CR selective toxicologic and carcinogenic effects

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Hi All,

It seems from the not pdf-available below paper that " survival, body weights,

body

fat, fat-related serum chemistry parameters, and incidences of heart, kidney and

liver microscopic changes " were selectively affected by CR among the

t " oxicologic

and carcinogenic effects of DAG (diacylglycerol) oil " .

Food Chem Toxicol. 2005 Aug 3; [Epub ahead of print] Related Articles, Links

A 24-month dietary carcinogenicity study of DAG (diacylglycerol) in rats.

Chengelis CP, Kirkpatrick JB, Bruner RH, Freshwater L, Morita O, Tamaki Y,

Suzuki H.

Toxicologic and carcinogenic effects of DAG (diacylglycerol) oil, administered

in

diet for 24 months to Crl:CD(®)(SD)-IGS BR rats, were evaluated using

diet-restricted and ad libitum-fed groups. All dietary fat (consistently 5.5%)

was

provided by DAG and/or the control article, TG (triacylglycerol) oil. Dietary

concentrations (% DAG/% TG) were 0%/5.5%, 1%/4.5%, 2.75%/2.75% and 5.5%/0%.

Separate

groups were fed the 0%/5.5% and 5.5%/0% diets ad libitum. Another group received

the

standard rodent diet (fat content 4.5%) on the restricted feeding regimen.

Clinical

condition, ophthalmic findings, palpable mass occurrence, body composition,

clinical

pathology parameters and incidence of neoplastic lesions were unaffected by DAG

in

comparison to TG. Groups fed the 5.5% (DAG and/or TG) fat diet when compared to

the

4.5% fat diet group displayed lower survival, higher body weights, organ

weights,

percent body fat, higher fat-related serum chemistry parameters, incidence of

microscopic changes in the heart, kidneys, liver, bone marrow, spleen, and

incidences of pituitary and mammary gland neoplasms. Parameters more affected in

all

the ad libitum groups than in the restricted diet groups (regardless of test

article) fed the same diet included survival, body weights, body fat,

fat-related

serum chemistry parameters, and incidences of heart, kidney and liver

microscopic

changes. However, the DAG and TG ad libitum-fed groups were not different from

one

another. Thus, DAG-treated animals had no higher risk of carcinogenic effects

than

rats fed on similar feeding regimens with a diet in which all dietary fat came

from

TG. PMID: 16084639

Al Pater, PhD; email: old542000@...

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