Guest guest Posted October 23, 2000 Report Share Posted October 23, 2000 LONG VENT BE WARNED - sorry, just go onto the next message and ignore this one, it is all boring anyhow, I just had to get it out of my system, shouldve just deleted it after typing it! lol Well, seems as though for many of us here at the moment things are more difficult than usual, I am going to have a selfish gripe: Firstly, I am not at all well, my food allergies are causing my IBS to play up badly, from one extreme to another, though mainly abdominal cramping and pain (BAD, like second stage labour, sometimes like third stage and I have to pant though the pain in a fetal position for three hours or more) I am losing weight at the rate of a kg a week and I am already four kilo's under the minimum weight for my height. I am eating enough to maintain my weight, so don't quite understand what is happening with my weight at the moment. I am weak, dizzy, seriously behind in my uni work, aching all over, stiff, rib pains and back pain, cough (for about 6 weeks now, I have been coughing and then puking - sorry, not a pretty picture, funny thing is, I dont have to cough much to puke, just once or twice and I am gagging, thought this was weird!) I am soo tired, wake up in the morning, again, feeling like a wrung out dishrag. Stay that way all day until nighttime, when I dont feel sleepy at all, and cant sleep during the day as the cute little one in the family prevents this. It is another week before I see the rhuematologist and three weeks till I see the immunlogist. I cant see my GP cause he just recently told me that it is all in my head :-( (slap! LOL) I have just been exterminated from my husbands family, due to a psychologically disturbed sister-in-law, who came into the family a year ago and decided to do her best to destroy my relationship with my inlaws, which she has succeeded in well and truly. I know I have told you about this before, but it is still going on and getting worse. Now my brother in law and parents in law are leaning towards believing all that she is saying about me, things that are outright lies, (such as I was supposedly told her, (my s.i.l) that when I was pregnant, my mother in law tried to manipulate me into having an abortion, this is just an outright fiction) naturally these things are very hurtful to my motherinlaw who doesnt know who to believe, and wants me and my sisterinlaw to sit in a room and have it out, in front of my motherinlaw and my brotherinlaw, so they can be judge and jury and work out who is telling the truth. This girl is dangerous, and I just dont want to put myself through that. Of course my brotherinlaw wants to believe his fiance, so in his eyes, I am already lying. My motherinlaw wants to believe that I am lying, cause she has never really liked me or my daughter anyway, so to sit in a room and have it out, like they want, will be really emotionally damaging to me, and me only, the way I see it. What do you all think? Because only I know the truth, and my sisterinlaw is telling all these outright lies about me, it is only my word against hers. SO I cannot see how anything will get sorted out by a confrontation. Trouble is, my motherinlaw thinks that if I don't do this, then it must be because I am guilty - no win situation in my eyes. To top it all off, my partner has told my motherinlaw that she has always treated me badly, listing off some of the terrible things that she has done and said about me in the past, to him, and she professes not to remember any of it, (selective memory) so in her eyes, we are both lying about her also, which leads her to believe that my sisterinlaw is telling the truth about me. I just cant believe that mymotherinlaw cant remember things she repeatedly said to us only a month ago. I just dont know what is going on, and I cannot see any way out, but to wipe the whole lot of them! Sorry, sorry, sorry! I am rambling and angry, and very tired. I feel so cut up about this, cause I have always turned the other cheek with my inlaws, they have done some awful things to me in the past, and I have always been loyal, now, through the manipulations of someone new to the family, who just recently went cold turkey (against Dr's advice) off major antidepressants which she had been on for yrs, I am considered to be a lier and a manipulater, after 6 yrs in the family. Pissed off and sick..... (and if you got this far, you deserve a medal!!!! or some chocolate! LOL) :-) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2000 Report Share Posted October 23, 2000 ((()))) YUK! I know what it is like to have loonies in the family! I don't even beat around the bush with them anymore, I come straight out