Stomach and throat cancer, meat iron and folate

[Guest guest]

Hi All,

The pdf-available below paper finds that intakes of the the heme iron that is

found

in meat associate with more stomach and throat cancer and folate intake is

significantly associated with fewer of these cancers.

Lee DH, KE, Folsom AR, s DR Jr.

Heme iron, zinc and upper digestive tract cancer: The Iowa Women's Health Study.

Int J Cancer. 2005 May 31;117(4):643-647 [Epub ahead of print]

PMID: 15929082

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15929082 & query_hl=7

.... 34,708 postmenopausal women, aged 55-69 years at baseline who completed a

food

frequency questionnaire, were followed 16 years. There were 75 upper digestive

tract

cancer cases (52 gastric cancer and 23 esophageal cancer). When heme iron and

zinc

were mutually adjusted, in dose-response manners, heme iron intake was

positively

associated with the risk of upper digestive tract cancer, while zinc intake was

inversely associated with risk. After adjusting for age, total energy intake,

cigarette smoking and alcohol consumption, relative risks for quintiles of heme

iron

intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and

corresponding

relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p for trend

<

0.01). Additional adjustment for body mass index, physical activity, hormone

replacement therapy, multivitamin intake and intake of saturated fat, vitamin C,

vitamin E and folate did not change the results. ...

Al Pater, PhD; email: old542000@...

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