Re: Another diet -more personal thoughts

[Guest guest]

[snip]

> But the question always in my mind is that 3 females in mine and my

wife's family all over 80, exhibit this " familial hypercholestero.. " ,

so I sincerely doubt the 1 in 500.

[snip]

=====

JW,

The statistics come from the 1985 Nobel laureate's lecture in

Physiology or Medicine:

Tony

====

http://nobelprize.org/medicine/laureates/1985/press.html

" Studies on patients with familial hypercholesterolemia (FH) by

S. Brown and ph L. Goldstein constitute founding stones

for our present knowledge concerning the cholesterol metabolism. FH

exists in different forms and is inherited as a monogenic dominant

trait. Individuals who carry the mutant gene in double dose

(homozygotes) are severely affected. Their serum cholesterol levels

are five times higher than in healthy persons, and severe

atherosclerosis and coronary infarction is seen already in

adolescence, or even earlier. Individuals who have inherited only one

mutant gene (heterozygotes) develop symptoms later in life - at 35 to

55 years of age. Their cholesterol levels are approximately 2-3 times

higher than in normal people. "

" The severe form of FH (homozygous) is rare, about one in a million

people. The milder form of FH (heterozygous) is much more common,

about one in 200-500 people. This means that in a city like Stockholm

several thousand inhabitants have the disease with its associated

risks of atherosclerosis and heart infarction. "

[Guest guest]

[snip]

> But the question always in my mind is that 3 females in mine and my

wife's family all over 80, exhibit this " familial hypercholestero.. " ,

so I sincerely doubt the 1 in 500.

[snip]

=====

JW,

The statistics come from the 1985 Nobel laureate's lecture in

Physiology or Medicine:

Tony

====

http://nobelprize.org/medicine/laureates/1985/press.html

" Studies on patients with familial hypercholesterolemia (FH) by

S. Brown and ph L. Goldstein constitute founding stones

for our present knowledge concerning the cholesterol metabolism. FH

exists in different forms and is inherited as a monogenic dominant

trait. Individuals who carry the mutant gene in double dose

(homozygotes) are severely affected. Their serum cholesterol levels

are five times higher than in healthy persons, and severe

atherosclerosis and coronary infarction is seen already in

adolescence, or even earlier. Individuals who have inherited only one

mutant gene (heterozygotes) develop symptoms later in life - at 35 to

55 years of age. Their cholesterol levels are approximately 2-3 times

higher than in normal people. "

" The severe form of FH (homozygous) is rare, about one in a million

people. The milder form of FH (heterozygous) is much more common,

about one in 200-500 people. This means that in a city like Stockholm

several thousand inhabitants have the disease with its associated

risks of atherosclerosis and heart infarction. "