and say what I feel. i think that scares them. LOL! Try not to stress yourself out over your pathologically lying sister in law because she is not worth it. She is not worth your time or energy. If your mother in law has any brains she'll know she is lying. Unfortunately, some friends are better off not friends. You could confront her with her lying. Have you done that? Oy. Does this woman not have a life or something? <<<Firstly, I am not at all well, my food allergies are causing my IBS to play up badly, from one extreme to another, though mainly abdominal cramping and pain (BAD, like second stage labour, sometimes like third stage and I have to pant though the pain in a fetal position for three hours or more)>>> Aagh. Do you think the stress of your s.i.l. has something to do with it? So you go from constipation to diarrhea? I get painfull loose stools. It feels like I'm pooping acid. (Ok, this is really gross, sorry) I've only gotten painfull cramping a couple of times, but it's NOT NICE! Do you drink carbonated beverages? Have you been checked out for an ulcer? After complaining about my problems my doctor had me get an upper G.I. and I found out I have GERD. Don't you have that also? <>> Make sure you drink something like Gatoade to replenish your electolites. You loose them fast when you have diarrhea. I " m sending many hugs and prayers!!!! ^,,^ >:< **** @lison Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 23, 2000 Report Share Posted October 23, 2000 Oh , I think your Dr. will probly need to be on Aisha's slapping list. He sounds like a complete jerk. Sorry you have to go thru all this crap with your family on top of all that. Oh and about your MIL selective memory, mine has it too. I think it comes along with all the Mother In Laws. Its like a given to be a mother in law you have to have selective memory. I think both the choices you have stink. Hmm, so maybe we can work on a third choice since the first to suck. Ok, im done now Feel better, and know that YOU are telling the truth. Melinda bitch, complain, moan, don't bother to read! LOL LONG VENT BE WARNED - sorry, just go onto the next message and ignore this one, it is all boring anyhow, I just had to get it out of my system, shouldve just deleted it after typing it! lol Well, seems as though for many of us here at the moment things are more difficult than usual, I am going to have a selfish gripe: Firstly, I am not at all well, my food allergies are causing my IBS to play up badly, from one extreme to another, though mainly abdominal cramping and pain (BAD, like second stage labour, sometimes like third stage and I have to pant though the pain in a fetal position for three hours or more) I am losing weight at the rate of a kg a week and I am already four kilo's under the minimum weight for my height. I am eating enough to maintain my weight, so don't quite understand what is happening with my weight at the moment. I am weak, dizzy, seriously behind in my uni work, aching all over, stiff, rib pains and back pain, cough (for about 6 weeks now, I have been coughing and then puking - sorry, not a pretty picture, funny thing is, I dont have to cough much to puke, just once or twice and I am gagging, thought this was weird!) I am soo tired, wake up in the morning, again, feeling like a wrung out dishrag. Stay that way all day until nighttime, when I dont feel sleepy at all, and cant sleep during the day as the cute little one in the family prevents this. It is another week before I see the rhuematologist and three weeks till I see the immunlogist. I cant see my GP cause he just recently told me that it is all in my head (slap! LOL) I have just been exterminated from my husbands family, due to a psychologically disturbed sister-in-law, who came into the family a year ago and decided to do her best to destroy my relationship with my inlaws, which she has succeeded in well and truly. I know I have told you about this before, but it is still going on and getting worse. Now my brother in law and parents in law are leaning towards believing all that she is saying about me, things that are outright lies, (such as I was supposedly told her, (my s.i.l) that when I was pregnant, my mother in law tried to manipulate me into having an abortion, this is just an outright fiction) naturally these things are very hurtful to my motherinlaw who doesnt know who to believe, and wants me and my sisterinlaw to sit in a room and have it out, in front of my motherinlaw and my brotherinlaw, so they can be judge and jury and work out who is telling the truth. This girl is dangerous, and I just dont want to put myself through that. Of course my brotherinlaw wants to believe his fiance, so in