capsaicin and inflammation

[Guest guest]

There is a new book on Amazon called The Inflammation Nation

by Ed Wendlocher and Kreiss that implicates capsaicin

in inflammatory conditions! I always thought the hot stuff

was good for inflammation. The book description even goes so

far as to call it a " toxin. " Well, maybe it is to some animals,

but humans?!

http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?

v=glance & n=283155 & n=507846 & s=books & v=glance

Any thoughts?

Thanks, -

[Guest guest]

Thanks for the post.

If you've read the book what is the definition of inflammation? Pain related or like atherosclerosis type inflammation that plugs arteries but you might not feel it?

the other book:

http://www.amazon.com/gp/reader/0743269640/ref=sib_rdr_toc/103-5671271-8439043?%5Fencoding=UTF8 & p=S00D & j=0#reader-page

Looks like it's IBD to obesity.

Can't believe it's just capsaicin.

There are things that bother me a lot more than red chili peppers, eg, cilantro, celery, onions, wheat.

If capsaicin is the culprit, then I wonder how many eat it? That many to make an epidemic?

Regards.

[ ] capsaicin and inflammation

There is a new book on Amazon called The Inflammation Nationby Ed Wendlocher and Kreiss that implicates capsaicinin inflammatory conditions! I always thought the hot stuffwas good for inflammation. The book description even goes sofar as to call it a "toxin." Well, maybe it is to some animals,but humans?!http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?v=glance & n=283155 & n=507846 & s=books & v=glanceAny thoughts?Thanks, -

[Guest guest]

Thanks for the post.

If you've read the book what is the definition of inflammation? Pain related or like atherosclerosis type inflammation that plugs arteries but you might not feel it?

the other book:

http://www.amazon.com/gp/reader/0743269640/ref=sib_rdr_toc/103-5671271-8439043?%5Fencoding=UTF8 & p=S00D & j=0#reader-page

Looks like it's IBD to obesity.

Can't believe it's just capsaicin.

There are things that bother me a lot more than red chili peppers, eg, cilantro, celery, onions, wheat.

If capsaicin is the culprit, then I wonder how many eat it? That many to make an epidemic?

Regards.

[ ] capsaicin and inflammation

There is a new book on Amazon called The Inflammation Nationby Ed Wendlocher and Kreiss that implicates capsaicinin inflammatory conditions! I always thought the hot stuffwas good for inflammation. The book description even goes sofar as to call it a "toxin." Well, maybe it is to some animals,but humans?!http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?v=glance & n=283155 & n=507846 & s=books & v=glanceAny thoughts?Thanks, -

[Guest guest]

I have read neither of the books below. However, I did read

Stop Inflammation Now by M. Fleming. He argued the

types of inflammation you segregate in your question are one

and the same.

Personally, I consume a ton of capsaicin; only my morning

smoothie is not hot. So, this is an important topic to me.

Though quitting my pepper habit would be brutal. Am I

really prepared to face what I find and moderate my intake?

I have been pointed to various PubMed articles on another

group, so I may post some, if people are interested.

Regarding his characterization of capsaicin as a toxin, there

are also some studies pointing to its ability to put stress

on the liver, including increased stomach and liver cancers.

Some of these are pretty old, and as with any foodstuff,

there are also papers on its benefits, including anti-cancer

properties (in contradiction to what I just mentioned). So,

it is as confusing as the great coffee, fat, chocolate, etc.

debates.

-

>

> Thanks for the post.

> If you've read the book what is the definition of inflammation? Pain related

or

like atherosclerosis type inflammation that plugs arteries but you might not

feel

it?

>

> the other book:

> http://www.amazon.com/gp/reader/0743269640/ref=sib_rdr_toc/103-5671271

-8439043?%5Fencoding=UTF8 & p=S00D & j=0#reader-page

> Looks like it's IBD to obesity.

>

> Can't believe it's just capsaicin.

