Colon cancer and dairy ingredients

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Colon cancer and dairy ingredients

Hi All,

It seems from the pdf-available below that our level of dietary calcium,

phosphorus

and vitamin D, dairy products associates with a decreased risk of colorectal

adenoma

and cancer.

It was a prospective study.

See the below.

Kesse E, Boutron-Ruault MC, Norat T, Riboli E, Clavel-Chapelon F.

Dietary calcium, phosphorus, vitamin D, dairy products and the risk of

colorectal

adenoma and cancer among French women of the E3N-EPIC prospective study.

Int J Cancer. 2005 Oct 20;117(1):137-44.

PMID: 15880532

A protective effect of calcium and/or dairy products on colorectal cancer has

been reported in epidemiological studies but the findings are considered

inconsistent. In particular, it is unclear whether they act at a particular step

of

the adenoma-carcinoma sequence. To investigate the effect of dairy product

consumption and dietary calcium, vitamin D and phosphorus intake on the

adenoma-carcinoma sequence in the French E3N-EPIC prospective study. The

population

for the study of risk factors for adenomas was composed of 516 adenoma cases,

including 175 high-risk adenomas, and of 4,804 polyp-free subjects confirmed by

colonoscopy. The population for the colorectal cancer study was composed of 172

cases and 67,312 cancer-free subjects. Diet was assessed using a

self-administered

questionnaire completed at baseline. There was a trend of decreasing risk of

both

adenoma (p(trend)= 0.04) and cancer (p(trend)=0.08) with increasing calcium

intake,

with RRs for adenoma and cancer of 0.80 (IC 95%=0.62-1.03) and 0.72 (95%

CI=0.47-1.10), respectively, in the fourth quartile compared to the first. A

protective effect of dairy products on adenoma (RR(Q4 vs. Q1)= 0.80, 95%

CI=0.62-1.05, p(trend)= 0.04) was observed and of milk consumption on colorectal

cancer (RR(Q4vs. Q1)= 0.54, 95% CI=0.33-0.89, p(trend)= 0.09), although the

latter

did not reach significance. Phosphorus intake also decreased the risk of adenoma

(RR(Q4 vs. Q1)=0.70, 95% CI=0.54-0.90, p(trend)= 0.005). No vitamin D effect was

identified. Our data support the hypothesis that calcium, dairy products and

phosphorus exert a protective effect at certain steps of the adenoma-carcinoma

sequence.

.... Characteristics of the studied populations

The median follow-up time was 3.7 years in the adenoma study and 6.9 years in

the

cancer study. ...

Al Pater, PhD; email: old542000@...

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