his eyes, I am already lying. My motherinlaw wants to believe that I am lying, cause she has never really liked me or my daughter anyway, so to sit in a room and have it out, like they want, will be really emotionally damaging to me, and me only, the way I see it. What do you all think? Because only I know the truth, and my sisterinlaw is telling all these outright lies about me, it is only my word against hers. SO I cannot see how anything will get sorted out by a confrontation. Trouble is, my motherinlaw thinks that if I don't do this, then it must be because I am guilty - no win situation in my eyes. To top it all off, my partner has told my motherinlaw that she has always treated me badly, listing off some of the terrible things that she has done and said about me in the past, to him, and she professes not to remember any of it, (selective memory) so in her eyes, we are both lying about her also, which leads her to believe that my sisterinlaw is telling the truth about me. I just cant believe that mymotherinlaw cant remember things she repeatedly said to us only a month ago. I just dont know what is going on, and I cannot see any way out, but to wipe the whole lot of them! Sorry, sorry, sorry! I am rambling and angry, and very tired. I feel so cut up about this, cause I have always turned the other cheek with my inlaws, they have done some awful things to me in the past, and I have always been loyal, now, through the manipulations of someone new to the family, who just recently went cold turkey (against Dr's advice) off major antidepressants which she had been on for yrs, I am considered to be a lier and a manipulater, after 6 yrs in the family. Pissed off and sick..... (and if you got this far, you deserve a medal!!!! or some chocolate! LOL) :-) The Being Sick Community Visual problems with colors? Click the link below and select the modify link to your right. Then select the **Send Plain Text Email** option. 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Guest guest Posted October 24, 2000 Report Share Posted October 24, 2000 > LONG VENT BE WARNED - sorry, just go onto the next message and ignore > this one, it is all boring anyhow, I just had to get it out of my > system, shouldve just deleted it after typing it! lol Glad you didn't!!! You tell us to vent, same goes for you too!!! > Firstly, I am not at all well, my food allergies are causing my IBS > to play up badly, from one extreme to another, though mainly > abdominal cramping and pain (BAD, like second stage labour, sometimes > like third stage and I have to pant though the pain in a fetal > position for three hours or more) Are you sure you have IBS? Or could it be Infectious Colitis??? I have IBS now. I had Infectious Colitis years ago and the symptoms you have just described sound like that! http://onhealth.webmd.com/conditions/resource/conditions/item%2C272.asp It is another week before I see the > rhuematologist and three weeks till I see the immunlogist. I cant see > my GP cause he just recently told me that it is all in my head :-( > (slap! LOL) I'll give him a good hard slap for You. Call the specialist and see if you can get in sooner. > are very hurtful to my motherinlaw who doesnt know who to believe, Seems like she needs to open her eyes. Did she distrust you in the 6 years prior to this? > wants me and my sisterinlaw to sit in a room and have it out, in > front of my motherinlaw and my brotherinlaw, so they can be judge and > jury and work out who is telling the truth. I don't know about that. You will have to decide yourself if you have to prove yourself to them. { I wouldn't, if I did not do anything wrong! just my opinion!! } > This girl is dangerous, and I just dont want to put myself through > that. Of course my brotherinlaw wants to believe his fiance, so in > his eyes, I am already lying. > My motherinlaw wants to believe that I am lying, cause she has never > really liked me or my daughter anyway, so to sit in a room and have > it out, like they want, will be really emotionally damaging to me, My opinion, adios ex-in-laws!!! I don't have to prove my self to no one if my last few years have met nothing at all to you and you don't know me by now... Trouble is, my motherinlaw thinks that if I > don't do this, then it must be because I am guilty - no win situation > in my eyes. > To top it all off, my partner has told my motherinlaw that she has > always treated me badly, listing off some of the terrible things that > she has done and said about me in the past, to him, and she professes > not to remember any of it, (selective memory) so in her eyes, we are > both lying about her also, which leads her to believe that my > sisterinlaw is telling the