White blood cell and Korean longevity

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White blood cell and Korean longevity

Hi All,

CRers tend to have lower serum white blood cell levels. How are the levels of

white

blood cells related to longevity and death due to disease? The pdf-available

below

paper, for which only the results of the data for Korean men is provided,

suggests

that it is important and more important in healthy nonsmokers for their white

blood

cells to be low.

Jee SH, Park JY, Kim HS, Lee TY, Samet JM.

White Blood Cell Count and Risk for All-Cause, Cardiovascular, and Cancer

Mortality

in a Cohort of Koreans.

Am J Epidemiol. 2005 Oct 12; [Epub ahead of print]

PMID: 16221804

.... TABLE 3. Hazard ratios* (95% confidence intervals) of white blood cell count

for

death from all causes, all cancers, and all atherosclerotic cardiovascular

diseases

in Korean men, 1993–2003

------------------------------------------------------------------White blood

cell

count, x 10^9 cells/liter

------------------------------------------------------------------ <5.0 5.0–5.9

6.0–6.9 7.0–7.9 8.0–8.9 9.0

------------------------------------------------------------------All deaths

(no. of

cases)

All smokers (n = 22,033) 1.0 0.94 (0.89, 1.00) 0.95 (0.90, 1.00) 0.99 (0.93,

1.05) 1.01 (0.95, 1.07) 1.14 (1.07, 1.21)

Healthy smokers (n = 18,169) 1.0 0.96 (0.89, 1.02) 0.95 (0.89, 1.01) 1.00

(0.94,

1.07) 1.01 (0.95, 1.09) 1.15 (1.08, 1.23)

All nonsmokers (n = 4,488) 1.0 0.96 (0.86, 1.07) 0.97 (0.87, 1.08) 1.05

(0.94,

1.18) 1.20 (1.06, 1.36) 1.38 (1.22, 1.56)

Healthy nonsmokers (n = 3,877) 1.0 1.00 (0.88, 1.13) 1.01 (0.90, 1.14) 1.10

(0.97, 1.24) 1.27 (1.12, 1.46) 1.40 (1.22, 1.60)

All cancers (no. of cases)

All smokers (n = 8,112) 1.0 0.90 (0.82, 0.99) 0.87 (0.80, 0.96) 0.88 (0.80,

0.97) 0.89 (0.80, 0.98) 1.00 (0.90, 1.09)

Healthy smokers (n = 6,787) 1.0 0.91 (0.82, 1.01) 0.86 (0.78, 0.96) 0.92

(0.83,

1.01) 0.89 (0.80, 1.00) 1.00 (0.90, 1.11)

All nonsmokers (n = 1,280) 1.0 0.80 (0.65, 0.97) 0.78 (0.65, 0.95) 0.81

(0.67,

0.99) 0.97 (0.78, 1.20) 0.92 (0.74, 1.16)

Healthy nonsmokers (n = 1,136) 1.0 0.86 (0.70, 1.07) 0.86 (0.70, 1.06) 0.86

(0.69, 1.06) 1.06 (0.84, 1.33) 0.94 (0.73, 1.20)

All atherosclerotic cardiovascular diseases (no. of cases)

All smokers (n = 4,301) 1.0 1.13 (0.97, 1.31) 1.20 (1.04, 1.38) 1.27 (1.10,

1.46) 1.35 (1.16, 1.57) 1.44 (1.25, 1.67)

Healthy smokers (n = 3,571) 1.0 1.11 (0.94, 1.30) 1.19 (1.02, 1.39) 1.24

(1.06,

1.45) 1.30 (1.10, 1.53) 1.46 (1.25, 1.72)

All nonsmokers (n = 983) 1.0 1.48 (1.10, 2.00) 1.76 (1.32, 2.35) 1.99 (1.49,

2.66) 2.26 (1.67, 3.07) 2.33 (1.71, 3.17)

Healthy nonsmokers (n = 831) 1.0 1.38 (1.01, 1.90) 1.65 (1.22, 2.25) 1.84

(1.35,

2.51) 2.14 (1.54, 2.97) 2.10 (1.50, 2.94)

------------------------------------------------------------------* Adjusted for

age, age2, obesity, hypercholesterolemia, hypertension, diabetes, alcohol

drinking,

exercise, and amount of smoking for smokers only.

Al Pater, PhD; email: old542000@...

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