Re: Stomach and throat cancer, meat iron and folate

September 19, 2005

Hi Al:

Thanks for that study. Very interesting. And another good reason to

avoid excess iron while making sure one gets enough zinc.

Is there any way we can find out how much zinc those in the highest

quintile of zinc intake were consuming? Too much zinc can also be a

problem I seem to remember. But I don't remember why, or how much is

too much.

Rodney.

--- In , Al Pater <old542000@y...>

wrote:

> Hi All,

>

> The pdf-available below paper finds that intakes of the the heme

iron that is found

> in meat associate with more stomach and throat cancer and folate

intake is

> significantly associated with fewer of these cancers.

>

> Lee DH, KE, Folsom AR, s DR Jr.

> Heme iron, zinc and upper digestive tract cancer: The Iowa Women's

Health Study.

> Int J Cancer. 2005 May 31;117(4):643-647 [Epub ahead of print]

> PMID: 15929082

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15929082 & query_hl=7

>

> ... 34,708 postmenopausal women, aged 55-69 years at baseline who

completed a food

> frequency questionnaire, were followed 16 years. There were 75

upper digestive tract

> cancer cases (52 gastric cancer and 23 esophageal cancer). When

heme iron and zinc

> were mutually adjusted, in dose-response manners, heme iron intake

was positively

> associated with the risk of upper digestive tract cancer, while

zinc intake was

> inversely associated with risk. After adjusting for age, total

energy intake,

> cigarette smoking and alcohol consumption, relative risks for

quintiles of heme iron

> intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and

corresponding

> relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13

(p for trend <

> 0.01). Additional adjustment for body mass index, physical

activity, hormone

> replacement therapy, multivitamin intake and intake of saturated

fat, vitamin C,

> vitamin E and folate did not change the results. ...

>

> Al Pater, PhD; email: old542000@y...

>

> __________________________________

> - PC Magazine Editors' Choice 2005

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September 19, 2005