> There are things that bother me a lot more than red chili peppers, eg,

cilantro, celery, onions, wheat.

> If capsaicin is the culprit, then I wonder how many eat it? That many to make

an epidemic?

>

> Regards.

>

> [ ] capsaicin and inflammation

>

>

> There is a new book on Amazon called The Inflammation Nation

> by Ed Wendlocher and Kreiss that implicates capsaicin

> in inflammatory conditions! I always thought the hot stuff

> was good for inflammation. The book description even goes so

> far as to call it a " toxin. " Well, maybe it is to some animals,

> but humans?!

>

> http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?

> v=glance & n=283155 & n=507846 & s=books & v=glance

>

>

> Any thoughts?

> Thanks, -

[Guest guest]

I have read neither of the books below. However, I did read

Stop Inflammation Now by M. Fleming. He argued the

types of inflammation you segregate in your question are one

and the same.

Personally, I consume a ton of capsaicin; only my morning

smoothie is not hot. So, this is an important topic to me.

Though quitting my pepper habit would be brutal. Am I

really prepared to face what I find and moderate my intake?

I have been pointed to various PubMed articles on another

group, so I may post some, if people are interested.

Regarding his characterization of capsaicin as a toxin, there

are also some studies pointing to its ability to put stress

on the liver, including increased stomach and liver cancers.

Some of these are pretty old, and as with any foodstuff,

there are also papers on its benefits, including anti-cancer

properties (in contradiction to what I just mentioned). So,

it is as confusing as the great coffee, fat, chocolate, etc.

debates.

-

>

> Thanks for the post.

> If you've read the book what is the definition of inflammation? Pain related

or

like atherosclerosis type inflammation that plugs arteries but you might not

feel

it?

>

> the other book:

> http://www.amazon.com/gp/reader/0743269640/ref=sib_rdr_toc/103-5671271

-8439043?%5Fencoding=UTF8 & p=S00D & j=0#reader-page

> Looks like it's IBD to obesity.

>

> Can't believe it's just capsaicin.

> There are things that bother me a lot more than red chili peppers, eg,

cilantro, celery, onions, wheat.

> If capsaicin is the culprit, then I wonder how many eat it? That many to make

an epidemic?

>

> Regards.

>

> [ ] capsaicin and inflammation

>

>

> There is a new book on Amazon called The Inflammation Nation

> by Ed Wendlocher and Kreiss that implicates capsaicin

> in inflammatory conditions! I always thought the hot stuff

> was good for inflammation. The book description even goes so

> far as to call it a " toxin. " Well, maybe it is to some animals,

> but humans?!

>

> http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?

> v=glance & n=283155 & n=507846 & s=books & v=glance

>

>

> Any thoughts?

> Thanks, -

[Guest guest]

Whenever I hear that one is consuming a " ton " of one particular spice, herb, food (with the exception of leafy greens, perhaps), I cringe. Moderation is the watchword. And the fact that there may be some toxins in the capsaican is a perfect example of why one should be moderate.

Moderation, moderation, moderation.

And food variety as well.

on 11/27/2005 1:12 PM, cronzen at truepatriot@... wrote:

Personally, I consume a ton of capsaicin; only my morning

smoothie is not hot. So, this is an important topic to me.

Though quitting my pepper habit would be brutal. Am I

really prepared to face what I find and moderate my intake?

[Guest guest]

Whenever I hear that one is consuming a " ton " of one particular spice, herb, food (with the exception of leafy greens, perhaps), I cringe. Moderation is the watchword. And the fact that there may be some toxins in the capsaican is a perfect example of why one should be moderate.

Moderation, moderation, moderation.

And food variety as well.

on 11/27/2005 1:12 PM, cronzen at truepatriot@... wrote:

Personally, I consume a ton of capsaicin; only my morning

smoothie is not hot. So, this is an important topic to me.

Though quitting my pepper habit would be brutal. Am I

really prepared to face what I find and moderate my intake?

