself in an MSDS. Here is one of

several online that I found for the Minocycline:

>

> ��� ��� http://www.drugbank.ca/drugs/DB01017

>

> Here is an extract from this link of the information I think best explain why

my LLMD prescribed Minocycline. I have not listed side effects as you already

did that for us:

>

>

> Indication For the treatment of infections caused by susceptible strains of

> microorganisms, such as Rocky Mountain spotted fever, typhus fever and

> the typhus group, Q fever, rickettsial pox and tick fevers caused by

> Rickettsiae, upper respiratory tract infections caused by Streptococcus

pneumoniaeand for the treatment of asymptomatic carriers of Neisseria

meningitidis.

> Pharmacodynamics Minocycline, the most lipid soluble and most active

tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline.

> Minocycline's effects are related to the inhibition of protein

> synthesis. Although minocycline's broader spectrum of activity, compared to

other members of the group, includes activity against Neisseria meningitidis,

its use as a prophylaxis (preventive measure) is no longer recommended due to

side

> effects (dizziness and vertigo)...The

> neuroprotective action of minocycline may include its inhibitory effect

> on 5-lipoxygenase, an inflammatory enzyme associated with brain aging.

> Mechanism of action Minocycline passes directly through the lipid bilayer or

passively diffuses through porin channels in the bacterial membrane.

> Tetracyclines like minocycline bind to the 30S ribosomal subunit,

> preventing the binding of tRNA to the mRNA-ribosome complex and

> interfering with protein synthesis.

> Absorption Rapidly absorbed from the gastrointestinal tract and absorption is

not significantly impaired by ingestion of food or milk. Oral

> bioavailability is 100%.

> Kajay

>