Re: Leanness vs. CR for longevity

[Guest guest]

Thanks, Alan,

Let me understand, I don't know any who want to carry excess fat, but this article says the centi's have characteristic insulin sensitivity, as opposed to the obese's insulin resistance. That IR fat is hard to get off. Or let's say the fat in those IR cells.

Maybe Dr. Taller's high fat idea? But does it stay off?

Regards.

[ ] Leanness vs. CR for longevity

Hi All,See the not pdf-available below paper that may have us believe that the reducedamount of fat tissue that we have could be the reason for the benefit to diseaseavoidance. Knowledgeable CRers seem to hold contrary views.Kloting N, Bluher M.Extended longevity and insulin signaling in adipose tissue.Exp Gerontol. 2005 Aug 24; [Epub ahead of print] PMID: 16125891Caloric restriction and leanness have been shown to increase longevity in organismsranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in theaging process and in determination of lifespan. We have recently shown thatfat-specific disruption of the insulin receptor gene is sufficient to increaselifespan in FIRKO mice, suggesting that reduced adiposity, even in the presence ofnormal or increased food intake, can extend lifespan. The model also suggests aspecial role for the insulin-signaling pathway in adipose tissue in the longevityprocess. Reduced fat mass has an impact on the duration of life in several othermodel organisms. In Drosophila, a specific reduction in the fat body throughoverexpression of forkhead type transcription factor (dFOXO) extends lifespan.Furthermore, sirtuin1 (SIRT1), the mammalian ortholog of the life-extending yeastgene silent information regulator 2 (SIR2), was proposed to be involved in themolecular mechanisms linking lifespan to adipose tissue. In the control of humanaging and longevity, one of the striking physiological characteristics identified incentenarians is their greatly increased insulin sensitivity even compared withyounger individuals. The effect of reduced adipose tissue mass on lifespan could bedue to the prevention of obesity-related metabolic disorders including type 2diabetes and atherosclerosis.Al Pater, PhD; email: old542000@...

[Guest guest]

Thanks, Alan,

Let me understand, I don't know any who want to carry excess fat, but this article says the centi's have characteristic insulin sensitivity, as opposed to the obese's insulin resistance. That IR fat is hard to get off. Or let's say the fat in those IR cells.

Maybe Dr. Taller's high fat idea? But does it stay off?

Regards.

[ ] Leanness vs. CR for longevity

Hi All,See the not pdf-available below paper that may have us believe that the reducedamount of fat tissue that we have could be the reason for the benefit to diseaseavoidance. Knowledgeable CRers seem to hold contrary views.Kloting N, Bluher M.Extended longevity and insulin signaling in adipose tissue.Exp Gerontol. 2005 Aug 24; [Epub ahead of print] PMID: 16125891Caloric restriction and leanness have been shown to increase longevity in organismsranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in theaging process and in determination of lifespan. We have recently shown thatfat-specific disruption of the insulin receptor gene is sufficient to increaselifespan in FIRKO mice, suggesting that reduced adiposity, even in the presence ofnormal or increased food intake, can extend lifespan. The model also suggests aspecial role for the insulin-signaling pathway in adipose tissue in the longevityprocess. Reduced fat mass has an impact on the duration of life in several othermodel organisms. In Drosophila, a specific reduction in the fat body throughoverexpression of forkhead type transcription factor (dFOXO) extends lifespan.Furthermore, sirtuin1 (SIRT1), the mammalian ortholog of the life-extending yeastgene silent information regulator 2 (SIR2), was proposed to be involved in themolecular mechanisms linking lifespan to adipose tissue. In the control of humanaging and longevity, one of the striking physiological characteristics identified incentenarians is their greatly increased insulin sensitivity even compared withyounger individuals. The effect of reduced adipose tissue mass on lifespan could bedue to the prevention of obesity-related metabolic disorders including type 2diabetes and atherosclerosis.Al Pater, PhD; email: old542000@...