Essential fatty acids and their derivatives

[Guest guest]

Current Opinion in Gastroenterology. 21(2):207-215, March 2005.

Essential fatty acids and their derivatives

[Nutrition]

McCowen, C; Bistrian, Bruce R

"Under ordinary circumstances in healthy volunteers, large increases in dietary LA do not result in elevated serum lipid AA concentrations, as the conversion rates are tightly regulated. Similarly, thromboxane formation and platelet aggregation were not persistently influenced by dietary content of LA in a clinical research study of healthy female volunteers given liquid formula diet for 6 weeks [32•]."

32 • Adam O, Wolfram G, Zollner N. Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. Ann Nutr Metab 2003; 47:31-36. Clinical research study of 6 volunteers given liquid formula diets for 6 weeks showing that increasing LA in healthy persons does not increase AA. This may be different in patients with inflammatory disorders.