Diet + blood fats for fish vs. olive oil

[Guest guest]

Hi All,

The below paper was a study of how fish versus olive oil may affect multiple

sclerosis pathology. However, the effect on the levels of blood lipids may be

more

in our interest.

See the below pdf-available paper excerpts. That different fat levels were used

in

the diets may be a complication.

" 1.visit " and " last visit " in Table 2 seem to represent the first revisit at

week 1

and the last visit at an average of 11 months.

Weinstock-Guttman B, Baier M, Park Y, Feichter J, Lee-Kwen P, Gallagher E,

Venkatraman J, Meksawan K, Deinehert S, Pendergast D, Awad AB, Ramanathan M,

Munschauer F, Rudick R.

Low fat dietary intervention with omega-3 fatty acid supplementation in multiple

sclerosis patients.

Prostaglandins Leukot Essent Fatty Acids. 2005 Nov;73(5):397-404.

PMID: 16099630

31 ... patients

.... This was a double-blind, randomized study to determine the effect of a low

fat

diet supplemented with fish oil (FO) vs. olive oil (OO)

.... After enrollment patients were randomly assigned to receive either the FO or

OO

supplementation. The FO group received 6 FO capsules per day containing 1 g FO

(65%

omega-3; EPA 1.98 g and DHA 1.32 g/day) (EPAX 5500 EE, Tishcon Corp.) as well as

the

recommendation for a very low fat diet intake. Total fat intake including the

omega-3 PUFA supplements had not to exceed 15% of the total daily calories

consumed.

The OO group received the American Heart Association Step I diet which is a

controlled low cholesterol diet (total fat not exceeding 30% of total daily

calories

and saturated fats <10%), with “placebo” capsules containing equivalent of olive

oil

supplements (6 capsules of 1 g OO/day). Patients knew the percentage of dietary

fat

but did not know the assignment of capsules oil supplementation. All patients

received 400 units of Vitamin E, one multivitamin tablet (not containing any

PUFA)

and at least 500 mg calcium per day. No additional supplements or changes in

symptomatic therapies were allowed during the study.

.... Serum fatty acid profiles ... Values were expressed as percentages of total

fatty acids.

.... Table 2. Change in serum lipids and fat intake

===============

Variable----FO OO----P-value

----Mean SD Mean SD----

===============

LDL at 1.visit 120.9 21.6 120.3 38.7 NS

LDL at last visit 125.1 25.9 148.5 93.6 NS

LDL change 4.2 23.1 25.0 93.3 NS

HDL at 1. visit 49.9 10.8 58.0 13.6 NS

HDL at last visit 50.6 10.3 47.1 17.0 NS

HDL change 1.8 7.6 -11.2 19.7 0.0318

Fat at 1. visit 19.6 12.9 21.8 8.5 NS

Fat at last visit 19.0 8.1 25.7 7.6 0.0384

Fat change -0.6 13.9 3.9 8.5 NS

Calories at 1.visit 1470 437.7 1765 855.8 NS

Calories at last visit 1467 720.7 1602 563.5 NS

Calories change -2.7 691.6 -162.2 553.1 NS

.... Table 3. Percent change in fatty acids (chromatography data)

===============

Lipid [FO=] 15% diet mean (SD) [OO=] 30% diet mean (SD) P-value

===============

18:1(9) OO -0.65 (5.47) -3.38 (8.94) 0.6664

20:5(3) EPA 0.36 (0.58) -0.20 (0.35) 0.0270

22:5(3) 0.39 (0.58) 0.44 (0.92) 0.8852

22:6(3) DHA 0.76 (3.01) 1.45 (2.09) 0.3648

Omega 3's combined 1.51 (2.88) 1.94 (1.74) 0.4916

Sat. fatty acids -1.74 (2.28) -4.66 (14.5) 0.6256

Al Pater, PhD; email: old542000@...

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