truth about me. I just cant believe that > mymotherinlaw cant remember things she repeatedly said to us only a > month ago. I just dont know what is going on, and I cannot see any > way out, but to wipe the whole lot of them! You have to live with yourself on whatever you decide to do. I just plain don't see mine, and they live 1/4 mile from us. When we were having get togethers, I was cival and that was that. When I Had to have the holidays here I did not invite my brother-in-law to my home as I did not want him here. I did not want to be degraded in my own home! And that is exactly what he would have done. My mother-in-law wasn't to happy her favorite son and family wasn't invited, but oh well, if she wanted him then she can have the gathering at her home. And she did. Didn't always invite us but no skin off my nose, I didn't want to go any ways. When she finally realised that then we were invited again. > Sorry, sorry, sorry! > I am rambling and angry, and very tired. Doesn't help your health any either! Being so upset can do a lot of damage to yourself when you are already ill. But you can let it all out here and no one here is going to hollar at you and degrade you in this family... > Pissed off and sick..... > (and if you got this far, you deserve a medal!!!! or some chocolate! > LOL) > > :-) I'll take a Huge Hug instead! You deserve a medal for putting up with your in-laws. Your a grown women and they don't rule your home. Stand up for you!! You will feel better and you won't regret it at all... {At least I don't} {{{{{Big Gentle Hugs To You and Your Partner}}}}} Love Helen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2000 Report Share Posted October 24, 2000 Oh , I am so sorry you are going through so much pain. {{{{{{BIG HUGS}}}} I swear having to have the physical is bad enough without having emotional as well. There is no sence in you having to be in this kind of pain. You really need to get another doctor. And maybe a baseball bat to take along on visits to dare them to treat you like this. LOL I had to make the choice to just stay away from my in-laws. I am polite when I have contact with them but, I do not go to their home or around them any more. I put up with and forgave as long as I could. There comes a point for all of us when we can take no more and, we have to back away from family or friends that hurt us. My in-laws were my good friends brfore I married their son. What put a wedge between us was the grand child and the ex. They felt they didn't see their grandson as much and he should be there not here with his daddy and I, they paired with the ex and made life a living hell. You would not belive! This story would be a book. LOL I think too many of us could talk to you about family betrayal and the hurt they inflict on us. I am sorry you, or anyone has to go through this. Sadly too many can also understand doctors not listening to you or beliving you. It is our lives, we know what we feel. I went to the doctor once, not being able to see well enough to read a road sign, sitting right beside it. Stupid doctor came in and said, " young lady,do you realize that you are too fat? " . Well DUH doc, you went to school how long to know that? I told him off but good. LOL He dcided in his wisdom that I was having a migrain headache. No pain mind you. I just love the doctors who decide that it is in your head, or don't know so they make something up. Hang in there dear one. I wish I could ease the suffering for you. ((((HUGS))))) Dorie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 24, 2000 Report Share Posted October 24, 2000 Well with a title like that Rach, I had to read it! lmao "I am going to have a selfish gripe:" You go girl!! "Firstly, I am not at all well <snip> I am losing weight at the rate of a kg a week and I am already four kilo's under the minimum weight for my height." So when are you coming to Sydney to see my specialists??? PLEASE! Sudden and drastic weightloss (which is what you described) is very serious hon. Please get yourself to a decent GP and get some help babe! This is not good. "I cant see my GP cause he just recently told me that it is all in my head" Well he obviously has nothing in his, so get another Dr. "I am weak, dizzy, aching all over, stiff, rib pains and back pain, cough (for about 6 weeks now, I have been coughing and then puking - sorry, not a pretty picture, funny thing is, I dont have to cough much to puke, just once or twice and I am gagging, thought this was weird!) I am soo tired, wake up in the morning, again, feeling like a wrung out dishrag. Stay that way all day until nighttime, when I dont feel sleepy at all, and cant sleep during the day as the cute little one