Guest guest Posted December 16, 2001 Report Share Posted December 16, 2001 Very good article ! On Sun, 16 December 2001, " " wrote: > > From The New York Times Magazine, December 16, 2001 > > " Pain, the Disease " > By Thernstrom: > > http://www.nytimes.com/2001/12/16/magazine/16PAIN.html > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 17, 2001 Report Share Posted December 17, 2001 > http://www.nytimes.com/2001/12/16/magazine/16PAIN.html? ex=1009542904 & ei=1 & en > =0 > Is this not a facinating article!!! I thought it was perculiar that my LLMD wanted me to continue taking Prozac....now I see why. This would be a really good article to have on hand somewhere to attatch to a dissability application. Really makes sense to me with my fibro. pain and feet peripheral neuropathy. DD > December 16, 2001 > Pain, the Disease > By MELANIE THERNSTROM > > A modern chronicler of hell might look to the lives of chronic-pain patients > for inspiration. Theirs is a special suffering, a separate chamber, the > dimensions of which materialize at the New England Medical Center pain > clinic in downtown Boston. Inside the cement tower, all sights and sounds of > the neighborhood -- the swans in the Public Garden, the lanterns of > Chinatown -- disappear, collapsing into a small examining room in which > there are only three things: the doctor, the patient and pain. Of these, as > the endless daily parade of desperation and diagnoses makes evident, it is > pain whose presence predominates. > > ''Yes, yes,'' sighs Dr. Carr, who is the clinic's medical director. > ''Some of my patients are on the border of human life. Chronic pain is like > water damage to a house -- if it goes on long enough, the house collapses. > By the time most patients make their way to a pain clinic, it's very late.'' > What the majority of doctors see in a chronic-pain patient is an > overwhelming, off-putting ruin: a ruined body and a ruined life. It is > Carr's job to rescue the crushed person within, to locate the original > source of pain -- the leak, the structural instability -- and begin to > rebuild: psychically, psychologically, socially. > > For leaders in the field like Carr, this year marks a critical watershed. In > January, the Joint Commission on Accreditation of Healthcare Organizations, > the basic national health care review board, implemented the first national > standards requiring pain assessment and control in all hospitals and nursing > homes. Standards for evaluating and managing pain in lab animals have long > been tightly regulated, but curiously there had never before been any legal > equivalent for people. Maine took the further step last year of passing its > own legislation requiring the aggressive treatment of pain, and California > and other states are considering following suit. > > ''It's a field on the verge of an explosion,'' Carr says. ''There's no area > of medicine with more growth and more public interest. We've come far enough > scientifically to see how far we have to go.'' > > Chronic pain -- continuous pain lasting longer than six months -- afflicts > an estimated 30 million to 50 million Americans, with social costs in > disability and lost productivity adding up to more than $100 billion > annually. However, only in recent years has it become a focus of research. > There used to be no pain specialists because pain had always been understood > as a symptom of underlying disease: treat the disease and the pain should > take care of itself. Thus, specializing in pain made no more sense than > specializing in fever. Yet the actual experience of patients frequently > belied this assumption, for chronic pain often outlives its original causes, > worsens over time and appears to take on a puzzling life of its own. > > Research has begun to shed light on this: unlike ordinary or acute pain, > which is a function of a healthy nervous system, chronic pain resembles a > disease, a pathology of the nervous system that produces abnormal changes in > the brain and spinal cord. New technology, like functional imaging, which is > generating the first portraits of brains in action, is revealing the nature > of pain's pathology. > > Far from being simply an unpleasant experience that people should endure > with a stiff upper lip, pain turns out to be harmful to the body. Pain > unleashes a cascade of negative hormones like cortisol that adversely affect > the immune system and kidney function. Patients treated with morphine heal > more quickly after surgery. A recent study suggests that adequate > cancer-pain treatment may influence the prospects for survival: rats with > tumors given morphine actually live longer than those that do not receive > it. > > > Paradigm shifts occur slowly; if arriving at a new medical conception of > pain has been difficult and protracted, disseminating the knowledge will be > more so. Pain treatment belongs primarily in the hands of ordinary > physicians, most of whom know little about it. Less than 1 percent of them > have been trained as pain specialists, and