] Re: Stomach and throat cancer, meat iron and folate

[Guest guest]

Hi folks:

These data Al has provided are unbelievably interesting - naturally,

as always, assuming the study results are correct and get confirmed.

Here is the study abstract:

-----------------

" Heme iron, zinc and upper digestive tract cancer: The Iowa Women's

Health Study.

Lee DH, KE, Folsom AR, s DR Jr.

Department of Preventive Medicine, College of Medicine, Kyungpook

National University, Daegu, Korea.

We examined associations among dietary heme iron as a possible pro-

oxidant, dietary zinc as a possible antioxidant, and the incidence of

upper digestive tract cancer; 34,708 postmenopausal women, aged 55-69

years at baseline who completed a food frequency questionnaire, were

followed 16 years. There were 75 upper digestive tract cancer cases

(52 gastric cancer and 23 esophageal cancer). When heme iron and zinc

were mutually adjusted, in dose-response manners, heme iron intake

was positively associated with the risk of upper digestive tract

cancer, while zinc intake was inversely associated with risk. After

adjusting for age, total energy intake, cigarette smoking and alcohol

consumption, relative risks for quintiles of heme iron intake were

1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and corresponding

relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p

for trend < 0.01). Additional adjustment for body mass index,

physical activity, hormone replacement therapy, multivitamin intake

and intake of saturated fat, vitamin C, vitamin E and folate did not

change the results. Higher intake of heme iron is associated with

higher risk, while higher intake of zinc is associated with lower,

risk of upper digestive tract cancer. "

----------------

Now the reason the data are interesting, imo, is that the zinc intake

of the people consuming the most is not especially high. Just 18.6

mg per day. Yet the people at the low end, consuming 6.5 mg per day,

appear, according to the study, to have their chances of getting

upper gastro-intestinal tract cancer increased by an absolutely HUGE

7.7 times!!!

They only checked for this type of cancer. It may be that there are

similar effects for other types of cancer also.

So the key message here seems to be that even a relatively modest

zinc deficiency is a major cancer risk. Do we all know where our

zinc intakes are this evening?

Rodney.

> > Hi All,

> >

> > The pdf-available below paper finds that intakes of the the heme

> iron that is found

> > in meat associate with more stomach and throat cancer and folate

> intake is

> > significantly associated with fewer of these cancers.

> >

> > Lee DH, KE, Folsom AR, s DR Jr.

> > Heme iron, zinc and upper digestive tract cancer: The Iowa

Women's

> Health Study.

> > Int J Cancer. 2005 May 31;117(4):643-647 [Epub ahead of print]

> > PMID: 15929082

>

> Al Pater, PhD; email: old542000@y...

>

> __________________________________________________

>

[Guest guest]

My MV is 17mg Zn, but I add a 50mg pill when throat is irritated - short periods.

Also do Ca/Mg/Zn when I think I need Ca.

Zn helps with colds.

Regards.