in the family prevents this. It is another week before I see the rhuematologist and three weeks till I see the immunlogist." *SCREAMS* (This is so much like me its scary! *whispers get an ACE test*) Why are you seeing a rhuemy? Any chance you can get an appt with my immunologist same day you see Dwyer?? "I have just been exterminated from my husbands family" *LOUDER SCREAMS* Dont you just want to punch them? "I cannot see any way out, but to wipe the whole lot of them!" I did that to my in-laws and my extended family and vote *YES* on that one. It was horrible to have to do, and it hurt so much and still does, but it is so much better without them in my life. Its such a relief. You have enough going on without family shoving those knives in your back. Walk away - you dont need it. "Sorry, sorry, sorry!" No need to ever apologise for writing! This is a support group remember! *gentle hugs* (and if you got this far, you deserve a medal!!!! or some chocolate! LOL) LOL - the Olympic City here!! I am sure I could still pay someone for a medal! Hang in there Rach, and please, get yourself to a Dr ASAP. You sound in deseperate need of some propper medical attention, not this hog wash your GP has put you through. Love ya! *hugs* Aisha (Who has hand selected medical professionals in most fields for your convienience! lmao!!) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2000 Report Share Posted October 25, 2000 could it be Infectious Colitis??? > I have IBS now. I had Infectious Colitis years ago and the symptoms you > have just described sound like that! **Tried to take a look at the link Helen, but my connection is painfully slow tonight, waited a few minutes and gave up, will try again tomorrow, have never heard of infectious colitis, thanks for the link, it may give me some leads. > I'll give him a good hard slap for You. Call the specialist and > see if you can get in sooner. **No chance, they squeezed me in for it, anyway, and I have to travel 3-4 hours to Sydney for it too :-( Hopefully he is worth it though, this will only be my 2nd trip to him, so we will see.... > > > > are very hurtful to my motherinlaw who doesnt know who to believe, > > Seems like she needs to open her eyes. Did she distrust you in > the 6 years prior to this? ***I have never had words with her, in fact she doesnt really talk to me, only perfunctuary stuff. She throws it all at my partner, when she has a problem, and I hear it from him. I have always just turned the other cheek, this time is too much though! She has distrusted me, right from the beginning, as I had a daughter when I met my partner, and in her eyes, I was ruining his life. She gave him hell about it, but has always been sweet as pie to my face. She has called me a lier before, once I bought some clothes for the baby on a three day sale, they were lovely. I was so excited, as they had been very expensive. When she saw them she told my partner that i was spending all his money and I would ruin him, he told her what I had paid for them and she didn't believe it, so went into the store to check up and came back and told my partner that I was lying, cause they were not on sale. She wouldnt believe that they were when I bought them, and wouldnt go and check with the store, cause she wanted to believe that I was a lier and ruining his life. I still sometimes joke when I get a bargain, I ask my partner if he wants to keep the docket to show his mother. It did hurt though, as I am honest to a fault, and cannot bear being thought of as a lier, which is why this new situation hurts so much. > My opinion, adios ex-in-laws!!! I don't have to prove my self to > no one if my last few years have met nothing at all to you and you don't > know me by now... **Yes you are probably right, however I would feel very guilty towards my partner, dividing his family up. When I Had to have > the holidays here I did not invite my brother-in-law to my home as I did > not want him here. I did not want to be degraded in my own home! And that > is exactly what he would have done. ***yes, well we have stated catagorically, that we will not have my SIL in our home, or sit in the same room as her, EVER! We certainly will not be going to their wedding next yr. I will not back down on this, cause she is poison, anyone who can lie like this, is one sick puppy. > > I'll take a Huge Hug instead! HERE THEY ARE>>>>>>>**HUGE HUGS!!!!!!!!!!!!!!!!!