Re: Antioxidants do not explain longevity in naked mole rat

[Guest guest]

Hi folks:

Does anyone know of any studies investigating the longevity of clean

shaven and bald men, compared with those with beards? ;; ^ )))

Rodney.

--- In , T <pct35768@y...>

wrote:

> I think you should think twice about downing megadoses of your

favorite pill-based antioxidant, because animals don't necessarily

need to resort to manipulating this variable to attain a longer

life. Maybe these reseachers didn't know how to " get to " the

right " oxidant " variable to see if this was contributing, but, I

think at the very least this research highlights the importance

of " intrinsic rigor " to organisms that can surmount frilly oxidative

considerations.

>

> =-=-=-=-=-=-=--==-=-=-

>

> http://www.sciencedirect.com/science/journal/00476374

>

> Antioxidants do not explain the disparate longevity between mice

and the longest-living rodent, the naked mole-rat

> Blazej Andziaka, b, P. O'Connorc and Rochelle Buffensteina,

b, ,

>

> aDepartment of Biology, City College of New York, 138th St. and

Convent Avenue, New York, NY 10031, USA

> bGraduate Center of the City University of New York, 365 5th

Avenue, New York, NY 10016, USA

> cDepartment of Genetic Medicine, Weill Cornell Medical College, 515

East 71st St., New York, NY 10021, USA

>

> Received 3 May 2005; revised 21 June 2005; accepted 28 June

2005. Available online 8 August 2005.

>

>

>

> Abstract

> The maximum lifespan of naked mole-rats (NMRs; Heterocephalus

glaber) is greater than that of any other rodent. These

hystricognaths survive in captivity >28 years, eight-times longer

than similar-sized mice. The present study tested if NMRs possess

superior antioxidant defenses compared to mice and if age-related

interspecies changes in antioxidants were evident. Activities of

Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and

cellular glutathione peroxidase (cGPx) were measured in livers of

physiologically equivalent age-matched NMRs (30, 75 and 130 months)

and CB6F1 mice (4, 12 and 18 months). In mice, Mn SOD activity

increased with age, while the activity of catalase and cGPx declined.

None of the antioxidants changed with age in mole-rats. cGPx activity

of NMRs was 70-times lower (p < 0.0001) than in mice, and resembled

that of cGPx knock-out animals. NMRs may partially compensate for the

lower cGPx when compared to mice, by having moderately higher

activities of the

> other antioxidants. It is nonetheless unlikely that antioxidant

defenses are responsible for the eight-fold longevity difference

between these two species. Maintenance of constant antioxidant

defenses with age in NMRs concurs with previous physiological data,

suggesting delayed aging in this species.

> Keywords: Antioxidants; Longevity; Mice; Naked mole-rats

>

>

>

> =-=-=-=-=-=--=-=-=--=--=-=--=-=

>

> T. pct35768@y...

>

>

> ---------------------------------

>

> Stay connected, organized, and protected. Take the tour

[Guest guest]

Hi folks:

Does anyone know of any studies investigating the longevity of clean

shaven and bald men, compared with those with beards? ;; ^ )))

Rodney.

--- In , T <pct35768@y...>

wrote:

> I think you should think twice about downing megadoses of your

favorite pill-based antioxidant, because animals don't necessarily

need to resort to manipulating this variable to attain a longer

life. Maybe these reseachers didn't know how to " get to " the

right " oxidant " variable to see if this was contributing, but, I

think at the very least this research highlights the importance

of " intrinsic rigor " to organisms that can surmount frilly oxidative

considerations.

