Acrylamide does not cause colon cancer

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Hi All,

No real surprise for me is the pdf-available below. Acrylamide does not cause

colon

cancer.

Mucci LA, Adami HO, Wolk A.

Prospective study of dietary acrylamide and risk of colorectal cancer among

women.

Int J Cancer. 2005 Jul 7;118(1):169-173 [Epub ahead of print]

PMID: 16003738

There has been considerable discourse about whether exposure to acrylamide in

foods

could increase the risk of human cancer. Acrylamide is classified as a probable

human carcinogen, and animal studies have demonstrated an increased incidence of

tumors in rats exposed to very high levels. Still, epidemiologic data of the

effect

of dietary acrylamide remain scant. We have undertaken the first prospective

study

of acrylamide in food and risk of colon and rectal cancers using prospective

data

from the Swedish Mammography Cohort. The cohort comprised 61,467 women at

baseline

between 1987 and 1990. Through 2003, the cohort contributed 823,072

person-years,

and 504 cases of colon and 237 of rectal cancer occurred. Mean intake of

acrylamide

through diet was 24.6 mug/day (Q25-70 = 18.7-29.9). Coffee (44%), fried potato

products (16%), crisp bread (15%) and other breads (12%) were the greatest

contributors. After adjusting for potential confounders, there was no

association

between estimated acrylamide intake and colorectal cancer. Comparing extreme

quintiles, the adjusted relative risks (95% CI; p for trend) were for colorectal

cancer 0.9 (0.7-1.3; p = 0.80), colon cancer 0.9 (0.6-1.4; p = 0.83) and rectal

cancer 1.0 (0.6-1.8; p = 0.77). Furthermore, intake of specific food items with

elevated acrylamide (e.g., coffee, crisp bread and fried potato products) was

not

associated with cancer risk. In this large prospective study, we found no

evidence

that dietary intake of acrylamide is associated with cancers of the colon or

rectum.

Epidemiologic studies play an important role in assessing the possible health

effects of acrylamide intake through food.

Al Pater, PhD; email: old542000@...

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