Guest guest Posted November 30, 2005 Report Share Posted November 30, 2005 Hi All, A not in Medline yet pdf-available paper describes how best to bioavail ourselves of the goodies in flaxseeds. Anneleen Kuijsten, Ilja C. W. Arts, Pieter van’t Veer, and C. H. Hollman The Relative Bioavailability of Enterolignans in Humans Is Enhanced by Milling and Crushing of Flaxseed J. Nutr. 2005 135: 2812-2816. ABSTRACT Flaxseed is one of the richest sources of lignans and is increasingly used in food products or as a supplement. Plant lignans can be converted by intestinal bacteria into the so-called enterolignans, enterodiol and enterolactone. For a proper evaluation of potential health effects of enterolignans, information on their bioavailability is essential. The aim of this study was to investigate whether crushing and milling of flaxseed enhances the bioavailability of enterolignans in plasma. In a randomized, crossover study, 12 healthy subjects supplemented their diet with 0.3 g whole, crushed, or ground flaxseed/(kg body weight · d). Each subject consumed flaxseed for 10 successive days separated by 11-d run-in/wash-out periods, in which the subjects consumed a diet poor in lignans. Blood samples were collected at the end of each run-in/wash-out period, and at the end of each supplement period. Plasma enterodiol and enterolactone were measured using LC-MS-MS. The mean relative bioavailability of enterolignans from whole compared with ground flaxseed was 28% (P 0.01), whereas that of crushed compared with ground flaxseed was 43% (P 0.01). Crushing and milling of flaxseed substantially improve the bioavailability of the enterolignans. .... Whole and crushed flaxseeds were prepared from the same batch and were provided by a commercial retailer (Weller-Verhoef). To obtain ground flaxseed, we milled part of the whole flaxseed to a coarse texture using a household blender (Waring) for 10 s 4 times and homogenized the particles. ... Al Pater, PhD; email: old542000@... __________________________________ - PC Magazine Editors' Choice 2005 http://mail. Quote Link to comment Share on other sites More sharing options...
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