>

> =-=-=-=-=-=-=--==-=-=-

>

> http://www.sciencedirect.com/science/journal/00476374

>

> Antioxidants do not explain the disparate longevity between mice

and the longest-living rodent, the naked mole-rat

> Blazej Andziaka, b, P. O'Connorc and Rochelle Buffensteina,

b, ,

>

> aDepartment of Biology, City College of New York, 138th St. and

Convent Avenue, New York, NY 10031, USA

> bGraduate Center of the City University of New York, 365 5th

Avenue, New York, NY 10016, USA

> cDepartment of Genetic Medicine, Weill Cornell Medical College, 515

East 71st St., New York, NY 10021, USA

>

> Received 3 May 2005; revised 21 June 2005; accepted 28 June

2005. Available online 8 August 2005.

>

>

>

> Abstract

> The maximum lifespan of naked mole-rats (NMRs; Heterocephalus

glaber) is greater than that of any other rodent. These

hystricognaths survive in captivity >28 years, eight-times longer

than similar-sized mice. The present study tested if NMRs possess

superior antioxidant defenses compared to mice and if age-related

interspecies changes in antioxidants were evident. Activities of

Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and

cellular glutathione peroxidase (cGPx) were measured in livers of

physiologically equivalent age-matched NMRs (30, 75 and 130 months)

and CB6F1 mice (4, 12 and 18 months). In mice, Mn SOD activity

increased with age, while the activity of catalase and cGPx declined.

None of the antioxidants changed with age in mole-rats. cGPx activity

of NMRs was 70-times lower (p < 0.0001) than in mice, and resembled

that of cGPx knock-out animals. NMRs may partially compensate for the

lower cGPx when compared to mice, by having moderately higher

activities of the

> other antioxidants. It is nonetheless unlikely that antioxidant

defenses are responsible for the eight-fold longevity difference

between these two species. Maintenance of constant antioxidant

defenses with age in NMRs concurs with previous physiological data,

suggesting delayed aging in this species.

> Keywords: Antioxidants; Longevity; Mice; Naked mole-rats

>

>

>

> =-=-=-=-=-=--=-=-=--=--=-=--=-=

>

> T. pct35768@y...

>

>

> ---------------------------------

>

> Stay connected, organized, and protected. Take the tour

[Guest guest]

Rodney, et al,

Perhaps the longevity comes from the stress of being cold...? You

should stop wearing clothes! ;-)

> > I think you should think twice about downing megadoses of your

> favorite pill-based antioxidant, because animals don't necessarily

> need to resort to manipulating this variable to attain a longer

> life. Maybe these reseachers didn't know how to " get to " the

> right " oxidant " variable to see if this was contributing, but, I

> think at the very least this research highlights the importance

> of " intrinsic rigor " to organisms that can surmount frilly

oxidative

> considerations.

> >

> > =-=-=-=-=-=-=--==-=-=-

> >

> > http://www.sciencedirect.com/science/journal/00476374

> >

> > Antioxidants do not explain the disparate longevity between mice

> and the longest-living rodent, the naked mole-rat

> > Blazej Andziaka, b, P. O'Connorc and Rochelle

Buffensteina,

> b, ,

> >

> > aDepartment of Biology, City College of New York, 138th St. and

> Convent Avenue, New York, NY 10031, USA

> > bGraduate Center of the City University of New York, 365 5th

> Avenue, New York, NY 10016, USA

> > cDepartment of Genetic Medicine, Weill Cornell Medical College,

515

> East 71st St., New York, NY 10021, USA

> >

> > Received 3 May 2005; revised 21 June 2005; accepted 28 June

> 2005. Available online 8 August 2005.

> >

> >

> >

> > Abstract

> > The maximum lifespan of naked mole-rats (NMRs; Heterocephalus

> glaber) is greater than that of any other rodent. These

> hystricognaths survive in captivity >28 years, eight-times longer

> than similar-sized mice. The present study tested if NMRs possess

> superior antioxidant defenses compared to mice and if age-related

> interspecies changes in antioxidants were evident. Activities of

> Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and

> cellular glutathione peroxidase (cGPx) were measured in livers of

> physiologically equivalent age-matched NMRs (30, 75 and 130 months)

> and CB6F1 mice (4, 12 and 18 months). In mice, Mn SOD activity

> increased with age, while the activity of catalase and cGPx

declined.

