High-fat animal diet bad from low-fat plant diet

[Guest guest]

Hi All,

It seems that:

" the antecedent consumption of [a low-fat and plant protein diet] possibly

accelerates and augments the development of glucose dysregulation via decreased

insulin secretion capacity and pancreatic beta-cell mass when the diets switch

to [a

high-fat and animal protein diet]. "

was not the only finding of the not pdf-available below paper.

Park S, Park CH, Jang JS.

Antecedent intake of traditional Asian-style diets exacerbates pancreatic

beta-cell

function, growth and survival after Western-style diet feeding in weaning male

rats.

J Nutr Biochem. 2005 Aug 25; [Epub ahead of print]

PMID: 16223578

The prevalence of type 2 diabetes has been rapidly increasing in conjunction

with

the westernization of diet patterns in Asia. We determined whether the

antecedent

consumption of traditional Asian-style diets (ADs) deteriorates insulin action,

insulin secretion and pancreatic beta-cell mass after subsequent imposition of

the

diabetogenic challenge of Western-style diets (WDs) in weaning male

Sprague-Dawley

rats. Rats were provided AD (a low-fat and plant protein diet), WD (a high-fat

and

animal protein diet) or a control diet (CD) (a low-fat and animal protein diet)

for

12 weeks. After 12 weeks, the groups were divided into two subsets; one set of

the

groups continued to consume their previous diets of WD, AD and CD for another 12

weeks, and the second set was divided into three groups represented by a switch

in

their designated diets from WD to AD, AD to WD and CD to WD. Whole-body glucose

disposal rates and GLUT4 contents in soleus muscles were lower in WD regardless

of

the antecedent protein sources. The first-phase insulin secretion was higher in

the

CD group than in the other groups, whereas the second phase was lowered with AD

consumption as antecedent and/or present diets. Asian-style diet and AD-WD

intake

did not compensate for insulin resistance due to the failure of beta-cell

expansion

via decreased proliferation. These findings suggest that the antecedent

consumption

of AD possibly accelerates and augments the development of glucose dysregulation

via

decreased insulin secretion capacity and pancreatic beta-cell mass when the

diets

switch to WD.

Al Pater, PhD; email: old542000@...

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