Carbohydrate restriction regulates the adaptive response to fasting

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Hmmm....

" These results demonstrate that restriction of dietary carbohydrate,

not the general absence of energy intake itself, is responsible for

initiating the metabolic response to short-term fasting. "

I don't know what to make of this but sounds interesting

Can we get full text?

Am J Physiol. 1992 May;262(5 Pt 1):E631-6.

Carbohydrate restriction regulates the adaptive response to fasting.

Klein S, Wolfe RR.

Department of Internal Medicine, University of Texas Medical

Branch, Galveston.

The importance of either carbohydrate or energy restriction in

initiating the metabolic response to fasting was studied in five

normal volunteers. The subjects participated in two study protocols in

a randomized crossover fashion. In one study the subjects fasted for

84 h (control study), and in the other a lipid emulsion was infused

daily to meet resting energy requirements during the 84-h oral fast

(lipid study). Glycerol and palmitic acid rates of appearance in

plasma were determined by infusing [2H5]glycerol and [1-13C]palmitic

acid, respectively, after 12 and 84 h of oral fasting. Changes in

plasma glucose, free fatty acids, ketone bodies, insulin, and

epinephrine concentrations during fasting were the same in both the

control and lipid studies. Glycerol and palmitic acid rates of

appearance increased by 1.63 +/- 0.42 and 1.41 +/- 0.46

mumol.kg-1.min-1, respectively, during fasting in the control study

and by 1.35 +/- 0.41 and 1.43 +/- 0.44 mumol.kg-1.min-1, respectively,

in the lipid study. These results demonstrate that restriction of

dietary carbohydrate, not the general absence of energy intake itself,

is responsible for initiating the metabolic response to short-term

fasting.

PMID: 1590373