Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 " The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Kohut ML, Lee W, A, Arnston B, DW, Ekkekakis P, Yoon KJ, Bishop A, Cunnick JE. Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Veterinary Diagnostic and Production Animal Medicine, Iowa State University, USA. mkohut@... The primary goal of this study was to determine whether exercise- associated improvements of the immune response to influenza vaccination were mediated by improvements in psychosocial factors in older adults. At baseline, prior to the exercise intervention, older adult participants were immunized with influenza vaccine. Blood samples collected pre-immunization, 1, 4, and 12 weeks post- immunization were analyzed for anti-influenza antibody, whereas influenza-specific cytokine (IFNgamma) was evaluated at 1 week post- immunization. Depression and sense of coherence were measured pre- immunization. Four weeks post-immunization, participants were randomly assigned to either an aerobic exercise group (n=14) or a control group (n=14). After a 10-month exercise intervention, the immunization, blood collections, and psychosocial measures were repeated. At the post-intervention evaluation, exercise participants had improved scores on depression and sense of coherence. Also post- intervention, exercise participants had a greater increase in antibody and IFNgamma production. After controlling for the effect of both psychosocial measures, the exercise treatment remained significant with respect to antibody titer suggesting that the increases in antibody were not mediated by improvement in the psychosocial factors. In contrast, the enhancement of IFNgamma appeared to be mediated at least in part by the psychosocial factors. After controlling for psychosocial factors, exercise treatment was no longer significantly related to the change in IFNgamma. Taken together, our findings may suggest that the mechanism(s) of exercise- induced improvement in immunocompetence involve both physiological and psychological pathways. " PMID: 15944076 Rodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 Another study in similar vein: " Role of host's antitumor immunity in exercise-dependent regression of murine T-cell lymphoma. Singh MP, Singh G, Singh SM. School of Biotechnology, Banaras Hindu University, Varanasi 221005, India. We have reported that the ascitic growth of a transplantable T cell lymphoma of spontaneous origin, designated as Dalton's lymphoma (DL), is associated with a concomitant immunosuppression. We have also reported that progressive in vivo growth of DL resulted in an inhibition of macrophage functions. In present investigation we report that physical exercise by DL-bearing mice, on a treadmill on a daily basis for various time durations for 10 days, increased the life span along with an inhibition of tumor growth. A significant decrease in the volume of ascitic fluid and number of cells in the tumor was obtained in mice, which underwent exercise. DL cells obtained from exercised groups showed a decreased proliferation in vitro. An augmentation in the percent of cells showing apoptotic morphology and percent specific DNA fragmentation was observed, suggesting that physical exercise increased the incidence of apoptosis in tumor cells. Moreover, macrophages obtained from tumor- bearing mice, which underwent exercise training, showed an augmented tumoricidal activity and production of tumoricidal molecules like interleukin-1 (IL-1), tumor necrosis factor (TNF) and nitric oxide (NO). On the basis of this study it is suggested that the regression of tumor growth consequent to physical exercise training of tumor bearing host, may be due to an exercise-dependent augmentation of macrophage tumoricidal functions. " PMID: 15857662 --- In , " Rodney " <perspect1111@y...> wrote: > " The exercise-induced enhancement of influenza immunity is mediated > in part by improvements in psychosocial factors in older adults. > > Kohut ML, Lee W, A, Arnston B, DW, Ekkekakis P, Yoon > KJ, Bishop A, Cunnick JE. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 And another. In particular note: " Whereas the suppressive effect of heavy training on mucosal immunity is well documented ......... " " Living high-training low altitude training: effects on mucosal immunity. Tiollier E, Schmitt L, Burnat P, Fouillot JP, Robach P, Filaire E, Guezennec C, Richalet JP. Departement de physiologie, IMASSA, 91223 Bretigny-sur-Orge Cedex, France. e.tiollier@... Secretory immunoglobulin A (sIgA) is the major immunoglobulin of the mucosal immune system. Whereas the suppressive effect of heavy training on mucosal immunity is well documented, little is known regarding the influence of hypoxia exposure on sIgA during altitude training. This investigation examined the impact of an 18-day Living high-training low (LHTL) training camp on sIgA levels in 11 (six