BMI // CRP // TRG

[Guest guest]

Hi folks:

If CRP is important then BMIs < 22 and TRG < 100 are very important,

it seems:

" High prevalence of C-reactive protein elevation with normal

triglycerides (100-149 mg/dL): are triglyceride levels below 100

mg/dL more optimal in coronary heart disease risk assessment?

Ahmad I, Zhan M, M.

School of Public Health, Yale University, New Haven, Connecticut, USA.

BACKGROUND: The National Cholesterol Education Program defines a

fasting triglyceride level below 150 mg/dL as normal. However,

observational data suggest that triglyceride levels above 100 mg/dL

may predict coronary heart disease (CHD) events. METHODS: To

determine the prevalence of systemic inflammation with a normal

triglyceride level (100-149 mg/dL), data obtained from the population-

based cross-sectional study of 4412 men and women in the third

National Health and Nutrition Examination Survey were reviewed.

Measurements included fasting lipids and lipoproteins and serum C-

reactive protein (CRP) level measured using a Behring Nephelometer

Analyzer System. RESULTS: High CRP level was equally prevalent

whether the designated triglyceride cutpoint was greater than or

equal to 100 (unadjusted OR, 2.0; 95% CI, 1.7-2.3) or greater than or

equal to 150 (unadjusted OR, 1.9; 95% CI, 1.6-2.2). After adjustment

for other covariates, the triglyceride range of 100 to 149 mg/dL

remained independently associated with elevated CRP level (OR, 1.3;

95% CI, 1.02-1.67). In addition, an approximately fivefold higher

likelihood of elevated CRP level was observed with triglyceride

levels between 100 and 149 mg/dL and normal body mass index (BMI; 24-

24.9) compared with lower triglyceride level (<65 mg/dL) and BMI

(<22) (P < 0.0001). CONCLUSIONS: These data indicate that " normal "

triglyceride levels (100-150 mg/dL) are associated with systemic

inflammation and that lower fasting triglyceride levels (eg, <100

rather than <150 mg/dL) may be a more optimal cutpoint in CHD risk

assessment. "

PMID: 15832099

Rodney.