Mouse Experiments Link Folic Acid Deficiency To Parkinson's Disease

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Mouse Experiments Link Folic Acid Deficiency To Parkinson's Disease

Mouse experiments suggest that folic acid deficiency could increase the brain's

susceptibility to Parkinson's disease, according to scientists at the National

Institute on Aging.

In the finding, published in the January 2002 issue of the Journal of

Neurochemistry, the investigators fed one group of mice a diet that included

folate, while a second group was fed a diet lacking this vitamin. They then gave

the mice moderate amounts of MPTP, a chemical that can cause Parkinson-like

symptoms. In the mice fed folate, MPTP caused only mild symptoms of disease. But

mice fed the folate-deficient diet developed severe Parkinson-like symptoms.

The scientists found that mice with low amounts of dietary folic acid had

elevated levels of homocysteine in the blood and brain. They suspect that

increased levels of homocysteine in the brain caused damage to the DNA of nerve

cells in the substantia nigra, an important brain structure that produces

dopamine.

Loss of dopamine causes the nerve cells to dysfunction, leaving patients unable

to direct or control their movement in a normal manner. In mice fed adequate

amounts of folate, dopamine-producing nerve cells were able to repair damaged

DNA and counteract the adverse effects of homocysteine. However, similar nerve

cells in folate-deficient mice could not repair extensive DNA damage. As a

result, these cells died.

" This is the first direct evidence that folic acid may have a key role in

protecting adult nerve cells against age-related disease, " said Mark Mattson,

Ph.D., chief of the NIA's Laboratory of Neurosciences. " It is clear from this

study that a deficiency of this vitamin is associated with increased

toxin-induced damage to the dopamine-producing neurons in the mouse brain. "

People who have Parkinson's disease often have low levels of folic acid in their

blood, but it is not clear whether this a result of the disease process or if

they are simply malnourished due to their illness.

But based on this study, Dr. Mattson speculates that consuming adequate amounts

of folic acid-either in the diet or by supplementation-could help protect the

aging brain against Parkinson's and other neurodegenerative diseases. Green

leafy vegetables, citrus fruits and juices, whole wheat bread and dry beans are

good sources of the vitamin.

Food and Drug Administration (FDA) regulations require the addition of folic

acid to enriched breads, cereals, flours, corn meals, pastas, rice, and other

grain products.

Parkinson's disease occurs when certain nerve cells die or become impaired and

can no longer produce dopamine. Without it, individuals can develop tremor or

trembling in hands, arms, legs, jaw, and face; rigidity or stiffness of the

limbs and trunk; bradykinesia, or slowness of movement; and postural instability

or impaired balance and coordination.

Patients may also have difficulty walking, talking, or completing other simple

tasks. The disease is both chronic and progressive.

Parkinson's is not usually inherited, but incidence of the disease increases

with age, with an average onset at about 60 years. It afflicts about 50,000

Americans annually.