females and five males) elite cross-country skiers. Subjects from the control group (n=5) trained and lived at 1,200 m of altitude, whereas, subjects from the LHTL group (n=6) trained at 1,200 m, but lived at a simulated altitude of 2,500, 3,000 and 3,500 m (3x6-day, 11 h day(-1)) in hypoxic rooms. Saliva samples were collected before, after each 6-day phases and 2 weeks thereafter (POST). Salivary sIgA, protein and cortisol were measured. There was a downward trend in sIgA concentrations over the study, which reached significance in LHTL (P<0.01), but not in control (P=0.08). Salivary IgA concentrations were still lower baseline at POST (P<0.05). Protein concentration increased in LHTL (P<0.05) and was negatively correlated with sIgA concentration after the 3,000 and 3,500 m-phase and at POST (P<0.05 all). Cortisol concentrations were unchanged over the study and no relationship was found between cortisol and sIgA. In summary, data were strongly suggestive of a cumulative negative effect of physical exercise and hypoxia on sIgA levels during LHTL training. Two weeks of active recovery did not allow for proper sIgA recovery. The mechanism underlying this depression of sIgA could be mediated by neural factors. " PMID: 15765238 Rodney. > > " The exercise-induced enhancement of influenza immunity is mediated > > in part by improvements in psychosocial factors in older adults. > > > > Kohut ML, Lee W, A, Arnston B, DW, Ekkekakis P, Yoon > > KJ, Bishop A, Cunnick JE. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 And another. In particular note: " Whereas the suppressive effect of heavy training on mucosal immunity is well documented ......... " " Living high-training low altitude training: effects on mucosal immunity. Tiollier E, Schmitt L, Burnat P, Fouillot JP, Robach P, Filaire E, Guezennec C, Richalet JP. Departement de physiologie, IMASSA, 91223 Bretigny-sur-Orge Cedex, France. e.tiollier@... Secretory immunoglobulin A (sIgA) is the major immunoglobulin of the mucosal immune system. Whereas the suppressive effect of heavy training on mucosal immunity is well documented, little is known regarding the influence of hypoxia exposure on sIgA during altitude training. This investigation examined the impact of an 18-day Living high-training low (LHTL) training camp on sIgA levels in 11 (six females and five males) elite cross-country skiers. Subjects from the control group (n=5) trained and lived at 1,200 m of altitude, whereas, subjects from the LHTL group (n=6) trained at 1,200 m, but lived at a simulated altitude of 2,500, 3,000 and 3,500 m (3x6-day, 11 h day(-1)) in hypoxic rooms. Saliva samples were collected before, after each 6-day phases and 2 weeks thereafter (POST). Salivary sIgA, protein and cortisol were measured. There was a downward trend in sIgA concentrations over the study, which reached significance in LHTL (P<0.01), but not in control (P=0.08). Salivary IgA concentrations were still lower baseline at POST (P<0.05). Protein concentration increased in LHTL (P<0.05) and was negatively correlated with sIgA concentration after the 3,000 and 3,500 m-phase and at POST (P<0.05 all). Cortisol concentrations were unchanged over the study and no relationship was found between cortisol and sIgA. In summary, data were strongly suggestive of a cumulative negative effect of physical exercise and hypoxia on sIgA levels during LHTL training. Two weeks of active recovery did not allow for proper sIgA recovery. The mechanism underlying this depression of sIgA could be mediated by neural factors. " PMID: 15765238 Rodney. > > " The exercise-induced enhancement of influenza immunity is mediated > > in part by improvements in psychosocial factors in older adults. > > > > Kohut ML, Lee W, A, Arnston B, DW, Ekkekakis P, Yoon > > KJ, Bishop A, Cunnick JE. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 14, 2005 Report Share Posted August 14, 2005 And another: " ....................... The findings from some, but not all, studies support the possibility that exercise may attenuate immunosenescence. .............. Taken together, the accumulated data suggest that exercise may be an efficacious therapy for restoring immune function in the elderly. In general, long term exercise interventions appear to show the most promise. Exercise related improvements have been reported with respect to antibody titre, T cell function, macrophage response, alterations of the T(H) 1/T(H)2 cytokine balance, the level of pro-inflammatory cytokines, and changes in naive/memory cell ratio. However, current data is minimal ............... " PMID: 15633584 Rodney. --- In , " Rodney " <perspect1111@y...> wrote: > And another. In particular note: " Whereas the suppressive effect > of heavy training on mucosal immunity is well documented ....... " Quote Link to comment Share on other sites More sharing options...
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