> None of the antioxidants changed with age in mole-rats. cGPx

activity

> of NMRs was 70-times lower (p < 0.0001) than in mice, and resembled

> that of cGPx knock-out animals. NMRs may partially compensate for

the

> lower cGPx when compared to mice, by having moderately higher

> activities of the

> > other antioxidants. It is nonetheless unlikely that antioxidant

> defenses are responsible for the eight-fold longevity difference

> between these two species. Maintenance of constant antioxidant

> defenses with age in NMRs concurs with previous physiological data,

> suggesting delayed aging in this species.

> > Keywords: Antioxidants; Longevity; Mice; Naked mole-rats

> >

> >

> >

> > =-=-=-=-=-=--=-=-=--=--=-=--=-=

> >

> > T. pct35768@y...

> >

> >

> > ---------------------------------

> >

> > Stay connected, organized, and protected. Take the tour

[Guest guest]

Rodney, et al,

Perhaps the longevity comes from the stress of being cold...? You

should stop wearing clothes! ;-)

> > I think you should think twice about downing megadoses of your

> favorite pill-based antioxidant, because animals don't necessarily

> need to resort to manipulating this variable to attain a longer

> life. Maybe these reseachers didn't know how to " get to " the

> right " oxidant " variable to see if this was contributing, but, I

> think at the very least this research highlights the importance

> of " intrinsic rigor " to organisms that can surmount frilly

oxidative

> considerations.

> >

> > =-=-=-=-=-=-=--==-=-=-

> >

> > http://www.sciencedirect.com/science/journal/00476374

> >

> > Antioxidants do not explain the disparate longevity between mice

> and the longest-living rodent, the naked mole-rat

> > Blazej Andziaka, b, P. O'Connorc and Rochelle

Buffensteina,

> b, ,

> >

> > aDepartment of Biology, City College of New York, 138th St. and

> Convent Avenue, New York, NY 10031, USA

> > bGraduate Center of the City University of New York, 365 5th

> Avenue, New York, NY 10016, USA

> > cDepartment of Genetic Medicine, Weill Cornell Medical College,

515

> East 71st St., New York, NY 10021, USA

> >

> > Received 3 May 2005; revised 21 June 2005; accepted 28 June

> 2005. Available online 8 August 2005.

> >

> >

> >

> > Abstract

> > The maximum lifespan of naked mole-rats (NMRs; Heterocephalus

> glaber) is greater than that of any other rodent. These

> hystricognaths survive in captivity >28 years, eight-times longer

> than similar-sized mice. The present study tested if NMRs possess

> superior antioxidant defenses compared to mice and if age-related

> interspecies changes in antioxidants were evident. Activities of

> Cu/Zn superoxide dismutase (Cu/Zn, SOD), Mn SOD, catalase and

> cellular glutathione peroxidase (cGPx) were measured in livers of

> physiologically equivalent age-matched NMRs (30, 75 and 130 months)

> and CB6F1 mice (4, 12 and 18 months). In mice, Mn SOD activity

> increased with age, while the activity of catalase and cGPx

declined.

> None of the antioxidants changed with age in mole-rats. cGPx

activity

> of NMRs was 70-times lower (p < 0.0001) than in mice, and resembled

> that of cGPx knock-out animals. NMRs may partially compensate for

the

> lower cGPx when compared to mice, by having moderately higher

> activities of the

> > other antioxidants. It is nonetheless unlikely that antioxidant

> defenses are responsible for the eight-fold longevity difference

> between these two species. Maintenance of constant antioxidant

> defenses with age in NMRs concurs with previous physiological data,

> suggesting delayed aging in this species.

> > Keywords: Antioxidants; Longevity; Mice; Naked mole-rats

> >

> >

> >

> > =-=-=-=-=-=--=-=-=--=--=-=--=-=

> >

> > T. pct35768@y...

> >

> >

> > ---------------------------------

> >

> > Stay connected, organized, and protected. Take the tour