****** Thank you thank you thank you, Helen, this is the second time you have made me feel so much better about this inlaw problem, thanks for taking the time to help :-) You are a sweetie! Lots and lots of love :-) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2000 Report Share Posted October 25, 2000 > Oh , I am so sorry you are going through so much pain. {{{{{{BIG > HUGS}}}} ***Thanks Dorie :-) And maybe a baseball bat to take along on > visits to dare them to treat you like this. LOL ***LOL good idea, and when i get taken away in that police car, I will say " Dorie told me to do it!! " LOL > > I had to make the choice to just stay away from my in-laws. I am polite > when I have contact with them but, I do not go to their home or around > them any more. ***THis is how I feel right now, they have no respect for everthing that I stand for, and honesty is the most important characteristic, I feel, that is also why my GP gets up my nose so much, not believing that I am sick GRRRRR! I dont lie! they paired with the ex and made life a living hell. You > would not belive! This story would be a book. LOL ***OH poor you, bad for the kids too! > Sadly too many can also understand doctors not listening to you or > beliving you. *Yes, it is a common refrain around here, I am always amazed that some people actually get a diagnosis, so many Dr's are such losers! > I went to the doctor once, not being able to see well enough to read a > road sign, sitting right beside it. Stupid doctor came in and said, > " young lady,do you realize that you are too fat? " . Well DUH doc, you > went to school how long to know that? I told him off but good. **Good on you Dorie! What was wrong with your eyes? LOL He > dcided in his wisdom that I was having a migrain headache. No pain mind > you. ***HMMM< yes, well that DOES sound like a migraine, no pain and blurry street signs, yes! Dickhead! LMAO, how the hell do you get diagnosed with a migraine with no pain????? Unbelievable! > Hang in there dear one. I wish I could ease the suffering for you. > > ((((HUGS))))) > > Dorie Oh thank you Dorie, you are precious *HUGS* :-) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2000 Report Share Posted October 25, 2000 > " I cant see my GP cause he just recently told me that it is all in my head " > > Well he obviously has nothing in his, so get another Dr. ******LMAO, I am going to, Dwyer said that he sounded " unenlighteded " LOL, and we wouldnt want to see an unenlightended Dr, now would we, so i am gonna ask Dwyer for a referral for a good GP down here. > *SCREAMS* > > (This is so much like me its scary! *whispers get an ACE test*) (whispers back, " I am almost done coughing now Aisha, so I wont need the test now.) Don't worry, just hassling you, what is the ACE test anyway, is it definitive or another of those, you may or may not still have it although the results are neg. kind of test? My personal most hated diagnostic tool, are those dumb tests, when a neg answer may not mean neg! > > Why are you seeing a rhuemy? **Rhuemy is here in ACT, and dumb GP sent me to her, I hated her, cause she said I couldnt do yoga with my hypermobile joints, and I REALLY want to do yoga! I recently asked my GP what exercises I could do to help my loose joints and he looked at me strangely and said any damn exercise you want, just get into it. When I told him what the Rhuemy said about the hypermobility and yoga, and asked him for a referral to someone who could help devise an exercise program for me he thought I had totally lost it and let me know that there was nothing wrong with me and if I wanted to exercise I should just do it. Finally I got pissed off, and stood up, leant on his desk and turned my elbows around backwards, and said " well, can you do that? Every joint in my body does that. Don't you think that may be damaging to my joints, if I exercise incorrectly? " His eyebrows shot up to his hairline and he said he would look into finding someone although I may have to go to Sydney. I said " fine, let me know " GRRRRRRR! Mind you, after a month, the asshole still hasnt contacted me. Any chance you can get an appt with my immunologist same day you see Dwyer?? ***What! This sounds a little full on, seeing two in one day. What would your Dr think if he knew that I did that? I wouldn't be accused of shopping around for an illness would I? I have been accused of that in the past. (when I was told I had a phantom pregnancy, and psychological probs, cause I wouldnt believe that I was not pregnant. 