medical schools and textbooks > give the subject very little attention. The primary painkillers -- opiates, > like OxyContin -- are widely feared, misunderstood and underused. (A 1998 > study of elderly women in nursing homes with metastatic breast cancer found > that only a quarter received adequate pain treatment; one-quarter received > no treatment at all.) > > While the undertreatment of pain has led to lawsuits -- recently, a > California court issued a judgment against a Bay Area internist for > undertreating a terminally ill patient's cancer pain -- so has the > overprescribing of OxyContin in cases of patient abuse. It takes only a few > lawsuits -- along with the threat of Drug Enforcement Administration > oversight and regulation -- to exert a chilling effect on prescribing > practices. ''Doctors feel damned if they do and damned if they don't,'' says > Dr. Fishman, chief of the division of pain medicine at the University > of California at Medical Center. ''The enormous confusion about pain > has led to the hysteria around opiates.'' > > Dr. Mickle, a family doctor in rural Pennsylvania, describes the > leeriness most physicians feel about treating pain: ''Is it objective or > subjective? How do you know you're not being tricked or taken advantage of > to get narcotics? And chronic-pain patients are, generally, well -- a pain. > Most doctors' reaction to a patient with chronic pain is to try to pass them > off to someone who's sympathetic.'' > > And what makes a doctor sympathetic to pain? > > ''Someone who has pain himself,'' Mickle says. ''Or has an intellectual > interest -- who isn't interested in immediate results, doesn't want to make > money, has a lot of degrees. There's one in a lot of communities, but then > they get all the pain patients sent to them and eventually they burn out and > quit.'' > > > Carr's interest in pain began as an intellectual one. After training > as an internist and endocrinologist, he published a landmark study in 1981 > of runners, which showed that exercise stimulates beta-endorphin production, > leading to a ''runner's high'' that temporarily anesthetizes the runner. He > began to wonder: if the runner's high is an example of how a healthy body > successfully modulates pain, what abnormality leads to chronic pain? He did > a third residency in anesthesia and pain medicine, became a founder of the > multidisciplinary pain clinic at Massachusetts General Hospital and a > director of the American Pain Society. Six years ago, he moved to Tufts and > set up a pain clinic (which loses money) and created the country's first > master's program in pain for health professionals. > > Every pain patient is a testament to the dangers of the conservative > wait-it-out approach to pain, as a day spent in Carr's clinic demonstrates. > But it is the last patient of the day, Lee Burke, whose story proves the > most instructive, because her diagnosis turns out to be so simple, while the > forces that worked against it being made earlier were so complex. > > Seven years ago, Burke -- a delicately featured 56-year-old woman in a blue > cotton sweater that picks up the blue of her eyes and the gray in her > hair -- learned she had one of the most survivable varieties of brain > tumors, a growth known as an acoustic neuroma behind her left ear. The > recovery period from the surgery to remove it was supposed to be a mere > seven weeks. Instead, she awoke from surgery with an unforeseen problem. She > had headaches -- lancinating lightning, hot pain -- that knocked her out for > periods ranging from four hours to four days. She never returned to her job > as an executive at a real-estate company. When pain came between her and her > husband, she left him -- and her money and her home. ''It was easier to be > alone with the pain,'' Burke says. > > Carr asks her to describe the headaches. Like most of the 100-odd patients I > observed in various pain clinics trying to describe their suffering, Burke > seems stumped by the question. Therein lies a specific damnation of pain. As > Elaine Scarry writes in her seminal book, ''The Body in Pain,'' pain is not > a linguistic experience; it returns us to ''the world of cries and > whispers.'' Patients grope at far-fetched metaphors. ''A hot, banging pain, > like an ice pick,'' says one. ''It heats up and then sticks it in, again and > again.'' > > Says Burke: ''It's like being slammed into a wall and totally destroyed. It > makes you want to pull every hair out of your head. There's nothing I can do > to defend myself.'' She looks at Carr with the particular stricken > bewilderment -- why and why me? -- that I saw on the faces of so many pain > patients. Pain, from the Latin word for punishment, poena, can feel like the > work of a torturer who must have -- but won't reveal -- a purpose. ''It's > like knives are going through my eyes,'' she says, starting to weep. > > While she blots her face, Carr sits calmly, his concentration fixed, his > hands folded reassuringly across his lap, with the equable, impersonal > kindness of a priest or a cop. Almost all of the patients during the long > day have broken down in their appointments. Perhaps because their lives echo > the chaos in his own blue-collar Irish-Catholic upbringing as the son of an > alcoholic bartender, he says, he isn't alarmed when patients scream at him. > He is neither indifferent to emotion nor distracted by it; you sense at all > times that his focus is on the culprit -- the shape-shifter, the pain. > > Carr asks Burke to close her eyes and taps her head with the corner of an > unopened alcohol wipe. Within a few minutes he has found a clear pattern of > numbness that suggests that one of the main nerves in her face -- the > occipital nerve -- was severed or damaged during her surgery. It is clear > from their differing expressions that Carr regards this as revelation -- the > demystification of her pain -- and that Burke has no idea why. > > Pain makes a child of everyone. Her voice becomes small as she asks, ''If > the nerve was cut, why does it cause pain?'' > > > It is a question researchers have only recently been able to answer. Doctors > used to be so confident that severed nerves could not transmit pain -- > they're severed! -- that nerve cutting was commonly prescribed as a > treatment for pain. But while cut motor nerves can be counted on to cause > paralysis, sensory nerves are tricky. Sometimes they stay dead, causing only > numbness. But sometimes they grow back irregularly or begin firing > spontaneously and produce stabbing, electrical or shooting sensations. > > Picture the pain wiring of the nervous system as an alarm, the body's > evolutionary warning system that protects it from tissue injury or disease. > Acute pain is like a properly working alarm system: the pain proportionally > matches the amount of damage, and it disappears when the underlying problem > does. Chronic pain is like a broken alarm: a wire is cut and the entire > system goes haywire. ''This is true pathology -- the repair doesn't occur, > because the system itself is damaged,'' explains Clifford Woolf, an > M.D.-Ph.D. pain researcher and the director of Mass. General's > neuroplasticity lab. It is called neuropathic pain because it is a pathology > of the nervous system. > > Woolf was the first to answer an old puzzle: why does chronic pain often > worsen over time? Why doesn't the body develop tolerance? Woolf's research > demonstrated that physical pain changes the body in the same way that > emotional loss watermarks the soul. The body's pain system is plastic and > therefore can be molded by pain to cause, yes, more pain. An oft- used > metaphor is that of an alarm continually reset to be more sensitive: first > it is triggered by a cat, then a breeze and then for no reason it begins to > ring randomly or continuously. As recent research by Allan Basbaum at the > University of California at San Francisco has shown, with prolonged injury > progressively deeper levels of pain cells in the spinal cord are activated. > Pain nerves recruit others in a ''chronic-pain windup,'' and the whole > central nervous system revs up and undergoes what Woolf calls ''central > sensitization.'' > > > Lee Burke's records do not even note whether her occipital nerve was cut, > and her surgeon may not have noticed the dental-floss-size nerve. It took > more than a year of complaints before she was referred to Dr. > Acquadro, the director of cancer pain at Mass. General, who noted that she > had severe muscle spasms in her head, neck and shoulders. It was a classic > pain misinterpretation: he seized on muscular pain as the primary problem, > rather than a secondary symptom, and diagnosed tension headaches. > > He treated her with Botox injections, tricyclic antidepressants and migraine > medications. She tried range-of-motion physical therapy, stress- reduction > courses, psychiatric treatment, yoga and meditation and consumed 3,200 > milligrams of ibuprofen a day, along with 12 cups of coffee (caffeine is a > treatment for migraines). He steered her away from opiates with warnings > about their addictive qualities. > > Until recently, opiates were the only serious pain drug available. But > neuropathic pain is the kind of pain for which opiates are the least > effective. In the past few years, however, an alternative has come along. A > new antiseizure drug, Neurontin, has been found to also act as a nerve > stabilizer that can quiet the misfiring nerves responsible for neuropathic > pain. > > When I call her four months after the appointment with Carr, Burke says she > feels 50 percent better from a combination of Neurontin and other drugs. The > muscle spasms -- so rigid that Acquadro compared them to railroad tracks -- > had melted. She no longer needed a snorkel for her daily swim because she > could move her head from side to side again. Of course, you have to be in > terrible pain to find the side effects of pain drugs tolerable. But while > her headaches sometimes required so much Neurontin that she was too dazed to > walk, she was glad