Re: MonoAmine Oxidase (MAO) inhibition as adjudct to CR? (Selegeline/Deprenyl)

[Guest guest]

Ya, taken very low dose for many years. Never noticed any effect, acutely. What dose do you consider low?

Thanks!

On 11/22/05, d7882001 <d7882001@...> wrote:

Has anyone tried Selegeline (also known as L-Deprenyl) in addtion toCR? While I am leary of medication use, I find that it helps decrease

appetite a bit, and improves cognitive function if only mildy used(low BMI, low dose).The ref & links below indicate research involving it's lifespanenhancing effects, althought not as dramatic as CR..

(I have to check if there is something on how long a Wistar-Logan ratlives on a CR diet...)<snippet>DEPRENYL: THE ANTI-AGING DRUG4 series of rat experiments, as well as an experiment with beagle

dogs, have shown that DPR can extend lifespan significantly, evenbeyond the " technical lifespan " of a species. Knoll reported that 132Wistar-Logan rats were treated from the end of their second year of

life with either saline injections or 0.25 mg/kg DPR injection 3 timesweekly until death. (11)In the saline-treated group the oldest rat reached 164 weeks of age,and the average lifespan of the group was 147 weeks. In the DPR group,

the average lifespan was 192 weeks, with the shortest-living rat dyingat 171 weeks, and the longest-lived rat reaching 226 weeks.<snippet>http://www.worldhealth.net/p/1008,2045.html

" The dogs were given the equivalent of 77 mg/day for a 170-poundperson. 80% of the deprenyl dogs survived to the end of theexperiment, whereas only 39% of the placebo dogs survived [*6]. "

http://www.benbest.com/lifeext/deprenyl.htmlhis refs:[*1] " Longevity Study with (-)Deprenyl " ph KnollMECHANISMS OF AGING AND DEVELOPMENT 46:237-262 (1988)

[*2] " Maintenance on L-Deprenyl Prolongs Life in AgedMale Rats " Milgram, et.al.LIFE SCIENCES 47:415-420 (1990)[*3] " Chronic Treatment of (-)Deprenyl Prolongs the Life

Span of Male Fischer 344 Rats " K.Kitani, et.al.LIFE SCIENCES 52:281-288 (1992)[*4] " Sexually Low Performing Male Rats Die Earlier Than Their HighPerforming Peers and (-)Deprenyl Treatment Eliminates This

Difference " ph KnollLIFE SCIENCES 54:1047-1057 (1994)[*5] " Chronic Treatment of Syrian Hamsters with Low-Dose SelegilineIncreases Life Span in Females But Not Males " S.Stoll,

et.al.NEUROBIOLOGY OF AGING 18:205-211 (1997)[*6] " Treatment with L-Deprenyl Prolongs Life in Elderly Dogs " W.W. Ruehl, et.al.LIFE SCIENCES 61:1037-1044 (1997)

[*7] " Age-Related Memory Decline and Longevity under Treatmentwith Selegiline " S.Stoll, et.al.LIFE SCIENCES 25/26:2155-2163 (1994)

[Guest guest]

Ya, taken very low dose for many years. Never noticed any effect, acutely. What dose do you consider low?

Thanks!

On 11/22/05, d7882001 <d7882001@...> wrote:

Has anyone tried Selegeline (also known as L-Deprenyl) in addtion toCR? While I am leary of medication use, I find that it helps decrease

appetite a bit, and improves cognitive function if only mildy used(low BMI, low dose).The ref & links below indicate research involving it's lifespanenhancing effects, althought not as dramatic as CR..

(I have to check if there is something on how long a Wistar-Logan ratlives on a CR diet...)<snippet>DEPRENYL: THE ANTI-AGING DRUG4 series of rat experiments, as well as an experiment with beagle

dogs, have shown that DPR can extend lifespan significantly, evenbeyond the " technical lifespan " of a species. Knoll reported that 132Wistar-Logan rats were treated from the end of their second year of

life with either saline injections or 0.25 mg/kg DPR injection 3 timesweekly until death. (11)In the saline-treated group the oldest rat reached 164 weeks of age,and the average lifespan of the group was 147 weeks. In the DPR group,

the average lifespan was 192 weeks, with the shortest-living rat dyingat 171 weeks, and the longest-lived rat reaching 226 weeks.<snippet>http://www.worldhealth.net/p/1008,2045.html

" The dogs were given the equivalent of 77 mg/day for a 170-poundperson. 80% of the deprenyl dogs survived to the end of theexperiment, whereas only 39% of the placebo dogs survived [*6]. "

http://www.benbest.com/lifeext/deprenyl.htmlhis refs:[*1] " Longevity Study with (-)Deprenyl " ph KnollMECHANISMS OF AGING AND DEVELOPMENT 46:237-262 (1988)

[*2] " Maintenance on L-Deprenyl Prolongs Life in AgedMale Rats " Milgram, et.al.LIFE SCIENCES 47:415-420 (1990)[*3] " Chronic Treatment of (-)Deprenyl Prolongs the Life

Span of Male Fischer 344 Rats " K.Kitani, et.al.LIFE SCIENCES 52:281-288 (1992)[*4] " Sexually Low Performing Male Rats Die Earlier Than Their HighPerforming Peers and (-)Deprenyl Treatment Eliminates This

Difference " ph KnollLIFE SCIENCES 54:1047-1057 (1994)[*5] " Chronic Treatment of Syrian Hamsters with Low-Dose SelegilineIncreases Life Span in Females But Not Males " S.Stoll,

et.al.NEUROBIOLOGY OF AGING 18:205-211 (1997)[*6] " Treatment with L-Deprenyl Prolongs Life in Elderly Dogs " W.W. Ruehl, et.al.LIFE SCIENCES 61:1037-1044 (1997)

[*7] " Age-Related Memory Decline and Longevity under Treatmentwith Selegiline " S.Stoll, et.al.LIFE SCIENCES 25/26:2155-2163 (1994)