7 months later, I delivered that " phantom " baby! My daughter, now 11 yrs) You have enough going on without family shoving those knives in your back. Walk away - you dont need it. *****True!!!! You can rest assured that neither me or my partner will ever sit in the same room as my SIL again, and we have told everyone that we will not attend their wedding next yr (as if we would get an invite LOL)I am not so sure how to handle the MIL though. > No need to ever apologise for writing! This is a support group remember! *gentle hugs* ***Thanks Aisha :-) > (Who has hand selected medical professionals in most fields for your convienience! lmao!!) ***not sure I would have the mental energy to see your Dr on the same day, and shock horror, I would need a referral from my asshole GP! Toodles :-) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 25, 2000 Report Share Posted October 25, 2000 ******LMAO, I am going to, Dwyer said that he sounded "unenlighteded" LOL, and we wouldnt want to see an unenlightended Dr, now would we, so i am gonna ask Dwyer for a referral for a good GP down here. HAHAHAHA.... Well shit girl, you'd better start looking for someone "not disagreeable" (one of my Dr's fav terms lol) "Don't worry, just hassling you, what is the ACE test anyway, is it definitive or another of those, you may or may not still have it although the results are neg. kind of test?" Well yes and no (am I sounding medical yet??!! lmao) Um.. in brief ACE is a test for inflamation, but it is more specific. Yes it is another elimination test, but there are only a handful of things from it, so if it is raised its significant. I have it done every 6 weeks to monitor disease activity - but its for other stuff too. This is medical description, but easier then me trying to explain it lol. Angiotensin-Converting Enzyme (ACE) (010116)Synonyms ACE; Angiotensin-I-Converting Enzyme Use High in sarcoidosis, more often when the disease is active. Of value in assessing the response of sarcoidosis to corticosteroid therapy. Changes in serum ACE correlate with clinical status and results of gallium scans (which reflect presence and activity of inflammatory granulomatous lesions). Falling ACE level is a favorable prognostic sign. Rising levels may reflect activity uncontrolled by therapy.Limitations Elevations have been reported in about 35% to 80% of cases of sarcoidosis. ACE levels are less likely to be increased with chronic sarcoidosis. Different admixtures of acute and chronic cases may explain some of the apparent variation in reported incidence of elevation in sarcoidosis. Elevations have been found in patients with diabetes mellitus, Gaucher's disease and leprosy. Twenty-five percent of 86 patients with acute histoplasmosis had elevated levels.1 Increased in some patients with primary biliary cirrhosis, amyloidosis, myeloma, some alpha1-antitrypsin variants, Melkersson-Rosenthal syndrome, and hyperthyroidism. It has been found increased in some cases of hyperparathyroidism and in some instances of oncogenic hypercalcemia. Thus, it is not a specific marker for the diagnosis of sarcoidosis.2 Positives are also reported in patients with extrinsic allergic alveolitis, coccidioidomycosis, beryllium disease, asbestosis, silicosis, and alcoholic liver disease.3 ACE activity is decreased during starvation, independent of the level of thyroid activity (as monitored by T3 levels).4Methodology KineticAdditional Information Other abnormalities found in some sarcoidosis patients include elevations of serum alkaline phosphatase, calcium, gamma globulin with polyclonal gammopathy, and hypercalciuria. Serum angiotensin converting enzyme is elevated in 50% of cases of sarcoidosis but not in cases of active tuberculosis or Hodgkin's disease. Increases are less frequent when sarcoidosis is inactive.2 Some 80% to 90% of patients with demonstrably active sarcoidosis have elevated serum ACE. Angiotensin converting enzyme activity is also increased in sarcoid lymph node homogenate. The diagnosis of sarcoidosis is an histopathologic/clinical complex. Noncaseating granulomas must be proven not to be caused by tuberculosis, histoplasmosis, or other microbiologic entities. Berylliosis is a very rare cause of such granulomas. ACE is a dipeptidyl carboxypeptidase. It functions to split dipeptides from the free carboxy end of a variety of polypeptides including angiotensin I and bradykinin. It is especially known for its generation of the octapeptide angiotensin II by releasing the dipeptide histidyl-leucine from angiotensin I. The major site of ACE production is the pulmonary bed of endothelial cells. Thyroid hormone may modulate ACE activity. Both patients with low T3 levels (and clinical hypothyroidism) and patients with anorexia nervosa with associated findings of hypothyroidism may have low serum ACE activity.5,6 Monitoring of ACE levels may have application in assessing risk of pulmonary damage due to use of some antineoplastic agents, in particular bleomycin.7 Serum ACE is decreased in some patients with bronchogenic carcinoma. With response to chemotherapy/radiation therapy the ACE level has been noted to normalize.8 Cerebrospinal fluid