Guest guest Posted October 4, 2005 Report Share Posted October 4, 2005 Hi All, I thought that you might enjoy to see the below supporting moderating of CR is better. Yossi Dagon, Yosefa Avraham, Iddo Magen, Arie Gertler, Tamir Ben-Hur, and Elliot M. Berry Nutritional status, cognition and survival-a new role for leptin and AMPK JBC published October 3, 2005 as doi:10.1074/jbc.M507607200 http://www.jbc.org/cgi/reprint/M507607200v1 While adequate nutrition is essential for optimal neural activity and survival, mild energy restriction may improve cognition and prolong longevity. Energy status is monitored by cellular AMP-activated protein kinase (AMPK) system, while leptin regulates total energy balance. We investigated the roles of AMPK and leptin in cognition and survival under diet restriction (DR). Hippocampal AMPK activity increases with energy restriction. Modest activation (DR to 60%) induces neurogenesis and improves cognition. However, DR to 40% augmented AMPK activity, reduced cognition, catecholamines and increased neural apoptosis and mortality. Leptin signaling is preserved only in DR to 60%, countering the effects of AMPK “over-activation” by preventing neuro-apoptosis, restoring noradrenergic activity and behavioral performance and increasing longevity. The balance between leptin and AMPK is crucial in determining neuronal fate, cognitive ability and survival. Should these findings extend to Man, then controlled activation of AMPK may improve neurodegenerative diseases, and leptin may have a new role in treating stress associated malnutrition. Al Pater, PhD; email: old542000@... __________________________________ - PC Magazine Editors' Choice 2005 http://mail. Quote Link to comment Share on other sites More sharing options...
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