[Guest guest]

Garlic is a toxin in the sense the liver must remove the components, (as I recall using glutathione). That doesn't make it undesirable to eat, since the chems, IMO, may have a beneficial effect on things like cancer.

ly, I've looked at many chems and for the most part they seem to be centered in things we already eat - tomatoes, carrots, garlic, onions, peppers, basil - many such things.

Per dukes database there are thousands of useful chemicals, if I am to believe the refs.

I found my post on 6/10/04 - detoxification.

From Pizzorno: Textbook of Natural Medicine, 2nd ed.,

Chapter 50 - Detoxification

So the question is what does capsaicin do? Below in Table 50-6, capsaicin is listed as an inhibitor of Phase I detox. So conceivably, capsaicin would inhibit the body's ability to detox inflammatory chemicals.

TABLE 50-3 -- Chemicals detoxified by phase I

Drugs

• Phenytoin

• Erythromycin

• Codeine

• Warfarin

• Amitryptyline

• Phenobarbital

• Prednisone

• Steroids

OTCs

• Acetaminophen

• Ibuprofen

• Salicylates

Foods

• Caffeine

• Vanillin

Nutrients

• Arachidonic acid

• Fatty acids

Environmentals

• Alcohol

• Insecticides

• CCl4

• Benzopyrenes (cigarette smoke, charcoal-broiled meat)

TABLE 50-6 -- Inhibitors of phase I detoxification

Drugs

• Benzodiazepines (e.g. Halcion, Centrax, Librium, Valium, etc.)

• Antihistamines (used for allergies)

• Cimetidine and other stomach-acid secretion blocking drugs (used for stomach ulcers)

• Ketoconazole

• Sulfaphenazole

Foods

• Naringenin from grapefruit juice

• Curcumin from the spice turmeric

• Capsaicin from red chili pepper

• Eugenol from clove oil

• Quercetin from onions

Botanicals

• Curcuma longa (curcumin)

• Capsicum frutescens (capsaicin)

• Eugenia caryophyllus (eugenol)

• Calendula officinalis

Other

• Aging

• Toxins from inappropriate bacteria in the intestines

Phase I detoxification

The liver’s third role in detoxification typically involves a two-step enzymatic process for the neutralization of unwanted chemical compounds ( Table 50.3 ). These not only include drugs, pesticides, and toxins from the gut, but also normal body chemicals such as hormones and inflammatory chemicals (e.g. histamine) which become toxic if allowed to build up. Phase I enzymes directly neutralize some chemicals, but most are converted to intermediate forms that are then processed by phase II enzymes. These intermediate forms are much more chemically active and therefore more toxic. If the phase II detoxification systems are not working adequately, these intermediates can cause substantial damage, including the initiation of carcinogenic processes.

Phase I detoxification of most chemical toxins involves a group of enzymes which, collectively, have been named cytochrome P450. Some 50–100 enzymes make up the cytochrome P450 system. Each enzyme works best in detoxifying certain types of chemicals, but with considerable overlap in activity among the enzymes.

Regards.

[ ] capsaicin and inflammation> > > There is a new book on Amazon called The Inflammation Nation> by Ed Wendlocher and Kreiss that implicates capsaicin> in inflammatory conditions! I always thought the hot stuff> was good for inflammation. The book description even goes so> far as to call it a "toxin." Well, maybe it is to some animals,> but humans?!> > http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?> v=glance & n=283155 & n=507846 & s=books & v=glance> > > Any thoughts?> Thanks, -

[Guest guest]

Garlic is a toxin in the sense the liver must remove the components, (as I recall using glutathione). That doesn't make it undesirable to eat, since the chems, IMO, may have a beneficial effect on things like cancer.

ly, I've looked at many chems and for the most part they seem to be centered in things we already eat - tomatoes, carrots, garlic, onions, peppers, basil - many such things.

Per dukes database there are thousands of useful chemicals, if I am to believe the refs.

I found my post on 6/10/04 - detoxification.

