Non-Hodgkin's lymphoma, height, weight

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Hi All,

See the pdf-available paper described partially below suggesting that how tall

we

are and how much we weigh may be related to our acquisition probability for

lymphomas.

Willett EV, Skibola CF, on P, Skibola DR, GJ, MT, Roman E.

Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms.

Br J Cancer. 2005 Sep 13; [Epub ahead of print]

PMID: 16160698

A population-based case-control study of lymphomas in England collected height

and

weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls.

Obesity, defined as a body mass index (BMI) over 30 kg m(-2) at five years

before

diagnosis, was associated with an increased risk of NHL (OR=1.5, 95% CI

1.1-2.1).

The excess was most pronounced for diffuse large B-cell lymphoma (OR=1.9, 95% CI

1.3-2.8). Genetic variants in the leptin (LEP 19G>A, LEP -2548G>A) and leptin

receptor genes (LEPR 223Q>R), previously shown to modulate NHL risk, as well as

a

polymorphism in the energy regulatory gene adiponectin (APM1 276G>T), were

investigated. Findings varied with leptin genotype, the risks being decreased

with

LEP 19AA (OR=0.7, 95% CI 0.5-1.0) and increased with LEP -2548GA (OR=1.3, 95% CI

1.0-1.7) and -2548AA (OR=1.4, 95% CI 1.0-1.9), particularly for follicular

lymphoma.

These genetic findings, which were independent of BMI, were stronger for men

than

women.

.... Table 2 Number of cases and controls, adjusted odds ratios and 95%

confidence

intervals for height

=====================

----NHL b DLBCL b FL b Height a

Control----Case OR c 95% CI Case OR c 95% CI Case OR c 95% CI

========================

Males 495 361 167 103

p1.65 26 19 1.0 0.5–1.9 11 1.4 0.7–3.0 4 0.7 0.2–2.1

1.66–1.73 139 103 1.0 0.7–1.4 45 1.1 0.7–1.7 32 1.0 0.6–1.7

1.74–1.80 214 151 1 — 63 1 — 47 1 —

1.81–1.88 104 82 1.1 0.8–1.6 45 1.5 0.9–2.3 19 0.8 0.5–1.5

41.88 12 6 0.7 0.3–1.9 3 0.8 0.2–3.1 1 0.4 0.0–3.0

Females 419 338 150 125

p1.52 43 35 2.2 0.9–5.1 10 2.9 0.9–9.0 19 1.1 0.4–3.5

1.53–1.57 82 74 1.1 0.6–1.9 28 1.5 0.6–3.3 34 0.9 0.5–1.8

1.58–1.68 226 171 1 — 86 1 — 55 1 —

1.69–1.73 56 38 1.0 0.6–1.6 18 1.6 0.8–3.4 11 0.5 0.3–1.0

41.73 12 20 0.9 0.5–1.6 8 1.4 0.6–3.4 6 0.4 0.2–1.0

======================

a Height, in metres, at diagnosis/reference date.

b NHL = non-Hodgkin’s lymphoma; DLBCL = diffuse large B-cell lymphoma; FL =

follicular lymphoma.

c Odds ratios adjusted for age and region estimated using unconditional logistic

regression.

Table 3 Number of cases and controls, adjusted odds ratios and 95% confidence

intervals by age for body mass index

====================

----NHLb DLBCLb FLb BMIa

Control Case----ORc 95% CI Case ORc 95% CI Case ORc 95% CI

====================

Total 914 699 317 228

Underweight 14 5 0.5 0.2–1.5 2 0.5 0.1–2.0 0 0

Normal 510 347 1 — 159 1 — 120 1 —

Grade 1 298 247 1.2 1.0–1.5 99 1.1 0.8–1.4 80 1.2 0.9–1.6

Grades 2 and 3 89 96 1.5 1.1–2.1 54 1.9 1.3–2.8 27 1.2 0.8–2.0

o45 years 202 107 60 29

Underweight 4 1 0.5 0.1–5.0 1 1.1 0.1–11.0 0

Normal 133 60 1 — 32 1 — 18 1 —

Grade 1 51 26 1.2 0.6–2.1 15 1.2 0.6–2.4 6 1.1 0.4–3.1

Grades 2 and 3 14 17 2.7 1.2–5.8 10 3.0 1.2–7.5 4 1.8 0.5–6.3

45 to o55 years 297 243 107 93

Underweight 8 1 0.2 0.0–1.3 0 0

Normal 174 127 1 — 58 1 — 49 1 —

Grade 1 91 83 1.4 0.9–2.0 32 1.1 0.7–1.9 31 1.3 0.7–2.1

Grades 2 and 3 24 31 1.8 1.0–3.3 16 2.0 1.0–4.1 13 1.9 0.9–4.0

55 to o65 years 415 349 150 106

Underweight 2 3 1.9 0.3–11.3 1 1.5 0.1–16.6 0

Normal 203 160 1 — 69 1 — 53 1 —

Grade 1 156 138 1.1 0.8–1.6 52 1.0 0.6–1.5 43 1.2 0.7–1.8

Grades 2 and 3 51 48 1.2 0.8–1.9 28 1.6 1.0–2.8 10 0.8 0.4–1.6

========================

a Body mass index (BMI) at 5 years prior to diagnosis/reference date where BMI

categorised as underweight: o18.5; normal: 18.5–24.99; grade 1 overweight:

25–29.99;

grades 2 and 3 overweight: =/>30 (WHO Expert Committee on Physical Status,

1995).

BMI was missing for four cases and three controls as weight was not reported.

b NHL = non-Hodgkin’s lymphoma; DLBCL = diffuse large B-cell lymphoma; FL =

follicular lymphoma.

c Odds ratios adjusted for age, sex and region estimated using unconditional

logistic regression. ...

Al Pater, PhD; email: old542000@...

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