to be able to sit up to watch television instead of > simply lying prone in agony. > > ''Dr. Carr is my savior,'' she says. I recall the way she left the > appointment, clasping his hand as if she wanted to kiss it and looking at > him with hope so intense it was hard to watch. > > > ''There's tremendous ignorance about neuropathic pain,'' Woolf says. ''Most > doctors don't know to look for it.'' One confusing factor is that not all > patients with similar conditions develop chronic pain. Neuropathic pain > seems to require genetic vulnerability. Pain clinics are filled with > patients with ordinary conditions and extraordinary pain. M.R.I.'s show only > bones and tissue; doctors might look at a patient's scan and say, ''Your > back looks fine -- the muscle swelling is gone'' or ''The bone's all > healed,'' and conclude there is no reason for pain. But the pain is not in > the muscles or bones; it is in the invisible hydra of the nerves. > > Of course, not all chronic pain is neuropathic -- there is inflammatory > pain, for example, or muscular pain. But many chronic-pain conditions, like > backache, which was once assumed to be wholly musculoskeletal, are now > thought to have a neuropathic component. > > About 10 percent of women used to complain of chronic pain following radical > mastectomies. Their pain had always been interpreted as a psychological > phenomenon: they were just ''missing'' their breasts. But in the early > 1980's, Dr. Kathleen Foley at Memorial Sloan-Kettering Cancer Center in New > York identified the pain as being caused by the severing of a major thoracic > nerve during surgery, and the technique was revised. > > Doctors warn patients of many risks, from death to scarring, but rarely > mention the not-uncommon side effect of chronic pain. The life of one of > Carr's patients was ruined by having a nerve nicked during plastic surgery > to correct protruding ears. Another acquired chronic chest pain after being > treated in a hospital for a collapsed lung when a tube was inserted in her > chest -- one of the most nerve-rich areas in the body. One especially > poignant category of patients in pain clinics is that of those who have had > surgery specifically to treat chronic -- usually back -- pain where the > surgery leads to new, worse pain, an outcome for which they say they had no > warning. > > > Pain doctors have many theories about why these kinds of things happen, but > the dialogue is frustratingly one-sided. There are no spokesmen for > undertreating pain -- no one advocates not treating pain. > > Although I contacted many of the former doctors of pain patients, it was > rare that one was willing to examine his decisions thoughtfully, as > Acquadro did. It was immediately clear to me that Acquadro, a licensed > dentist as well as an anesthesiologist, was both competent and caring and > that the forces that delayed Burke's treatment were not personal > shortcomings but genuine, pervasive confusions about pain. > > Acquadro thought the pain of all acoustic neuroma patients should manifest > itself similarly, and most of those he had seen did, in fact, ''respond to > simpler, more holistic therapies.'' He had not thought of Neurontin, and he > feared opiates. ''We don't always do patients a favor putting them on > high-dose narcotics,'' he says. ''When a patient is depressed or anxious, > you're leery about narcotics or alcohol. With Lee, I guess I'd have to say I > was being cautious.'' His voice changes -- softens and quiets -- as he gets > to the real point: ''I was afraid.'' > > Like many doctors, he says he felt comfortable with anti- inflammatory drugs, > although the 3,200 milligrams of ibuprofen that Burke took daily put her at > risk for gastrointestinal bleeding. According to the Federal Drug Abuse > Warning Network, anti-inflammatory drugs (including aspirin and Aleve) were > implicated in the deaths of 16,000 people in 2000 because of bleeding ulcers > and related complications. While large doses of the drugs are sometimes > needed to treat inflammation, opiates are a much safer -- and generally more > effective -- analgesic. > > Although far fewer than 1 percent of pain patients using opiates develop any > addictive behavior, opiates have a reputation for being dangerous, and > social biases -- class, race and sex -- influence who is entrusted with > them. Studies by Dr. Payne at Sloan-Kettering show that minorities > are up to three times as likely as others to receive inadequate pain > relief -- and to have their requests for medication interpreted as bad > ''drug-seeking behavior.'' A study conducted by Dr. Breitbart at > Sloan-Kettering found that women with H.I.V. are twice as likely to be > undertreated for pain as men. Many of Carr's patients have some social > strike against them that led their previous doctors to withhold treatment: > two were workers' compensation cases, one was mentally ill, several had > histories of substance abuse, all of them were poor and most were women. > > Women tend to be either less aggressive in