From Pizzorno: Textbook of Natural Medicine, 2nd ed.,

Chapter 50 - Detoxification

So the question is what does capsaicin do? Below in Table 50-6, capsaicin is listed as an inhibitor of Phase I detox. So conceivably, capsaicin would inhibit the body's ability to detox inflammatory chemicals.

TABLE 50-3 -- Chemicals detoxified by phase I

Drugs

• Phenytoin

• Erythromycin

• Codeine

• Warfarin

• Amitryptyline

• Phenobarbital

• Prednisone

• Steroids

OTCs

• Acetaminophen

• Ibuprofen

• Salicylates

Foods

• Caffeine

• Vanillin

Nutrients

• Arachidonic acid

• Fatty acids

Environmentals

• Alcohol

• Insecticides

• CCl4

• Benzopyrenes (cigarette smoke, charcoal-broiled meat)

TABLE 50-6 -- Inhibitors of phase I detoxification

Drugs

• Benzodiazepines (e.g. Halcion, Centrax, Librium, Valium, etc.)

• Antihistamines (used for allergies)

• Cimetidine and other stomach-acid secretion blocking drugs (used for stomach ulcers)

• Ketoconazole

• Sulfaphenazole

Foods

• Naringenin from grapefruit juice

• Curcumin from the spice turmeric

• Capsaicin from red chili pepper

• Eugenol from clove oil

• Quercetin from onions

Botanicals

• Curcuma longa (curcumin)

• Capsicum frutescens (capsaicin)

• Eugenia caryophyllus (eugenol)

• Calendula officinalis

Other

• Aging

• Toxins from inappropriate bacteria in the intestines

Phase I detoxification

The liver’s third role in detoxification typically involves a two-step enzymatic process for the neutralization of unwanted chemical compounds ( Table 50.3 ). These not only include drugs, pesticides, and toxins from the gut, but also normal body chemicals such as hormones and inflammatory chemicals (e.g. histamine) which become toxic if allowed to build up. Phase I enzymes directly neutralize some chemicals, but most are converted to intermediate forms that are then processed by phase II enzymes. These intermediate forms are much more chemically active and therefore more toxic. If the phase II detoxification systems are not working adequately, these intermediates can cause substantial damage, including the initiation of carcinogenic processes.

Phase I detoxification of most chemical toxins involves a group of enzymes which, collectively, have been named cytochrome P450. Some 50–100 enzymes make up the cytochrome P450 system. Each enzyme works best in detoxifying certain types of chemicals, but with considerable overlap in activity among the enzymes.

Regards.

[ ] capsaicin and inflammation> > > There is a new book on Amazon called The Inflammation Nation> by Ed Wendlocher and Kreiss that implicates capsaicin> in inflammatory conditions! I always thought the hot stuff> was good for inflammation. The book description even goes so> far as to call it a "toxin." Well, maybe it is to some animals,> but humans?!> > http://www.amazon.com/gp/product/097588350X/103-8335585-4091068?> v=glance & n=283155 & n=507846 & s=books & v=glance> > > Any thoughts?> Thanks, -

[Guest guest]

I know, I know. Reckon I might be addicted.

-

>

> Personally, I consume a ton of capsaicin; only my morning

> smoothie is not hot. So, this is an important topic to me.

> Though quitting my pepper habit would be brutal. Am I

> really prepared to face what I find and moderate my intake?

>

[Guest guest]

I know, I know. Reckon I might be addicted.

-

>

> Personally, I consume a ton of capsaicin; only my morning

> smoothie is not hot. So, this is an important topic to me.

> Though quitting my pepper habit would be brutal. Am I

> really prepared to face what I find and moderate my intake?

>

[Guest guest]

Here are the PMIDs supplied by the person mentioned below.

I haven't had the chance to weed them all out yet, but rather

than have you all wait on me, I'll just give you the #'s as

they were given to me (though I ordered them). Please feel

free to post the abstracts of any particularly relevant ones.

