New brain toxin protection by CR

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Hi All,

In the available full-text of:

Contestabile A, Ciani E, Contestabile A.

Dietary restriction differentially protects from neurodegeneration in animal

models

of excitotoxicity.

Brain Res. 2004 Mar 26;1002(1-2):162-6.

PMID: 14988047

In the not pdf-available in press paper below described for its abstract, CR

seems

to alleviate the toxicity of another toxin, a neurotoxin called kainic acid ->

kainate. A tie-in is made with heat shock protein 70 in the neuroprotection

against

kainate toxicity by CR.

For definition and background, see:

kainic acid -->kainate: An agonist for the K type excitatory amino acid

receptor. It

can act as an excitotoxin producing symptoms similar to those of Huntingdon's

chorea

and is also used as an anthelminthic drug. Originally isolated from the alga

Digenea

simplex. The receptor is an amino acid gated ion channel, one of several types

gated

by the transmitter.

" Domoic acid (DA), structurally related to glutamic and kainic acid, mainly

generated by Pseudo nitzschia diatom. It often contaminates halobios such as

fish

and seashell and cause the Amnesic Shellfish Poisoning in human beings with the

consumption of foods contaminated by DA. "

Here, is the abstract.

Neuroprotective potential of dietary restriction against kainate-induced

excitotoxicity in adult male Wistar rats

Brain Research Bulletin, In Press, Uncorrected Proof, Available online 30 August

2005,

Sandeep Sharma and Gurcharan Kaur

Abstract

The influence that dietary factors have on the nervous system and its

susceptibility

to disease, is an active area of biomedical research. Recent studies have shown

that

dietary restriction (DR) can have profound effect on brain function and

vulnerability to injury and disease and can also enhance synaptic plasticity,

which

may increase the ability of brain to resist aging and restore function following

injury. The dietary restriction may result in neuroprotection as suggested by

marked

reduction in neuronal cell death of the CA3 region of hippocampus after kainate

administration in our study. We examined the effects of 3 months of DR

(alternate

day feeding regimen) on the antioxidants and antioxidant enzymes from different

brain regions such as cerebral hemispheres, diencephalon, cerebellum and brain

stem

after kainate-induced excitotoxicity in adult male Wistar rats. The present

study

reports the beneficial effects of dietary restriction on different antioxidants

and

antioxidant enzymes against kainate-induced excitotoxicity in different brain

regions of young adult male Wistar rats. The expression of stress response

protein

heat shock protein 70 (HSP 70) was also studied from discrete regions of rat

brain

under the same set of experimental conditions. DR significantly enhanced the

expression of HSP 70 in kainic acid (KA)-treated rats, whereas KA treatment of

ad

libitum fed rats resulted in decreased HSP 70 expression. The DR was observed to

exert neuroprotection by enhancing the expression of HSP 70 in kainic acid

treated

rats.

Al Pater, PhD; email: old542000@...

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