demanding pain treatment or to be > aggressive in ways that are misinterpreted as hysteria. The longer pain goes > untreated, the more desperate and crazed the patient becomes -- until those > behaviors look like the problem. Burke recalls that whenever Acquadro sent > her to other specialists -- headache specialists, balance specialists and > behavioral pain-medicine specialists -- she would break down during the > appointments in pain and frustration. ''They all just figured I was a basket > case,'' she says. ''And I was. I was a basket case.'' > > Rather than dismiss her psychic distress, Acquadro seems to have become > overly focused on it, trying to explain her pain through that prism: ''Lee's > pain seemed to be better at the times she was happier, was forming new > relationships or helping others,'' he says. ''And even though she was > motivated and worked hard on stress reduction, the fact remains, she is a > tense person.'' > > Naturally. Everyone who has chronic pain eventually develops anxiety and > depression. Anxiety and depression are not merely cognitive responses to > pain; they are physiologic consequences of it. Pain and depression share > neural circuitry. The hormones that modulate a healthy brain, like serotonin > and endorphins, are the same ones that modulate depression. > Functional-imaging scans reveal similar disturbances in brain chemistry in > both chronic pain and depression. > > ''Chronic pain uses up serotonin like a car running out of gas,'' says > Breitbart. ''If the pain persists long enough, everybody runs out of gas.'' > Thus, Acquadro's not treating Burke's pain aggressively because she was > ''tense'' is like ''not rescuing someone who is drowning because they're > having a panic attack,'' according to Breitbart. Difficulty breathing > triggers panic as reliably as pain causes depression. When serotonin is > inhibited in laboratory animals, morphine ceases to have an analgesic effect > on them. Medications that treat depression also treat pain. Depression or > stressful events can in turn enhance pain. Since Sept. 11, pain clinics have > been fuller. ''If we started putting sugar in the water, it would affect the > diabetics first -- pain patients respond to stress with increased pain,'' > explains Fishman, who also trained as a psychiatrist. But to make > stress reduction a primary strategy for pain treatment is trying to repaint > the walls of a crumbling house. > > > It is an easy mistake to make -- and one I made myself. i developed pain > five years ago for, what seemed to me, absolutely no reason. A fiery > sensation flared in my neck, flowed through my right shoulder and sizzled in > my hand. It didn't feel like normal pain -- it felt like a demon had rested > a hand on my shoulder. Suddenly I tasted brimstone and burning. > > Two years later, an M.R.I. would reveal spinal stenosis, a narrowing of the > spinal canal, and cervical spondylosis, a type of arthritis, both of which > squeeze the nerves and cause pain to radiate into my shoulder and hand. But > in the meantime, I was convinced that if I steadfastly ignored it, the pain > would eventually go its own way. I tried to treat it as a psychological > problem. Many pain patients have had doctors who pathologized them, told > them their pain was unreal; I pathologized myself, hoping my pain was > unreal -- or that it would become so if I treated it as such. > > I analyzed the pain in psychotherapy. I tried acupuncture, massage and > herbal remedies. I read books about conversion hysteria, the placebo effect > and Sufis who thread fishhooks through their pectoral muscles. What I didn't > read was anything that might have actually informed me about my symptoms, > like Fishman's excellent patient-oriented book, ''The War on Pain.'' Nor did > I consult any clarifying Web sites, like painfoundation.org. > > When the pain depressed me, I focused on the depression. I adopted Dr. > E. Sarno's popular creed that muscular tension syndrome is the source of > most back ills and faithfully scrutinized my life for stress. It is one of > those circular self-confirming hypotheses: when I was happy and my pain > light, I took it as confirmation of the correlation; when I was happy but > had a lot of pain, I wondered if I didn't want to be happy. I recall how, > strapped inside the white crypt of the M.R.I. machine for more than an hour, > I tried to calm myself by repeating the motto of my Christian Scientist > grandparents: ''There is no life, truth, intelligence nor substance in > matter. All is infinite Mind and its infinite manifestation.'' But I sensed > the machine was seeing my pain in its own way and that its report would be > irrefutable. My pain would no longer be a tree falling in the forest with no > one to hear it. The greatest fear pain patients have, doctors sometimes say, > is that it is ''all in their heads.'' But infinitely scarier, I thought as I > lay there, is the fear that it isn't. > > This is the new frontier of medicine,'' Clifford Woolf says heatedly in his > clipped