12721390

12208187

9482766

8769287

7746093

6847703

6380397

3770997

And this site on HIV/AIDS lists cayenne as a liver toxin:

http://www.projinf.org/fs/liver.html

Thanks,

-

>

<snip>

> I have been pointed to various PubMed articles on another

> group, so I may post some, if people are interested.

<snip>

[Guest guest]

Here are the PMIDs supplied by the person mentioned below.

I haven't had the chance to weed them all out yet, but rather

than have you all wait on me, I'll just give you the #'s as

they were given to me (though I ordered them). Please feel

free to post the abstracts of any particularly relevant ones.

12721390

12208187

9482766

8769287

7746093

6847703

6380397

3770997

And this site on HIV/AIDS lists cayenne as a liver toxin:

http://www.projinf.org/fs/liver.html

Thanks,

-

>

<snip>

> I have been pointed to various PubMed articles on another

> group, so I may post some, if people are interested.

<snip>

[Guest guest]

It doesn't look all that good for capsaicin, does it?

If you like chilies, you don't have to eat so much of the capsaicin, you know. Split the dried peppers, remove the seeds and the obvious lining and stew the skins. I also remove the skins after the red has come off - or scrape them. The skins are irritating.

So my chili will be plenty flavorful but not so hot.

Regards.

[ ] Re: capsaicin and inflammation

Here are the PMIDs supplied by the person mentioned below.I haven't had the chance to weed them all out yet, but ratherthan have you all wait on me, I'll just give you the #'s asthey were given to me (though I ordered them). Please feelfree to post the abstracts of any particularly relevant ones.1272139012208187948276687692877746093684770363803973770997And this site on HIV/AIDS lists cayenne as a liver toxin:http://www.projinf.org/fs/liver.htmlThanks,-

[Guest guest]

It doesn't look all that good for capsaicin, does it?

If you like chilies, you don't have to eat so much of the capsaicin, you know. Split the dried peppers, remove the seeds and the obvious lining and stew the skins. I also remove the skins after the red has come off - or scrape them. The skins are irritating.

So my chili will be plenty flavorful but not so hot.

Regards.

[ ] Re: capsaicin and inflammation

Here are the PMIDs supplied by the person mentioned below.I haven't had the chance to weed them all out yet, but ratherthan have you all wait on me, I'll just give you the #'s asthey were given to me (though I ordered them). Please feelfree to post the abstracts of any particularly relevant ones.1272139012208187948276687692877746093684770363803973770997And this site on HIV/AIDS lists cayenne as a liver toxin:http://www.projinf.org/fs/liver.htmlThanks,-

[Guest guest]

perhaps a good ref:

http://www.chemistry.org/portal/a/c/s/1/feature_pro.html?id=939c46f45ade11d7e3d26ed9fe800100

regards.

[ ] Re: capsaicin and inflammation

Here are the PMIDs supplied by the person mentioned below.I haven't had the chance to weed them all out yet, but ratherthan have you all wait on me, I'll just give you the #'s asthey were given to me (though I ordered them). Please feelfree to post the abstracts of any particularly relevant ones.1272139012208187948276687692877746093684770363803973770997And this site on HIV/AIDS lists cayenne as a liver toxin:http://www.projinf.org/fs/liver.htmlThanks,-

[Guest guest]

perhaps a good ref:

http://www.chemistry.org/portal/a/c/s/1/feature_pro.html?id=939c46f45ade11d7e3d26ed9fe800100

regards.

[ ] Re: capsaicin and inflammation

Here are the PMIDs supplied by the person mentioned below.I haven't had the chance to weed them all out yet, but ratherthan have you all wait on me, I'll just give you the #'s asthey were given to me (though I ordered them). Please feelfree to post the abstracts of any particularly relevant ones.1272139012208187948276687692877746093684770363803973770997And this site on HIV/AIDS lists cayenne as a liver toxin:http://www.projinf.org/fs/liver.htmlThanks,-