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Bones, Heart Disease

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Hi folks:

From the latest Dr. Mirkin email newsletter. The second paragraph

especially is interesting, and presumably true (????):

Dear Dr. Mirkin: My doctor says the bone-strengthening medicine

I take is also good for my heart. Is this true?

Almost all treatments for osteoporosis help to prevent

arteriosclerosis also. A study in QJM helps to explain why

(Volume 98, 2005). Statins such as Pravachol, Zocor and Lipitor,

used to lower cholesterol, strengthen bones. Bisphosphonates,

such as Fosamax and Actinal, used to treat weak bones, also

help to lower cholesterol and prevent heart attacks. Drugs such

as Actos and Avandia, used to treat diabetes and lower

triglycerides, also help to strengthen bones.

Osteoporosis occurs when fat cells replace bone cells in

bones. Stem cells in bone marrow can form either bone or fat

cells. We do not know the signal that encourages bone marrow

stem cells to form fat instead of bone, but this recent data show

that factors that help to prevent arteriosclerosis may also help to

prevent osteoporosis. This is one more reason to eat a diet rich

in plants, exercise regularly, and treat osteoporosis and high

cholesterol vigorously.

Rodney.

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