Guest guest Posted July 20, 2005 Report Share Posted July 20, 2005 Physician Specialization and Quality of HIV Care Landon BE, IB, McInnes K, et al. Physician specialization and the quality of care for human immunodeficiency virus infection. Arch Intern Med. 2005;165:1133-1139 . The authors studied the association between specialty training and HIV expertise with the care delivered to persons with HIV infection. Methods: The evaluation involved 64 clinics funded by the White Care Act with at least 100 patients. At each clinic, there was a random selection of up to 75 patients to have medical record reviews during 2000 and 2001. Clinicians providing care for these patients were surveyed and linked to the patients whose medical records were reviewed. Patients receiving care from nonphysician providers were excluded. Representative quality indicators were (1) receipt of HAART if the CD4+ cell count was < 500 cells/mcL or if the viral load was > 10,000 copies/mL; (2) achievement of a viral load < 400 copies/mL; (3) Pneumocystis jiroveci pneumonia (previously known as Pneumocystis carinii pneumonia, or PCP) prophylaxis, if indicated; and (4) access to care, defined as visits during at least 3 of 4 quarters. Physicians were identified as specialists if trained in infectious diseases vs general medicine, and generalists were asked whether they considered themselves " experts " in treatment of HIV. Providers were categorized by caseload as low (0-19 patients), medium (20-299 patients), or high (over 300 patients). Results: The results are based on 5247 patients linked to 177 physicians who responded to the survey. Of the 177 respondents, 58% indicated that they were trained in general medicine and 42% were classified as infectious disease specialists. Of the physicians considered " generalists, " 63% considered themselves experts in HIV care. With regard to outcome, there was no difference for the parameters measured indicating quality of HIV care, appropriate screening, or routine care between infectious disease trained physicians and generalists who considered themselves HIV experts. Nonexpert generalists were significantly less likely to have patients appropriately given HAART and less likely to have patients with a viral load < 400 copies/mL when compared with experts. Similarly, all physicians with caseloads smaller than 20 patients were less likely to have patients on HAART when indicated compared with those with higher caseloads. These results are summarized in Table 7 . (Sorry, the table is note presented pleasre refere to the url Moderator. AIDS INDIA e FORUM) The findings support previous studies that showed that quality of care, to a great extent, is correlated with self-reported expertise. Comment: This is one of several reports to indicate that expertise is correlated with outcome in care of HIV-infected patients. Nevertheless, the difference was modest. Most significant was a viral load of < 400 copies/mL, which is rarely sought in these kinds of analyses. For the nonexpert generalists, this was achieved in 31% compared with 39% among patients receiving care from an expert generalists and 41% for ID-trained physicians (P = .01). There was also a significant difference in the number given HAART, but the indications at the time of the study were different; the CD4+ threshold was 500 cells/mcL and the viral load threshold used in the study is not in anyone's guidelines. The study supports previous reports indicating that generalists can develop expertise in HIV infection as previously reported by Stone and coworkers.[14] Of interest is the observation, once again, that panel size correlated with favorable outcome, but those with a heavy patient load did no better than those with a panel size of 20-300 patients. It might be mentioned that the current DHHS guidelines recommend a panel size of at least 25 patients. 1. RP, Kaur A. HIV: viral blitzkrieg. Nature. 2005;434:1080- 1081. 2. Veazey RS, Lackner AA. HIV swiftly guts the immune system. Nat Med. 2005;11:469-470. Abstract 3. Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759. Abstract 4. Mehandru S, Poles MA, Tenner-Racz K, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. 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Tumour necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy. AIDS. 2003;17:121-123. Abstract 21. Raijmakers MT, Jansen PL, Steegers EA, s WH. Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol. 2000;33:348-351. Abstract 22. Zucker SD, Qin X, Rouster SD, et al. Mechanism of indinavir- induced hyperbilirubinemia. Proc Natl Acad Sci U S A. 2001;98:12671- 12676. Abstract 23. Marzolini C, Paus E, Buclin T, Kim RB. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004;75:13-33. Abstract 24. Kim RB, Fromm MF, Wandel C, et al. The drug transporter P- glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998;101:289-294. Abstract http://www.medscape.com/viewarticle/507564_4 Quote Link to comment Share on other sites More sharing options...
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