Copper benefits health

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Hi All,

Copper apparently benefits health. That an apparently normal level of copper

was in

the basal diet should be important.

See the pdf-available below paper excerpts.

Galhardi CM, Diniz YS, Rodrigues HG, Faine LA, Burneiko RC, Ribas BO, Novelli

EL.

Beneficial effects of dietary copper supplementation on serum lipids and

antioxidant

defenses in rats.

Ann Nutr Metab. 2005 Sep-Oct;49(5):283-8. Epub 2005 Aug 2.

PMID: 16088091

BACKGROUND: A nutrition experiment was utilized to investigate the effects of

two

levels of dietary copper (Cu) supplementation on lipid profile and antioxidant

defenses in serum of rats.

METHODS: Male Wistar rats (180-200 g; n = 10) were divided into three groups:

control group (A), fed a basal diet with 6 microg Cu/g, and rats fed a basal

diet

with Cu (CuSO4) supplementation from aqueous solutions, for 4 weeks at the final

concentrations of 2 mg Cu/rat ( and 3 mg Cu/rat ©.

RESULTS: No significant changes were observed in final body weight, body weight

gain, food consumption, total serum protein and high-density lipoprotein. Cu

supplementation reduced the triacylglycerol (TG), total cholesterol and

low-density

lipoprotein (LDL-C). The LDL-C/TG ratio and total antioxidant substances (TAS)

were

higher in ( and © groups than in (A) group. There was a positive correlation

between Cu supplementation and ceruloplasmin levels. The markers of oxidative

stress, lipid hydroperoxide and lipoperoxide were decreased with Cu

supplementation.

No alterations were observed in superoxide dismutase, indicating saturation of

Cu

enzyme site. The glutathione peroxidase activities (GSH-Px) were increased in

both

Cu-supplemented groups. Considering that a copper-selenium interaction can

affect

mineral availability of both elements, the effects of Cu on TAS and GSH-Px

activities were associated with increased selenium disposal.

Conclusions: Dietary Cu supplementation had beneficial effects on lipid profile

by

improving endogenous antioxidant defenses and decreasing the oxidative stress in

vivo.

.... The rats received deionized water and food ad libitum (Purina,

Campinas,SP,Brazil),with 26.5%protein,3.8%fat,40.0%carbo-

hydrate,4.5%crude fiber,3.5%mineral mix,1.0%vitamin mix and

12.55 kJ/g metabolizable energy.The mineral mixture of the Pu-

rina rodent chow contained all trace elements known to be required

for maintenance,growth and reproduction of rats [13 ].The dietary

copper ... content was 6 g Cu/g.

.... Table 1. Effects of dietary Cu

supplementation on body weight,food

consumption and lipid profile in rats

===============

Biochemical determinations Groups A B C

==============

Initial body weight,g 190.3±11.4 191.5±18.1 190.9±19.8

Final body weight,g 355.3±17.3 367.7±15.1 348.0±14.8

Body weight gain,g 165.0±17.7 176.2±19.0 157.2±16.1

Food consumption,g/day 26.3±1.11 28.6±2.15 26.6±2.15

Total protein,g/dl 6.5±0.10 6.8±0.15 6.6±0.15

TG (SI) 0.99±0.06 b 0.72±0.01 a 0.74±0.02 a

Cholesterol (SI) 2.30±0.11 b 1.95±0.11 a 2.01±0.08 a

HDL-C (SI) 0.98±0.06 0.94±0.08 0.92±0.09

LDL-C (SI) 0.86±0.05 b 0.69±0.06 a 0.76±0.04 a

LDL-C/TG 0.86±0.01 a 0.96±0.01 b 1.02±0.02 b

================

Results are the mean 8 SD.

A =Control rats;

B =rats with dietary Cu supplementation of 2 mg;

C =rats with dietary Cu supplementation of 3 mg.

HDL-C =High-density lipoprotein;LDL-C =low-density lipoprotein;TG

=triacylglycerol.

Different letters indicated significant differences,p <0.05.

.... Table 2. Effects of dietary Cu supplementation on lipid-hydroper-

oxide (HP),lipoperoxide (LP),superoxide-dismutase (SOD),glu-

tathione-peroxidase (GSH-Px),ceruloplasmin and total antioxi-

dant substances (TAS)in serum of rats

===============

Biochemical determinations Groups A B C

==============

HP,nmol/ml 4.5±0.1 b 3.4±0.4 a 3.6±0.1 a

LP,nmol/ml 8.4±1.2 b 6.5±0.9 a 6.1±1.1 a

SOD,U/mg protein 3.2±0.01 3.3±0.04 3.2±0.05

GSH-Px,U/mg protein 97.1±3.4 a 117.7±1.3 b 119.3±9.1 b

Ceruloplasmin,U/ml 65.7±5.0 a 86.5±5.0 b 95.2±5.4 c

TAS,%35.3±3.1 a 44.1±2.7 b 46.2±1.9 b

================

Results are the mean 8 SD.

A =Control rats;

B =rats with dietary Cu supplementation of 2 mg;

C =rats with dietary Cu supplementation of 3 mg.

HDL-C =High-density lipoprotein;LDL-C =low-density lipoprotein;TG

=triacylglycerol.

Different letters indicated significant differences,p <0.05.

Al Pater, PhD; email: old542000@...

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