[ ] ] Re: Stomach and throat cancer, meat iron and folate

Hi folks:These data Al has provided are unbelievably interesting - naturally, as always, assuming the study results are correct and get confirmed.Here is the study abstract:-----------------"Heme iron, zinc and upper digestive tract cancer: The Iowa Women's Health Study.Lee DH, KE, Folsom AR, s DR Jr.Department of Preventive Medicine, College of Medicine, Kyungpook National University, Daegu, Korea.We examined associations among dietary heme iron as a possible pro-oxidant, dietary zinc as a possible antioxidant, and the incidence of upper digestive tract cancer; 34,708 postmenopausal women, aged 55-69 years at baseline who completed a food frequency questionnaire, were followed 16 years. There were 75 upper digestive tract cancer cases (52 gastric cancer and 23 esophageal cancer). When heme iron and zinc were mutually adjusted, in dose-response manners, heme iron intake was positively associated with the risk of upper digestive tract cancer, while zinc intake was inversely associated with risk. After adjusting for age, total energy intake, cigarette smoking and alcohol consumption, relative risks for quintiles of heme iron intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and corresponding relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p for trend < 0.01). Additional adjustment for body mass index, physical activity, hormone replacement therapy, multivitamin intake and intake of saturated fat, vitamin C, vitamin E and folate did not change the results. Higher intake of heme iron is associated with higher risk, while higher intake of zinc is associated with lower, risk of upper digestive tract cancer."----------------Now the reason the data are interesting, imo, is that the zinc intake of the people consuming the most is not especially high. Just 18.6 mg per day. Yet the people at the low end, consuming 6.5 mg per day, appear, according to the study, to have their chances of getting upper gastro-intestinal tract cancer increased by an absolutely HUGE 7.7 times!!!They only checked for this type of cancer. It may be that there are similar effects for other types of cancer also.So the key message here seems to be that even a relatively modest zinc deficiency is a major cancer risk. Do we all know where our zinc intakes are this evening?Rodney.> > Hi All,> > > > The pdf-available below paper finds that intakes of the the heme > iron that is found> > in meat associate with more stomach and throat cancer and folate > intake is> > significantly associated with fewer of these cancers.> > > > Lee DH, KE, Folsom AR, s DR Jr.> > Heme iron, zinc and upper digestive tract cancer: The Iowa Women's > Health Study.> > Int J Cancer. 2005 May 31;117(4):643-647 [Epub ahead of print] > > PMID: 15929082> > Al Pater, PhD; email: old542000@y...> > __________________________________________________>

[Guest guest]

My MV is 17mg Zn, but I add a 50mg pill when throat is irritated - short periods.

Also do Ca/Mg/Zn when I think I need Ca.

Zn helps with colds.

Regards.

[ ] ] Re: Stomach and throat cancer, meat iron and folate

Hi folks:These data Al has provided are unbelievably interesting - naturally, as always, assuming the study results are correct and get confirmed.Here is the study abstract:-----------------"Heme iron, zinc and upper digestive tract cancer: The Iowa Women's Health Study.Lee DH, KE, Folsom AR, s DR Jr.Department of Preventive Medicine, College of Medicine, Kyungpook National University, Daegu, Korea.We examined associations among dietary heme iron as a possible pro-oxidant, dietary zinc as a possible antioxidant, and the incidence of upper digestive tract cancer; 34,708 postmenopausal women, aged 55-69 years at baseline who completed a food frequency questionnaire, were followed 16 years. There were 75 upper digestive tract cancer cases (52 gastric cancer and 23 esophageal cancer). When heme iron and zinc were mutually adjusted, in dose-response manners, heme iron intake was positively associated with the risk of upper digestive tract cancer, while zinc intake was inversely associated with risk. After adjusting for age, total energy intake, cigarette smoking and alcohol consumption, relative risks for quintiles of heme iron intake were 1.0, 1.53, 2.15, 3.05 and 2.83 (p for trend = 0.06) and corresponding relative risks for zinc intake were 1.0, 0.86, 0.42, 0.37 and 0.13 (p for trend < 0.01). Additional adjustment for body mass index, physical activity, hormone replacement therapy, multivitamin intake and intake of saturated fat, vitamin C, vitamin E and folate did not change the results. Higher intake of heme iron is associated with higher risk, while higher intake of zinc is associated with lower, risk of upper digestive tract cancer."----------------Now the reason the data are interesting, imo, is that the zinc intake of the people consuming the most is not especially high. Just 18.6 mg per day. Yet the people at the low end, consuming 6.5 mg per day, appear, according to the study, to have their chances of getting upper gastro-intestinal tract cancer increased by an absolutely HUGE 7.7 times!!!They only checked for this type of cancer. It may be that there are similar effects for other types of cancer also.So the key message here seems to be that even a relatively modest zinc deficiency is a major cancer risk. Do we all know where our zinc intakes are this evening?Rodney.> > Hi All,> > > > The pdf-available below paper finds that intakes of the the heme > iron that is found> > in meat associate with more stomach and throat cancer and folate > intake is> > significantly associated with fewer of these cancers.> > > > Lee DH, KE, Folsom AR, s DR Jr.> > Heme iron, zinc and upper digestive tract cancer: The Iowa Women's > Health Study.> > Int J Cancer. 2005 May 31;117(4):643-647 [Epub ahead of print] > > PMID: 15929082> > Al Pater, PhD; email: old542000@y...> > __________________________________________________>