>5 caffeinated drinks a day = hemorrhagic stroke?

[Guest guest]

I honestly think that the effect they are describing is associated with an acute exacerbation of "prehypertension" seen in young, adult "freely eating" population consuming large amounts of caffeine.

However, there may be an "independent" effect of caffeine on the regulation of the cerebrovascular tone that may contribute to the observed association. Again, though, I think this effect may be strongest in the "normotensive" population.

In any case, it is kind of "spooky", I suppose, because the capacity of low BMI to increase the risk for this type of stroke is something that has been documented in prior research.

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Stroke. 2005 Aug 4; [Epub ahead of print]

Major Risk Factors for Intracerebral Hemorrhage in the Young Are Modifiable.Feldmann E, Broderick JP, Kernan WN, Viscoli CM, Brass LM, Brott T, Morgenstern LB, Wilterdink JL, Horwitz RI.From the Department of Clinical Neurosciences, Brown Medical School, Providence, RI; Department of Neurology, University of Cincinnati, Ohio; Departments of Internal Medicine, Neurology, and Epidemiology and Public Health, Yale University School of

Medicine, New Haven, Conn; Stroke Program, University of Michigan, Ann Arbor; Mayo Medical School, Rochester, Minn; and Case Western Reserve University School of Medicine, Cleveland, Ohio.BACKGROUND AND PURPOSE: To identify risk factors for intracerebral hemorrhage (ICH), we examined data from the Hemorrhagic Stroke Project (HSP), a case-control study of hemorrhagic stroke among men and women aged 18 to 49 years. METHODS: Case subjects for the HSP were recruited from 44 hospitals in the United States. Eligibility criteria included an ICH within 30 days preceding enrollment, no history of stroke or known brain lesion. For this report, we focused on patients with primary ICH, defined as not associated with an aneurysm, arteriovenous malformation or other structural lesion. Two control subjects were sought for each case subject. A multivariate regression analysis was performed to determine risk factors for primary ICH. RESULTS: A total of 1714 patients with hemorrhagic stroke

were identified for participation in the HSP. Of these, 217 cases met the criteria for primary ICH. Cases with primary ICH were matched to 419 controls. Independent risk factors for ICH included hypertension (adjusted odds ratio [OR], 5.71; 95% CI, 3.61 to 9.05), diabetes (adjusted OR, 2.40; 95% CI, 1.15 to 5.01), menopause (adjusted OR, 2.50; 95% CI, 1.06 to 5.88), current cigarette smoking (adjusted OR, 1.58; 95% CI, 1.02 to 2.44), alcoholic drinks>/=2/day (adjusted OR, 2.23; 95% CI, 1.16 to 4.32), caffeinated drinks>/=5/day (adjusted OR, 1.73; 95% CI, 1.08 to 2.79), and caffeine in drugs (adjusted OR, 3.55; 95% CI, 1.24 to 10.20). CONCLUSIONS: Among young men and women, the major risk factors for primary ICH can be modified, suggesting that this type of stroke may be preventable. Our findings for caffeine and menopause warrant further study.PMID: 16081867 [PubMed - as supplied by publisher]

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