South African accent. ''What we're learning is that chronic pain is > not just a sensory or affective or cognitive state. It's a biologic disease > afflicting millions of people. We're not on the verge of curing cancer or > heart disease, but we are closing in on pain. Very soon, I believe, there > will be effective treatment for pain because, for the first time in history, > the tools are coming together to understand and treat it.'' > > The most important tool in his lab at Mass. General -- a vast landscape of > test tubes filled with rat DNA -- is the new ''gene chip'' technology that > identifies which genes become active when neurons respond to pain. ''In the > past 30 years of pain research, we've looked for pain-related genes, one at > a time, and come up with 60. In the past year, using gene-chip technology, > we've come up with 1,500,'' Woolf says happily. ''We're drowning in new > information. All we have to do is read it all -- to prioritize, to find the > key gene, the master switch that drives others.'' > > Woolf is particularly interested in certain abnormal sodium ion channels > that are only expressed in sensory neurons that have been damaged. He > believes he is close -- perhaps a year away -- from identifying which among > these channels is the most important one. Then -- if his animal data applies > to humans -- pharmaceutical companies could design blockers for these > channels, and after the years it takes to develop a new drug, there could be > a cure for neuropathic pain. > > On the table before us in Woolf's lab, a graduate student is piercing the > sciatic nerve of a white rat. The rat is of a pain-sensitive variety, one > prone to developing neuropathic pain. In 10 days, when Woolf cuts open the > rat's brain, he will be able to discern the imprint of the sciatic nerve > injury. There will be corresponding maladaptive changes in the way the brain > processes and generates pain. > > The biggest question of pain research is whether this pathological cortical > reorganization can be undone. A 1997 University of Toronto study has shown > disturbing implications. Taddio compared the pain responses of groups > of infant boys who had been circumcised with and without anesthesia. Four to > six months later, the latter group had a lowered pain threshold, crying more > at their first inoculations -- providing evidence that there is cellular > pain memory of damage to the immature nervous system. > > Terms like ''pathological cortical reorganization'' and ''cellular pain > memory'' have a very ominous ring. Are these children really doomed to be > more sensitive to pain their entire lives? Will a cure for neuropathic pain > help all the people who already have it -- or only prevent others from > developing it? > > Woolf looks at me and hesitates. ''We don't really know,'' he says > tactfully. Another pause. ''In the present state, no.'' However, he says, > even if the damage cannot be undone, treatment could still help suppress the > abnormal sensitivity. ''But obviously, it's going to be much easier to > prevent the establishment of abnormal channels than to treat the ones > already there.'' He sighs, rests his head against his hand. ''Obviously.'' > > I want to ask another question, but I'm overcome by a rare unreporterly > desire. I want him to get back to work. > > > Thernstrom is the author of ''The Dead Girl'' and ''Halfway Heaven: > Diary of a Harvard Murder.'' > > > > > Copyright 2001 The New York Times Company Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 18, 2001 Report Share Posted December 18, 2001 Deborah...posts<<<<<<<< Leave no stone unturned.......and ask questions! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 18, 2001 Report Share Posted December 18, 2001 Deborah posts <<<<<> from an article......<<<<with a stiff upper lip, pain turns out to be harmful to the body. Pain unleashes a cascade of negative hormones like cortisol that adversely affect the immune system and kidney function. Patients treated with morphine heal more quickly after surgery. >>>>>>>>> I have been aware of since, I had major surgery on one off my feet, straightening of bones, cutting of tendons, cutting bone, screws.....etc..........The Dr. prescribed Percoset, and insisted I take it until, when I stopped it the medication......I felt NO pain. I told him I have a high tolerance for pain..........he said that wasn't the point........there are plenty of studies out there that state the body heals a lot faster, if you aren't in PAIN. This article confirms his point..............when you need meds for pain...........take them........... Conniek nwnj Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 26, 2001 Report Share Posted December 26, 2001 Thank you Helen, I needed to hear you today. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2002 Report Share Posted January 4, 2002 Pain, the Disease http://www2.rpa.net/~lrandall/thernstrom.html Quote Link to comment Share on other sites More sharing options...
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