ACE is useful in patients with neurosarcoidosis. Elevated serum ACE levels in a case of the uncommon entity, Melkersson-Rosenthal syndrome, probably relate to the sarcoid-like noncaseating granulomas that are found in this condition. ACE levels normalized after successful (clinical management) therapy with methotrexate.9 Serum ACE abnormality has been reported in 20% to 30% of alpha1-antitrypsin variants (MZ, ZZ, and MS Pi types) but in only about 1% of individuals with normal MM Pi type.10 There is evidence that paraquat poisoning (because of its effect on pulmonary capillary endothelium) is associated with elevated serum ACE.11 ***What! This sounds a little full on, seeing two in one day. Well if I have to why dont you? *pokes out tongue* I always see neurologist in morning and immunologist in arvo. It is full on but thats it for another 2 months lol... "What would your Dr think if he knew that I did that?" LOL - well he would try to prove that he is a better Dr! LMAO. Hell how should I know? I dont think he'd judge you though, especially if you told him that I said you should see him!!! LOL (I should get a cut of the fees - like a referal agency!!) "I wouldn't be accused of shopping around for an illness would I?" You are forgetting that my Dr is also a pathologist, so any abormalities mean you are sick. He has never said any of that sort of psycho shit to me. ***not sure I would have the mental energy to see your Dr on the same day, and shock horror, I would need a referral from my asshole GP! Yeah you need a referal so it dont cost you lots, thats the only reason. No referal means no rebate. Otherwise you can still see them (this is what I was told anyhow). It was just a thought to save you from having to come to Sydney twice. But then again Dwyer might be really good?? Hell he is enlightened! LMAO *HUGS* Love Aisha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 26, 2000 Report Share Posted October 26, 2000 > > Well yes and no (am I sounding medical yet??!! lmao) ***YES you sound exactly like most of the Drs' I have seen to date! LOL This is medical description, but easier then me trying to explain it lol. ***From the info, sounds very confusing, so it " can be high with sarcoidosis " " and ACE levels are less likely to be increased with chronic sarcoidosis " This makes about as much sense as tits on a bull! LOL > > ***What! This sounds a little full on, seeing two in one day. > > Well if I have to why dont you? *pokes out tongue* ***Cause I don't wanna, thats why!! Na na nanananana! Well, I have been labelled a hypochondriac for so long it is getting ingrained LOL, if I mentioned to my GP that I wanted a referral to a Dr he may never have heard of, when I have seen Dwyer once, he would commit me, I am sure! > > I always see neurologist in morning and immunologist in arvo. It is full on but thats it for another 2 months lol... > > " What would your Dr think if he knew that I did that? " **My Dr would think that all his suspicions have been confirmed, and I really dont want him to decide definitively that I am a nut wanting a disease, cause I am still trying to get a diagnosis *sob* and need to be taken seriously. Sounds like your Dr has respect for patients, not like my asshole GP! > You are forgetting that my Dr is also a pathologist, so any abormalities mean you are sick. He has never said any of that sort of psycho shit to me. ***SOrry, I have heard nothing else for the last five yrs, only reason I stuck with this guy was that he was prepared to refer me anyway, and I have struck other GP's who won't. SO I am oversensitive I think to all that psychobabble. > Yeah you need a referal so it dont cost you lots, thats the only reason. No referal means no rebate. Otherwise you can still see them (this is what I was told anyhow). ***Oh, didn't know that! Hell he is enlightened! LMAO **WE hope! thanks Aisha, sorry for sounding paranoid about what the Dr's think, however, what they think, is still relevant till you have a diagnosis. if you don't like them then you can tell them to fuck off and go get another Dr. If you do that constantly before a diagnosis, you get a reputation for wanting to hear that you have a disease. My Gp waxed lyrical recently on the many people out there who are nuts and WANT to be sick (asshole) that is when I finally knew that he was a dead duck. He also said, what did Dwyer give you? Zoloft? Yeah, right, so in his opinion the only thing wrong with me is depression. yet I am not depressed (and I live with someone on Zoloft, so I do know what depressed looks like) Prick! Toodles :-) Quote Link to comment Share on other sites More sharing options...
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